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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sialic Acid Species as a Determinant of the Host Range of Influenza A Viruses</title><author><name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Ito, Toshihiro" sort="Ito, Toshihiro" uniqKey="Ito T" first="Toshihiro" last="Ito">Toshihiro Ito</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Suzuki, Takashi" sort="Suzuki, Takashi" uniqKey="Suzuki T" first="Takashi" last="Suzuki">Takashi Suzuki</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Holland, Robert E" sort="Holland, Robert E" uniqKey="Holland R" first="Robert E." last="Holland">Robert E. Holland</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Chambers, Thomas M" sort="Chambers, Thomas M" uniqKey="Chambers T" first="Thomas M." last="Chambers">Thomas M. Chambers</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Kiso, Makoto" sort="Kiso, Makoto" uniqKey="Kiso M" first="Makoto" last="Kiso">Makoto Kiso</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Ishida, Hideharu" sort="Ishida, Hideharu" uniqKey="Ishida H" first="Hideharu" last="Ishida">Hideharu Ishida</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">11090182</idno><idno type="pmc">112465</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC112465</idno><idno type="RBID">PMC:112465</idno><date when="2000">2000</date><idno type="wicri:Area/Pmc/Corpus">000138</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000138</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sialic Acid Species as a Determinant of the Host Range of Influenza A Viruses</title><author><name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Ito, Toshihiro" sort="Ito, Toshihiro" uniqKey="Ito T" first="Toshihiro" last="Ito">Toshihiro Ito</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Suzuki, Takashi" sort="Suzuki, Takashi" uniqKey="Suzuki T" first="Takashi" last="Suzuki">Takashi Suzuki</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Holland, Robert E" sort="Holland, Robert E" uniqKey="Holland R" first="Robert E." last="Holland">Robert E. Holland</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Chambers, Thomas M" sort="Chambers, Thomas M" uniqKey="Chambers T" first="Thomas M." last="Chambers">Thomas M. Chambers</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Kiso, Makoto" sort="Kiso, Makoto" uniqKey="Kiso M" first="Makoto" last="Kiso">Makoto Kiso</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Ishida, Hideharu" sort="Ishida, Hideharu" uniqKey="Ishida H" first="Hideharu" last="Ishida">Hideharu Ishida</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation><affiliation><nlm:aff id="N0x994c4f8.0x98e7ff0"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The distribution of sialic acid (SA) species varies among animal species, but the biological role of this variation is largely unknown. Influenza viruses differ in their ability to recognize SA-galactose (Gal) linkages, depending on the animal hosts from which they are isolated. For example, human viruses preferentially recognize SA linked to Gal by the α2,6(SAα2,6Gal) linkage, while equine viruses favor SAα2,3Gal. However, whether a difference in relative abundance of specific SA species (<italic>N</italic>-acetylneuraminic acid [NeuAc] and <italic>N</italic>-glycolylneuraminic acid [NeuGc]) among different animals affects the replicative potential of influenza viruses is uncertain. We therefore examined the requirement for the hemagglutinin (HA) for support of viral replication in horses, using viruses whose HAs differ in receptor specificity. A virus with an HA recognizing NeuAcα2,6Gal but not NeuAcα2,3Gal or NeuGcα2,3Gal failed to replicate in horses, while one with an HA recognizing the NeuGcα2,3Gal moiety replicated in horses. Furthermore, biochemical and immunohistochemical analyses and a lectin-binding assay demonstrated the abundance of the NeuGcα2,3Gal moiety in epithelial cells of horse trachea, indicating that recognition of this moiety is critical for viral replication in horses. Thus, these results provide evidence of a biological effect of different SA species in different animals.