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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rapid Evolution of H5N1 Influenza Viruses in Chickens in Hong Kong</title><author><name sortKey="Zhou, Nan Nan" sort="Zhou, Nan Nan" uniqKey="Zhou N" first="Nan Nan" last="Zhou">Nan Nan Zhou</name><affiliation><nlm:aff id="N0x9ccbab8.0x9cb17d8"></nlm:aff></affiliation><affiliation><nlm:aff id="N0x9ccbab8.0x9cb17d8"></nlm:aff></affiliation></author><author><name sortKey="Shortridge, Kennedy F" sort="Shortridge, Kennedy F" uniqKey="Shortridge K" first="Kennedy F." last="Shortridge">Kennedy F. Shortridge</name><affiliation><nlm:aff id="N0x9ccbab8.0x9cb17d8"></nlm:aff></affiliation></author><author><name sortKey="Claas, Eric C J" sort="Claas, Eric C J" uniqKey="Claas E" first="Eric C. J." last="Claas">Eric C. J. Claas</name><affiliation><nlm:aff id="N0x9ccbab8.0x9cb17d8"></nlm:aff></affiliation></author><author><name sortKey="Krauss, Scott L" sort="Krauss, Scott L" uniqKey="Krauss S" first="Scott L." last="Krauss">Scott L. Krauss</name><affiliation><nlm:aff id="N0x9ccbab8.0x9cb17d8"></nlm:aff></affiliation></author><author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name><affiliation><nlm:aff id="N0x9ccbab8.0x9cb17d8"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">10074191</idno><idno type="pmc">104101</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC104101</idno><idno type="RBID">PMC:104101</idno><date when="1999">1999</date><idno type="wicri:Area/Pmc/Corpus">000132</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000132</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Rapid Evolution of H5N1 Influenza Viruses in Chickens in Hong Kong</title><author><name sortKey="Zhou, Nan Nan" sort="Zhou, Nan Nan" uniqKey="Zhou N" first="Nan Nan" last="Zhou">Nan Nan Zhou</name><affiliation><nlm:aff id="N0x9ccbab8.0x9cb17d8"></nlm:aff></affiliation><affiliation><nlm:aff id="N0x9ccbab8.0x9cb17d8"></nlm:aff></affiliation></author><author><name sortKey="Shortridge, Kennedy F" sort="Shortridge, Kennedy F" uniqKey="Shortridge K" first="Kennedy F." last="Shortridge">Kennedy F. Shortridge</name><affiliation><nlm:aff id="N0x9ccbab8.0x9cb17d8"></nlm:aff></affiliation></author><author><name sortKey="Claas, Eric C J" sort="Claas, Eric C J" uniqKey="Claas E" first="Eric C. J." last="Claas">Eric C. J. Claas</name><affiliation><nlm:aff id="N0x9ccbab8.0x9cb17d8"></nlm:aff></affiliation></author><author><name sortKey="Krauss, Scott L" sort="Krauss, Scott L" uniqKey="Krauss S" first="Scott L." last="Krauss">Scott L. Krauss</name><affiliation><nlm:aff id="N0x9ccbab8.0x9cb17d8"></nlm:aff></affiliation></author><author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name><affiliation><nlm:aff id="N0x9ccbab8.0x9cb17d8"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="1999">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The H5N1 avian influenza virus that killed 6 of 18 persons infected in Hong Kong in 1997 was transmitted directly from poultry to humans. Viral isolates from this outbreak may provide molecular clues to zoonotic transfer. Here we demonstrate that the H5N1 viruses circulating in poultry comprised two distinguishable phylogenetic lineages in all genes that were in very rapid evolution. When introduced into new hosts, influenza viruses usually undergo rapid alteration of their surface glycoproteins, especially in the hemagglutinin (HA). Surprisingly, these H5N1 isolates had a large proportion of amino acid changes in all gene products except in the HA. These viruses maybe reassortants each of whose HA gene is well adapted to domestic poultry while the rest of the genome arises from a different source. The consensus amino acid sequences of “internal” virion proteins reveal amino acids previously found in human strains. These human-specific amino acids may be important factors in zoonotic transmission.