Serveur d'exploration H2N2

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<title xml:lang="en">H7N9 influenza virus neutralizing antibodies that possess few somatic mutations</title>
<author>
<name sortKey="Thornburg, Natalie J" sort="Thornburg, Natalie J" uniqKey="Thornburg N" first="Natalie J." last="Thornburg">Natalie J. Thornburg</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zhang, Heng" sort="Zhang, Heng" uniqKey="Zhang H" first="Heng" last="Zhang">Heng Zhang</name>
<affiliation>
<nlm:aff id="A3">Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bangaru, Sandhya" sort="Bangaru, Sandhya" uniqKey="Bangaru S" first="Sandhya" last="Bangaru">Sandhya Bangaru</name>
<affiliation>
<nlm:aff wicri:cut=", and" id="A4">Departments of Pathology, Microbiology, and Immunology</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sapparapu, Gopal" sort="Sapparapu, Gopal" uniqKey="Sapparapu G" first="Gopal" last="Sapparapu">Gopal Sapparapu</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kose, Nurgun" sort="Kose, Nurgun" uniqKey="Kose N" first="Nurgun" last="Kose">Nurgun Kose</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lampley, Rebecca M" sort="Lampley, Rebecca M" uniqKey="Lampley R" first="Rebecca M." last="Lampley">Rebecca M. Lampley</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bombardi, Robin G" sort="Bombardi, Robin G" uniqKey="Bombardi R" first="Robin G." last="Bombardi">Robin G. Bombardi</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yu, Yingchun" sort="Yu, Yingchun" uniqKey="Yu Y" first="Yingchun" last="Yu">Yingchun Yu</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Graham, Stephen" sort="Graham, Stephen" uniqKey="Graham S" first="Stephen" last="Graham">Stephen Graham</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Branchizio, Andre" sort="Branchizio, Andre" uniqKey="Branchizio A" first="Andre" last="Branchizio">Andre Branchizio</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yoder, Sandra M" sort="Yoder, Sandra M" uniqKey="Yoder S" first="Sandra M." last="Yoder">Sandra M. Yoder</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A5">Vanderbilt Vaccine Research Program, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rock, Michael T" sort="Rock, Michael T" uniqKey="Rock M" first="Michael T." last="Rock">Michael T. Rock</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A5">Vanderbilt Vaccine Research Program, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Creech, C Buddy" sort="Creech, C Buddy" uniqKey="Creech C" first="C. Buddy" last="Creech">C. Buddy Creech</name>
<affiliation>
<nlm:aff id="A2">Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A5">Vanderbilt Vaccine Research Program, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M." last="Edwards">Kathryn M. Edwards</name>
<affiliation>
<nlm:aff id="A2">Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A5">Vanderbilt Vaccine Research Program, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lee, David" sort="Lee, David" uniqKey="Lee D" first="David" last="Lee">David Lee</name>
<affiliation>
<nlm:aff id="A6">Department of Medicine and Biomedical Sciences Graduate Program, School of Medicine, UCSD, San Diego, California, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Li, Sheng" sort="Li, Sheng" uniqKey="Li S" first="Sheng" last="Li">Sheng Li</name>
<affiliation>
<nlm:aff id="A6">Department of Medicine and Biomedical Sciences Graduate Program, School of Medicine, UCSD, San Diego, California, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name>
<affiliation>
<nlm:aff id="A3">Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name>
<affiliation>
<nlm:aff id="A7">Department of Microbiology,</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff wicri:cut=", and" id="A8">Global Health and Emerging Pathogens Institute</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A9">Department of Medicine, Division of Infectious Diseases at Icahn School of Medicine at Mount Sinai (ISMMS), New York, New York, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Albrecht, Randy A" sort="Albrecht, Randy A" uniqKey="Albrecht R" first="Randy A." last="Albrecht">Randy A. Albrecht</name>
<affiliation>
<nlm:aff id="A7">Department of Microbiology,</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff wicri:cut=", and" id="A8">Global Health and Emerging Pathogens Institute</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff wicri:cut=", and" id="A4">Departments of Pathology, Microbiology, and Immunology</nlm:aff>
</affiliation>
</author>
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<idno type="pmid">26950424</idno>
