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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Role of Influenza A Virus Hemagglutinin Residues 226 and 228 in Receptor Specificity and Host Range Restriction</title><author><name sortKey="Vines, Angela" sort="Vines, Angela" uniqKey="Vines A" first="Angela" last="Vines">Angela Vines</name><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation></author><author><name sortKey="Wells, Krisna" sort="Wells, Krisna" uniqKey="Wells K" first="Krisna" last="Wells">Krisna Wells</name><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation></author><author><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation></author><author><name sortKey="Castrucci, Maria R" sort="Castrucci, Maria R" uniqKey="Castrucci M" first="Maria R." last="Castrucci">Maria R. Castrucci</name><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation></author><author><name sortKey="Ito, Toshihiro" sort="Ito, Toshihiro" uniqKey="Ito T" first="Toshihiro" last="Ito">Toshihiro Ito</name><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">9696865</idno><idno type="pmc">110023</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC110023</idno><idno type="RBID">PMC:110023</idno><date when="1998">1998</date><idno type="wicri:Area/Pmc/Corpus">000145</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000145</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Role of Influenza A Virus Hemagglutinin Residues 226 and 228 in Receptor Specificity and Host Range Restriction</title><author><name sortKey="Vines, Angela" sort="Vines, Angela" uniqKey="Vines A" first="Angela" last="Vines">Angela Vines</name><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation></author><author><name sortKey="Wells, Krisna" sort="Wells, Krisna" uniqKey="Wells K" first="Krisna" last="Wells">Krisna Wells</name><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation></author><author><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation></author><author><name sortKey="Castrucci, Maria R" sort="Castrucci, Maria R" uniqKey="Castrucci M" first="Maria R." last="Castrucci">Maria R. Castrucci</name><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation></author><author><name sortKey="Ito, Toshihiro" sort="Ito, Toshihiro" uniqKey="Ito T" first="Toshihiro" last="Ito">Toshihiro Ito</name><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation><affiliation><nlm:aff id="N0x9c08f78.0x994a080"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="1998">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza A viruses can be isolated from a variety of animals, but their range of hosts is restricted. For example, human influenza viruses do not replicate in duck intestine, the major replication site of avian viruses in ducks. Although amino acids at positions 226 and 228 of hemagglutinin (HA) of the H3 subtype are known to be important for this host range restriction, the contributions of specific amino acids at these positions to restriction were not known. Here, we address this issue by generating HAs with site-specific mutations of a human virus that contain different amino acid residues at these positions. We also let ducks select replication-competent viruses from a replication-incompetent virus containing a human virus HA by inoculating animals with 10<sup>10.5</sup> 50% egg infectious dose of the latter virus and identified a mutation in the HA. Our results showed that the Ser-to-Gly mutation at position 228, in addition to the Leu-to-Gln mutation at position 226 of the HA of the H3 subtype, is critical for human virus HA to support virus replication in duck intestine.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="publisher-id">J VIROL</journal-id><journal-title>Journal of Virology</journal-title><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">9696865</article-id><article-id pub-id-type="pmc">110023</article-id><article-id pub-id-type="publisher-id">0393</article-id><article-categories><subj-group subj-group-type="heading"><subject>Animal Viruses</subject></subj-group><series-title>Note</series-title></article-categories><title-group><article-title>The Role of Influenza A Virus Hemagglutinin Residues 226 and 228 in Receptor Specificity and Host Range Restriction</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Vines</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="N0x9c08f78.0x994a080">1</xref><xref ref-type="author-notes" rid="FN151">†</xref></contrib><contrib contrib-type="author"><name><surname>Wells</surname><given-names>Krisna</given-names></name><xref ref-type="aff" rid="N0x9c08f78.0x994a080">1</xref><xref ref-type="aff" rid="N0x9c08f78.0x994a080">2</xref></contrib><contrib contrib-type="author"><name><surname>Matrosovich</surname><given-names>Mikhail</given-names></name><xref ref-type="aff" rid="N0x9c08f78.0x994a080">1</xref></contrib><contrib contrib-type="author"><name><surname>Castrucci</surname><given-names>Maria R.</given-names></name><xref ref-type="aff" rid="N0x9c08f78.0x994a080">3</xref></contrib><contrib contrib-type="author"><name><surname>Ito</surname><given-names>Toshihiro</given-names></name><xref ref-type="aff" rid="N0x9c08f78.0x994a080">4</xref></contrib><contrib contrib-type="author"><name><surname>Kawaoka</surname><given-names>Yoshihiro</given-names></name><xref ref-type="aff" rid="N0x9c08f78.0x994a080">1</xref><xref ref-type="aff" rid="N0x9c08f78.0x994a080">2</xref><xref ref-type="aff" rid="N0x9c08f78.0x994a080">5</xref><xref ref-type="author-notes" rid="FN150">*</xref></contrib></contrib-group><aff id="N0x9c08f78.0x994a080"> Department of Virology and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105<sup>1</sup>; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin 53706<sup>2</sup>; Department of Virology, Instituto Superiore di Sanita, 00161 Rome, Italy<sup>3</sup>; Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori 680, Japan<sup>4</sup>; and Department of Pathology, University of Tennessee, Memphis, Memphis, Tennessee 38163<sup>5</sup></aff><author-notes><fn id="FN150"><label>*</label><p>Corresponding author. Mailing address: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, 2015 Linden Dr. West, Madison, WI 53706. Phone: (608) 265-4925. Fax: (608) 265-5622. E-mail: <email>kawaokay@svm.vetmed.wisc.edu</email>.</p></fn><fn id="FN151"><label>†</label><p>Present address: Department of Biology, Spelman College, Atlanta, GA 30314-4399.</p></fn></author-notes><pub-date pub-type="ppub"><month>9</month><year>1998</year></pub-date><volume>72</volume><issue>9</issue><fpage>7626</fpage><lpage>7631</lpage><history><date date-type="received"><day>13</day><month>3</month><year>1998</year></date><date date-type="accepted"><day>19</day><month>5</month><year>1998</year></date></history><copyright-statement>Copyright © 1998, American Society for Microbiology</copyright-statement><copyright-year>1998</copyright-year><abstract><p>Influenza A viruses can be isolated from a variety of animals, but their range of hosts is restricted. For example, human influenza viruses do not replicate in duck intestine, the major replication site of avian viruses in ducks. Although amino acids at positions 226 and 228 of hemagglutinin (HA) of the H3 subtype are known to be important for this host range restriction, the contributions of specific amino acids at these positions to restriction were not known. Here, we address this issue by generating HAs with site-specific mutations of a human virus that contain different amino acid residues at these positions. We also let ducks select replication-competent viruses from a replication-incompetent virus containing a human virus HA by inoculating animals with 10<sup>10.5</sup> 50% egg infectious dose of the latter virus and identified a mutation in the HA. Our results showed that the Ser-to-Gly mutation at position 228, in addition to the Leu-to-Gln mutation at position 226 of the HA of the H3 subtype, is critical for human virus HA to support virus replication in duck intestine.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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