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="publisher-id">J VIROL</journal-id><journal-title>Journal of Virology</journal-title><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">11090182</article-id><article-id pub-id-type="pmc">112465</article-id><article-id pub-id-type="publisher-id">0798</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject></subj-group></article-categories><title-group><article-title>Sialic Acid Species as a Determinant of the Host Range of Influenza A Viruses</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Suzuki</surname><given-names>Yasuo</given-names></name><xref ref-type="aff" rid="N0x994c4f8.0x98e7ff0">1</xref></contrib><contrib contrib-type="author"><name><surname>Ito</surname><given-names>Toshihiro</given-names></name><xref ref-type="aff" rid="N0x994c4f8.0x98e7ff0">2</xref></contrib><contrib contrib-type="author"><name><surname>Suzuki</surname><given-names>Takashi</given-names></name><xref ref-type="aff" rid="N0x994c4f8.0x98e7ff0">1</xref></contrib><contrib contrib-type="author"><name><surname>Holland</surname><given-names>Robert E.</given-names><suffix>Jr.</suffix></name><xref ref-type="aff" rid="N0x994c4f8.0x98e7ff0">3</xref></contrib><contrib contrib-type="author"><name><surname>Chambers</surname><given-names>Thomas M.</given-names></name><xref ref-type="aff" rid="N0x994c4f8.0x98e7ff0">3</xref></contrib><contrib contrib-type="author"><name><surname>Kiso</surname><given-names>Makoto</given-names></name><xref ref-type="aff" rid="N0x994c4f8.0x98e7ff0">4</xref></contrib><contrib contrib-type="author"><name><surname>Ishida</surname><given-names>Hideharu</given-names></name><xref ref-type="aff" rid="N0x994c4f8.0x98e7ff0">4</xref></contrib><contrib contrib-type="author"><name><surname>Kawaoka</surname><given-names>Yoshihiro</given-names></name><xref ref-type="aff" rid="N0x994c4f8.0x98e7ff0">5</xref><xref ref-type="aff" rid="N0x994c4f8.0x98e7ff0">6</xref><xref ref-type="author-notes" rid="FN150">*</xref></contrib></contrib-group><aff id="N0x994c4f8.0x98e7ff0"> Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Shizuoka-shi 422-8526,<sup>1</sup> Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori 680-8553,<sup>2</sup> Department of Applied Bioorganic Chemistry, Gifu University, Gifu 501-1193,<sup>4</sup> and Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,<sup>6</sup> Japan; Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky 40546<sup>3</sup>; and Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53706<sup>5</sup></aff><author-notes><fn id="FN150"><label>*</label><p>Corresponding author. Mailing address: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Dr. West, Madison, WI 53706. Phone: (608) 265-4925. Fax: (608) 265-5622. E-mail: <email>kawaokay@svm.vetmed.wisc.edu</email>.</p></fn></author-notes><pub-date pub-type="ppub"><month>12</month><year>2000</year></pub-date><volume>74</volume><issue>24</issue><fpage>11825</fpage><lpage>11831</lpage><history><date date-type="received"><day>3</day><month>5</month><year>2000</year></date><date date-type="accepted"><day>14</day><month>9</month><year>2000</year></date></history><copyright-statement>Copyright © 2000, American Society for Microbiology</copyright-statement><copyright-year>2000</copyright-year><abstract><p>The distribution of sialic acid (SA) species varies among animal species, but the biological role of this variation is largely unknown. Influenza viruses differ in their ability to recognize SA-galactose (Gal) linkages, depending on the animal hosts from which they are isolated. For example, human viruses preferentially recognize SA linked to Gal by the α2,6(SAα2,6Gal) linkage, while equine viruses favor SAα2,3Gal. However, whether a difference in relative abundance of specific SA species (<italic>N</italic>-acetylneuraminic acid [NeuAc] and <italic>N</italic>-glycolylneuraminic acid [NeuGc]) among different animals affects the replicative potential of influenza viruses is uncertain. We therefore examined the requirement for the hemagglutinin (HA) for support of viral replication in horses, using viruses whose HAs differ in receptor specificity. A virus with an HA recognizing NeuAcα2,6Gal but not NeuAcα2,3Gal or NeuGcα2,3Gal failed to replicate in horses, while one with an HA recognizing the NeuGcα2,3Gal moiety replicated in horses. Furthermore, biochemical and immunohistochemical analyses and a lectin-binding assay demonstrated the abundance of the NeuGcα2,3Gal moiety in epithelial cells of horse trachea, indicating that recognition of this moiety is critical for viral replication in horses. Thus, these results provide evidence of a biological effect of different SA species in different animals.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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