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<idno type="RBID">PMC:4811156</idno>
<idno type="doi">10.1172/JCI85317</idno>
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<title xml:lang="en" level="a" type="main">H7N9 influenza virus neutralizing antibodies that possess few somatic mutations</title>
<author>
<name sortKey="Thornburg, Natalie J" sort="Thornburg, Natalie J" uniqKey="Thornburg N" first="Natalie J." last="Thornburg">Natalie J. Thornburg</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zhang, Heng" sort="Zhang, Heng" uniqKey="Zhang H" first="Heng" last="Zhang">Heng Zhang</name>
<affiliation>
<nlm:aff id="A3">Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bangaru, Sandhya" sort="Bangaru, Sandhya" uniqKey="Bangaru S" first="Sandhya" last="Bangaru">Sandhya Bangaru</name>
<affiliation>
<nlm:aff wicri:cut=", and" id="A4">Departments of Pathology, Microbiology, and Immunology</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Sapparapu, Gopal" sort="Sapparapu, Gopal" uniqKey="Sapparapu G" first="Gopal" last="Sapparapu">Gopal Sapparapu</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kose, Nurgun" sort="Kose, Nurgun" uniqKey="Kose N" first="Nurgun" last="Kose">Nurgun Kose</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lampley, Rebecca M" sort="Lampley, Rebecca M" uniqKey="Lampley R" first="Rebecca M." last="Lampley">Rebecca M. Lampley</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bombardi, Robin G" sort="Bombardi, Robin G" uniqKey="Bombardi R" first="Robin G." last="Bombardi">Robin G. Bombardi</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yu, Yingchun" sort="Yu, Yingchun" uniqKey="Yu Y" first="Yingchun" last="Yu">Yingchun Yu</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Graham, Stephen" sort="Graham, Stephen" uniqKey="Graham S" first="Stephen" last="Graham">Stephen Graham</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Branchizio, Andre" sort="Branchizio, Andre" uniqKey="Branchizio A" first="Andre" last="Branchizio">Andre Branchizio</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Yoder, Sandra M" sort="Yoder, Sandra M" uniqKey="Yoder S" first="Sandra M." last="Yoder">Sandra M. Yoder</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A5">Vanderbilt Vaccine Research Program, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rock, Michael T" sort="Rock, Michael T" uniqKey="Rock M" first="Michael T." last="Rock">Michael T. Rock</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A5">Vanderbilt Vaccine Research Program, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Creech, C Buddy" sort="Creech, C Buddy" uniqKey="Creech C" first="C. Buddy" last="Creech">C. Buddy Creech</name>
<affiliation>
<nlm:aff id="A2">Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A5">Vanderbilt Vaccine Research Program, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M." last="Edwards">Kathryn M. Edwards</name>
<affiliation>
<nlm:aff id="A2">Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A5">Vanderbilt Vaccine Research Program, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Lee, David" sort="Lee, David" uniqKey="Lee D" first="David" last="Lee">David Lee</name>
<affiliation>
<nlm:aff id="A6">Department of Medicine and Biomedical Sciences Graduate Program, School of Medicine, UCSD, San Diego, California, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Li, Sheng" sort="Li, Sheng" uniqKey="Li S" first="Sheng" last="Li">Sheng Li</name>
<affiliation>
<nlm:aff id="A6">Department of Medicine and Biomedical Sciences Graduate Program, School of Medicine, UCSD, San Diego, California, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name>
<affiliation>
<nlm:aff id="A3">Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name>
<affiliation>
<nlm:aff id="A7">Department of Microbiology,</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff wicri:cut=", and" id="A8">Global Health and Emerging Pathogens Institute</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A9">Department of Medicine, Division of Infectious Diseases at Icahn School of Medicine at Mount Sinai (ISMMS), New York, New York, USA.</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Albrecht, Randy A" sort="Albrecht, Randy A" uniqKey="Albrecht R" first="Randy A." last="Albrecht">Randy A. Albrecht</name>
<affiliation>
<nlm:aff id="A7">Department of Microbiology,</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff wicri:cut=", and" id="A8">Global Health and Emerging Pathogens Institute</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name>
<affiliation>