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="publisher-id">J VIROL</journal-id><journal-title>Journal of Virology</journal-title><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">10074191</article-id><article-id pub-id-type="pmc">104101</article-id><article-id pub-id-type="publisher-id">1729</article-id><article-categories><subj-group subj-group-type="heading"><subject>Recombination and Evolution</subject></subj-group></article-categories><title-group><article-title>Rapid Evolution of H5N1 Influenza Viruses in Chickens in Hong Kong</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Nan Nan</given-names></name><xref ref-type="aff" rid="N0x9ccbab8.0x9cb17d8">1</xref><xref ref-type="aff" rid="N0x9ccbab8.0x9cb17d8">2</xref></contrib><contrib contrib-type="author"><name><surname>Shortridge</surname><given-names>Kennedy F.</given-names></name><xref ref-type="aff" rid="N0x9ccbab8.0x9cb17d8">3</xref></contrib><contrib contrib-type="author"><name><surname>Claas</surname><given-names>Eric C. J.</given-names></name><xref ref-type="aff" rid="N0x9ccbab8.0x9cb17d8">4</xref></contrib><contrib contrib-type="author"><name><surname>Krauss</surname><given-names>Scott L.</given-names></name><xref ref-type="aff" rid="N0x9ccbab8.0x9cb17d8">1</xref></contrib><contrib contrib-type="author"><name><surname>Webster</surname><given-names>Robert G.</given-names></name><xref ref-type="aff" rid="N0x9ccbab8.0x9cb17d8">1</xref><xref ref-type="author-notes" rid="FN150">*</xref></contrib></contrib-group><aff id="N0x9ccbab8.0x9cb17d8"> Department of Virology and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105<sup>1</sup>; Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong,<sup>3</sup> and Department of Microbiology, Jiangxi Medical College, Nanchang,<sup>2</sup> People’s Republic of China; and Department of Virology, Leiden University Medical Center, Leiden, The Netherlands<sup>4</sup></aff><author-notes><fn id="FN150"><label>*</label><p>Corresponding author. Mailing address: Department of Virology and Molecular Biology, St. Jude Children’s Research Hospital, 332 N. Lauderdale, Memphis, TN 38105. Phone: (901) 495-3400. Fax: (901) 523-2622. E-mail: <email>robert.webster@stjude.org</email>.</p></fn></author-notes><pub-date pub-type="ppub"><month>4</month><year>1999</year></pub-date><volume>73</volume><issue>4</issue><fpage>3366</fpage><lpage>3374</lpage><history><date date-type="received"><day>9</day><month>10</month><year>1998</year></date><date date-type="accepted"><day>4</day><month>1</month><year>1999</year></date></history><copyright-statement>Copyright © 1999, American Society for Microbiology</copyright-statement><copyright-year>1999</copyright-year><abstract><p>The H5N1 avian influenza virus that killed 6 of 18 persons infected in Hong Kong in 1997 was transmitted directly from poultry to humans. Viral isolates from this outbreak may provide molecular clues to zoonotic transfer. Here we demonstrate that the H5N1 viruses circulating in poultry comprised two distinguishable phylogenetic lineages in all genes that were in very rapid evolution. When introduced into new hosts, influenza viruses usually undergo rapid alteration of their surface glycoproteins, especially in the hemagglutinin (HA). Surprisingly, these H5N1 isolates had a large proportion of amino acid changes in all gene products except in the HA. These viruses maybe reassortants each of whose HA gene is well adapted to domestic poultry while the rest of the genome arises from a different source. The consensus amino acid sequences of “internal” virion proteins reveal amino acids previously found in human strains. These human-specific amino acids may be important factors in zoonotic transmission.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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