Comparative Analysis of Evolutionary Mechanisms of the Hemagglutinin and Three Internal Protein Genes of Influenza B Virus: Multiple Cocirculating Lineages and Frequent Reassortment of the NP, M, and NS Genes
Identifieur interne : 000133 ( Pmc/Corpus ); précédent : 000132; suivant : 000134Comparative Analysis of Evolutionary Mechanisms of the Hemagglutinin and Three Internal Protein Genes of Influenza B Virus: Multiple Cocirculating Lineages and Frequent Reassortment of the NP, M, and NS Genes
Auteurs : Stephen E. Lindstrom ; Yasuaki Hiromoto ; Hidekazu Nishimura ; Takehiko Saito ; Reiko Nerome ; Kuniaki NeromeSource :
- Journal of Virology [ 0022-538X ] ; 1999.
Abstract
Phylogenetic profiles of the genes coding for the hemagglutinin (HA) protein, nucleoprotein (NP), matrix (M) protein, and nonstructural (NS) proteins of influenza B viruses isolated from 1940 to 1998 were analyzed in a parallel manner in order to understand the evolutionary mechanisms of these viruses. Unlike human influenza A (H3N2) viruses, the evolutionary pathways of all four genes of recent influenza B viruses revealed similar patterns of genetic divergence into two major lineages. Although evolutionary rates of the HA, NP, M, and NS genes of influenza B viruses were estimated to be generally lower than those of human influenza A viruses, genes of influenza B viruses demonstrated complex phylogenetic patterns, indicating alternative mechanisms for generation of virus variability. Topologies of the evolutionary trees of each gene were determined to be quite distinct from one another, showing that these genes were evolving in an independent manner. Furthermore, variable topologies were apparently the result of frequent genetic exchange among cocirculating epidemic viruses. Evolutionary analysis done in the present study provided further evidence for cocirculation of multiple lineages as well as sequestering and reemergence of phylogenetic lineages of the internal genes. In addition, comparison of deduced amino acid sequences revealed a novel amino acid deletion in the HA1 domain of the HA protein of recent isolates from 1998 belonging to the B/Yamagata/16/88-like lineage. It thus became apparent that, despite lower evolutionary rates, influenza B viruses were able to generate genetic diversity among circulating viruses through a combination of evolutionary mechanisms involving cocirculating lineages and genetic reassortment by which new variants with distinct gene constellations emerged.
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PubMed: 10196339
PubMed Central: 104222
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PMC:104222Le document en format XML
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<author><name sortKey="Lindstrom, Stephen E" sort="Lindstrom, Stephen E" uniqKey="Lindstrom S" first="Stephen E." last="Lindstrom">Stephen E. Lindstrom</name>
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<author><name sortKey="Hiromoto, Yasuaki" sort="Hiromoto, Yasuaki" uniqKey="Hiromoto Y" first="Yasuaki" last="Hiromoto">Yasuaki Hiromoto</name>
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<author><name sortKey="Nishimura, Hidekazu" sort="Nishimura, Hidekazu" uniqKey="Nishimura H" first="Hidekazu" last="Nishimura">Hidekazu Nishimura</name>
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<author><name sortKey="Saito, Takehiko" sort="Saito, Takehiko" uniqKey="Saito T" first="Takehiko" last="Saito">Takehiko Saito</name>
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<author><name sortKey="Nerome, Reiko" sort="Nerome, Reiko" uniqKey="Nerome R" first="Reiko" last="Nerome">Reiko Nerome</name>
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<author><name sortKey="Nerome, Kuniaki" sort="Nerome, Kuniaki" uniqKey="Nerome K" first="Kuniaki" last="Nerome">Kuniaki Nerome</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparative Analysis of Evolutionary Mechanisms of the Hemagglutinin and Three Internal Protein Genes of Influenza B Virus: Multiple Cocirculating Lineages and Frequent Reassortment of the NP, M, and NS Genes</title>
<author><name sortKey="Lindstrom, Stephen E" sort="Lindstrom, Stephen E" uniqKey="Lindstrom S" first="Stephen E." last="Lindstrom">Stephen E. Lindstrom</name>
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<author><name sortKey="Hiromoto, Yasuaki" sort="Hiromoto, Yasuaki" uniqKey="Hiromoto Y" first="Yasuaki" last="Hiromoto">Yasuaki Hiromoto</name>
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<author><name sortKey="Nishimura, Hidekazu" sort="Nishimura, Hidekazu" uniqKey="Nishimura H" first="Hidekazu" last="Nishimura">Hidekazu Nishimura</name>
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<author><name sortKey="Saito, Takehiko" sort="Saito, Takehiko" uniqKey="Saito T" first="Takehiko" last="Saito">Takehiko Saito</name>
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<author><name sortKey="Nerome, Reiko" sort="Nerome, Reiko" uniqKey="Nerome R" first="Reiko" last="Nerome">Reiko Nerome</name>
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<author><name sortKey="Nerome, Kuniaki" sort="Nerome, Kuniaki" uniqKey="Nerome K" first="Kuniaki" last="Nerome">Kuniaki Nerome</name>
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<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