<nlm:aff wicri:cut=" and" id="A1">The Vanderbilt Vaccine Center</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff wicri:cut=", and" id="A4">Departments of Pathology, Microbiology, and Immunology</nlm:aff>
</affiliation>
</author>
</analytic>
<series>
<title level="j">The Journal of Clinical Investigation</title>
<idno type="ISSN">0021-9738</idno>
<idno type="eISSN">1558-8238</idno>
<imprint>
<date when="????">????</date>
</imprint>
</series>
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<front>
<div type="abstract" xml:lang="en">
<p>Avian H7N9 influenza viruses are group 2 influenza A viruses that have been identified as the etiologic agent for a current major outbreak that began in China in 2013 and may pose a pandemic threat. Here, we examined the human H7-reactive antibody response in 75 recipients of a monovalent inactivated A/Shanghai/02/2013 H7N9 vaccine. After 2 doses of vaccine, the majority of donors had memory B cells that secreted IgGs specific for H7 HA, with dominant responses against single HA subtypes, although frequencies of H7-reactive B cells ranged widely between donors. We isolated 12 naturally occurring mAbs with low half-maximal effective concentrations for binding, 5 of which possessed neutralizing and HA-inhibiting activities. The 5 neutralizing mAbs exhibited narrow breadth of reactivity with influenza H7 strains. Epitope-mapping studies using neutralization escape mutant analysis, deuterium exchange mass spectrometry, and x-ray crystallography revealed that these neutralizing mAbs bind near the receptor-binding pocket on HA. All 5 neutralizing mAbs possessed low numbers of somatic mutations, suggesting the clones arose from naive B cells. The most potent mAb, H7.167, was tested as a prophylactic treatment in a mouse intranasal virus challenge study, and systemic administration of the mAb markedly reduced viral lung titers.</p>
</div>
</front>
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<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">J Clin Invest</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Clin. Invest</journal-id>
<journal-id journal-id-type="publisher-id">J Clin Invest</journal-id>
<journal-title-group>
<journal-title>The Journal of Clinical Investigation</journal-title>
</journal-title-group>
<issn pub-type="ppub">0021-9738</issn>
<issn pub-type="epub">1558-8238</issn>
<publisher>
<publisher-name>American Society for Clinical Investigation</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">26950424</article-id>
<article-id pub-id-type="pmc">4811156</article-id>
<article-id pub-id-type="publisher-id">85317</article-id>
<article-id pub-id-type="doi">10.1172/JCI85317</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>H7N9 influenza virus neutralizing antibodies that possess few somatic mutations</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Thornburg</surname>
<given-names>Natalie J.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhang</surname>
<given-names>Heng</given-names>
</name>
<email>zhangh@scripps.edu</email>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bangaru</surname>
<given-names>Sandhya</given-names>
</name>
<email>sandhya.bangaru@Vanderbilt.Edu</email>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author">
<contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0001-9670-1757</contrib-id>
<name>
<surname>Sapparapu</surname>
<given-names>Gopal</given-names>
</name>
<email>gopal.sapparapu@Vanderbilt.Edu</email>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kose</surname>
<given-names>Nurgun</given-names>
</name>
<email>nurgun.kose@Vanderbilt.Edu</email>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lampley</surname>
<given-names>Rebecca M.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bombardi</surname>
<given-names>Robin G.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yu</surname>
<given-names>Yingchun</given-names>
</name>
<email>yuantou8@gmail.com</email>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Graham</surname>
<given-names>Stephen</given-names>
</name>
<email>sdgraham118@gmail.com</email>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Branchizio</surname>
<given-names>Andre</given-names>
</name>
<email>andre.j.branchizio@Vanderbilt.Edu</email>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yoder</surname>
<given-names>Sandra M.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Rock</surname>
<given-names>Michael T.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Creech</surname>
<given-names>C. Buddy</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Edwards</surname>