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<front><div type="abstract" xml:lang="en"><p>Phylogenetic profiles of the genes coding for the hemagglutinin (HA) protein, nucleoprotein (NP), matrix (M) protein, and nonstructural (NS) proteins of influenza B viruses isolated from 1940 to 1998 were analyzed in a parallel manner in order to understand the evolutionary mechanisms of these viruses. Unlike human influenza A (H3N2) viruses, the evolutionary pathways of all four genes of recent influenza B viruses revealed similar patterns of genetic divergence into two major lineages. Although evolutionary rates of the HA, NP, M, and NS genes of influenza B viruses were estimated to be generally lower than those of human influenza A viruses, genes of influenza B viruses demonstrated complex phylogenetic patterns, indicating alternative mechanisms for generation of virus variability. Topologies of the evolutionary trees of each gene were determined to be quite distinct from one another, showing that these genes were evolving in an independent manner. Furthermore, variable topologies were apparently the result of frequent genetic exchange among cocirculating epidemic viruses. Evolutionary analysis done in the present study provided further evidence for cocirculation of multiple lineages as well as sequestering and reemergence of phylogenetic lineages of the internal genes. In addition, comparison of deduced amino acid sequences revealed a novel amino acid deletion in the HA1 domain of the HA protein of recent isolates from 1998 belonging to the B/Yamagata/16/88-like lineage. It thus became apparent that, despite lower evolutionary rates, influenza B viruses were able to generate genetic diversity among circulating viruses through a combination of evolutionary mechanisms involving cocirculating lineages and genetic reassortment by which new variants with distinct gene constellations emerged.</p>
</div>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id>
<journal-id journal-id-type="publisher-id">J VIROL</journal-id>
<journal-title>Journal of Virology</journal-title>
<issn pub-type="ppub">0022-538X</issn>
<issn pub-type="epub">1098-5514</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
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<article-meta><article-id pub-id-type="pmid">10196339</article-id>
<article-id pub-id-type="pmc">104222</article-id>
<article-id pub-id-type="publisher-id">2074</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Recombination and Evolution</subject>
</subj-group>
</article-categories>
<title-group><article-title>Comparative Analysis of Evolutionary Mechanisms of the Hemagglutinin and Three Internal Protein Genes of Influenza B Virus: Multiple Cocirculating Lineages and Frequent Reassortment of the NP, M, and NS Genes</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lindstrom</surname>
<given-names>Stephen E.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hiromoto</surname>
<given-names>Yasuaki</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Nishimura</surname>
<given-names>Hidekazu</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Saito</surname>
<given-names>Takehiko</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Nerome</surname>
<given-names>Reiko</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Nerome</surname>
<given-names>Kuniaki</given-names>
</name>
<xref ref-type="author-notes" rid="FN150">*</xref>
</contrib>
</contrib-group>
<aff id="N0x8b86230.0x9fb0398">Department of Virology I, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan</aff>
<author-notes><fn id="FN150"><label>*</label>
<p>Corresponding author. Mailing address: Department of Virology I, National Institute of Infectious Diseases, 23-1, Toyama 1-chome, Shinjuku-ku, Tokyo 162-8640, Japan. Phone: (03) 5285-1111. Fax: (03) 5285-1155. E-mail: <email>knerome@nih.go.jp</email>
.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>5</month>
<year>1999</year>
</pub-date>
<volume>73</volume>
<issue>5</issue>
<fpage>4413</fpage>
<lpage>4426</lpage>
<history><date date-type="received"><day>9</day>
<month>12</month>
<year>1998</year>
</date>
<date date-type="accepted"><day>9</day>
<month>2</month>
<year>1999</year>
</date>
</history>
<copyright-statement>Copyright © 1999, American Society for Microbiology</copyright-statement>
<copyright-year>1999</copyright-year>
<abstract><p>Phylogenetic profiles of the genes coding for the hemagglutinin (HA) protein, nucleoprotein (NP), matrix (M) protein, and nonstructural (NS) proteins of influenza B viruses isolated from 1940 to 1998 were analyzed in a parallel manner in order to understand the evolutionary mechanisms of these viruses. Unlike human influenza A (H3N2) viruses, the evolutionary pathways of all four genes of recent influenza B viruses revealed similar patterns of genetic divergence into two major lineages. Although evolutionary rates of the HA, NP, M, and NS genes of influenza B viruses were estimated to be generally lower than those of human influenza A viruses, genes of influenza B viruses demonstrated complex phylogenetic patterns, indicating alternative mechanisms for generation of virus variability. Topologies of the evolutionary trees of each gene were determined to be quite distinct from one another, showing that these genes were evolving in an independent manner. Furthermore, variable topologies were apparently the result of frequent genetic exchange among cocirculating epidemic viruses. Evolutionary analysis done in the present study provided further evidence for cocirculation of multiple lineages as well as sequestering and reemergence of phylogenetic lineages of the internal genes. In addition, comparison of deduced amino acid sequences revealed a novel amino acid deletion in the HA1 domain of the HA protein of recent isolates from 1998 belonging to the B/Yamagata/16/88-like lineage. It thus became apparent that, despite lower evolutionary rates, influenza B viruses were able to generate genetic diversity among circulating viruses through a combination of evolutionary mechanisms involving cocirculating lineages and genetic reassortment by which new variants with distinct gene constellations emerged.</p>
</abstract>
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