<given-names>Kathryn M.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lee</surname>
<given-names>David</given-names>
</name>
<email>David.Lee@med.wmich.edu</email>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Li</surname>
<given-names>Sheng</given-names>
</name>
<email>s4li@ucsd.edu</email>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wilson</surname>
<given-names>Ian A.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>García-Sastre</surname>
<given-names>Adolfo</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Albrecht</surname>
<given-names>Randy A.</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Crowe</surname>
<given-names>James E.</given-names>
<suffix>Jr.</suffix>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
</contrib-group>
<aff id="A1">
<label>1</label>
The Vanderbilt Vaccine Center and</aff>
<aff id="A2">
<label>2</label>
Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA.</aff>
<aff id="A3">
<label>3</label>
Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA.</aff>
<aff id="A4">
<label>4</label>
Departments of Pathology, Microbiology, and Immunology, and</aff>
<aff id="A5">
<label>5</label>
Vanderbilt Vaccine Research Program, Vanderbilt University, Nashville, Tennessee, USA.</aff>
<aff id="A6">
<label>6</label>
Department of Medicine and Biomedical Sciences Graduate Program, School of Medicine, UCSD, San Diego, California, USA.</aff>
<aff id="A7">
<label>7</label>
Department of Microbiology,</aff>
<aff id="A8">
<label>8</label>
Global Health and Emerging Pathogens Institute, and</aff>
<aff id="A9">
<label>9</label>
Department of Medicine, Division of Infectious Diseases at Icahn School of Medicine at Mount Sinai (ISMMS), New York, New York, USA.</aff>
<author-notes>
<corresp>Address correspondence to: James E. Crowe Jr., Vanderbilt Vaccine Center, Vanderbilt University Medical Center, 11475 MRB IV, 2213 Garland Avenue, Nashville, Tennessee 37232-0417, USA. Phone: 615.343.8064; E-mail:
<email>james.crowe@vanderbilt.edu</email>
.</corresp>
</author-notes>
<pub-date date-type="pub" publication-format="electronic" iso-8601-date="2016-03-07">
<day>7</day>
<month>3</month>
<year>2016</year>
</pub-date>
<pub-date date-type="pub" publication-format="print" iso-8601-date="2016-04-01">
<day>1</day>
<month>4</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>1</day>
<month>7</month>
<year>2016</year>
</pub-date>
<pmc-comment> PMC Release delay is 3 months and 0 days and was based on the . </pmc-comment>
<volume>126</volume>
<issue>4</issue>
<fpage>1482</fpage>
<lpage>1494</lpage>
<history>
<date date-type="received">
<day>30</day>
<month>10</month>
<year>2015</year>
</date>
<date date-type="accepted">
<day>21</day>
<month>1</month>
<year>2016</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright © 2016, American Society for Clinical Investigation</copyright-statement>
<copyright-year>2016</copyright-year>
<copyright-holder>American Society for Clinical Investigation</copyright-holder>
</permissions>
<self-uri xlink:href="https://www.jci.org/articles/view/85317">This article is available online at https://www.jci.org/articles/view/85317</self-uri>
<abstract>
<p>Avian H7N9 influenza viruses are group 2 influenza A viruses that have been identified as the etiologic agent for a current major outbreak that began in China in 2013 and may pose a pandemic threat. Here, we examined the human H7-reactive antibody response in 75 recipients of a monovalent inactivated A/Shanghai/02/2013 H7N9 vaccine. After 2 doses of vaccine, the majority of donors had memory B cells that secreted IgGs specific for H7 HA, with dominant responses against single HA subtypes, although frequencies of H7-reactive B cells ranged widely between donors. We isolated 12 naturally occurring mAbs with low half-maximal effective concentrations for binding, 5 of which possessed neutralizing and HA-inhibiting activities. The 5 neutralizing mAbs exhibited narrow breadth of reactivity with influenza H7 strains. Epitope-mapping studies using neutralization escape mutant analysis, deuterium exchange mass spectrometry, and x-ray crystallography revealed that these neutralizing mAbs bind near the receptor-binding pocket on HA. All 5 neutralizing mAbs possessed low numbers of somatic mutations, suggesting the clones arose from naive B cells. The most potent mAb, H7.167, was tested as a prophylactic treatment in a mouse intranasal virus challenge study, and systemic administration of the mAb markedly reduced viral lung titers.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>

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