H2N2V1, Pmc, Corpus, bibRecord, 000016

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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference</title>
<author><name sortKey="Wang, Fei" sort="Wang, Fei" uniqKey="Wang F" first="Fei" last="Wang">Fei Wang</name>
<affiliation><nlm:aff id="au1"><institution>College of Veterinary Medicine, China Agricultural University</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Qi, Jianxun" sort="Qi, Jianxun" uniqKey="Qi J" first="Jianxun" last="Qi">Jianxun Qi</name>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bi, Yuhai" sort="Bi, Yuhai" uniqKey="Bi Y" first="Yuhai" last="Bi">Yuhai Bi</name>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name>
<affiliation><nlm:aff id="au1"><institution>College of Veterinary Medicine, China Agricultural University</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhang, Baorong" sort="Zhang, Baorong" uniqKey="Zhang B" first="Baorong" last="Zhang">Baorong Zhang</name>
<affiliation><nlm:aff id="au4"><institution>Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au5"><institution>Aviation General Hospital</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name>
<affiliation><nlm:aff id="au1"><institution>College of Veterinary Medicine, China Agricultural University</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liu, Jinhua" sort="Liu, Jinhua" uniqKey="Liu J" first="Jinhua" last="Liu">Jinhua Liu</name>
<affiliation><nlm:aff id="au1"><institution>College of Veterinary Medicine, China Agricultural University</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yan, Jinghua" sort="Yan, Jinghua" uniqKey="Yan J" first="Jinghua" last="Yan">Jinghua Yan</name>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shi, Yi" sort="Shi, Yi" uniqKey="Shi Y" first="Yi" last="Shi">Yi Shi</name>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au4"><institution>Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F" last="Gao">George F. Gao</name>
<affiliation><nlm:aff id="au1"><institution>College of Veterinary Medicine, China Agricultural University</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au4"><institution>Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au6"><institution>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC)</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au7"><institution>Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC)</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25940072</idno>
<idno type="pmc">4475400</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475400</idno>
<idno type="RBID">PMC:4475400</idno>
<idno type="doi">10.15252/embj.201590960</idno>
<date when="2015">2015</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference</title>
<author><name sortKey="Wang, Fei" sort="Wang, Fei" uniqKey="Wang F" first="Fei" last="Wang">Fei Wang</name>
<affiliation><nlm:aff id="au1"><institution>College of Veterinary Medicine, China Agricultural University</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Qi, Jianxun" sort="Qi, Jianxun" uniqKey="Qi J" first="Jianxun" last="Qi">Jianxun Qi</name>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bi, Yuhai" sort="Bi, Yuhai" uniqKey="Bi Y" first="Yuhai" last="Bi">Yuhai Bi</name>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name>
<affiliation><nlm:aff id="au1"><institution>College of Veterinary Medicine, China Agricultural University</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhang, Baorong" sort="Zhang, Baorong" uniqKey="Zhang B" first="Baorong" last="Zhang">Baorong Zhang</name>
<affiliation><nlm:aff id="au4"><institution>Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au5"><institution>Aviation General Hospital</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name>
<affiliation><nlm:aff id="au1"><institution>College of Veterinary Medicine, China Agricultural University</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liu, Jinhua" sort="Liu, Jinhua" uniqKey="Liu J" first="Jinhua" last="Liu">Jinhua Liu</name>
<affiliation><nlm:aff id="au1"><institution>College of Veterinary Medicine, China Agricultural University</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yan, Jinghua" sort="Yan, Jinghua" uniqKey="Yan J" first="Jinghua" last="Yan">Jinghua Yan</name>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shi, Yi" sort="Shi, Yi" uniqKey="Shi Y" first="Yi" last="Shi">Yi Shi</name>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au4"><institution>Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F" last="Gao">George F. Gao</name>
<affiliation><nlm:aff id="au1"><institution>College of Veterinary Medicine, China Agricultural University</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au2"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au3"><institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au4"><institution>Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au6"><institution>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC)</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="au7"><institution>Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC)</institution>
<addr-line>Beijing, China</addr-line>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">The EMBO Journal</title>
<idno type="ISSN">0261-4189</idno>
<idno type="eISSN">1460-2075</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p>The receptor-binding specificity of influenza A viruses is a major determinant for the host tropism of the virus, which enables interspecies transmission. In 2013, the first human case of infection with avian influenza A (H6N1) virus was reported in Taiwan. To gather evidence concerning the epidemic potential of H6 subtype viruses, we performed comprehensive analysis of receptor-binding properties of Taiwan-isolated H6 HAs from 1972 to 2013. We propose that the receptor-binding properties of Taiwan-isolated H6 HAs have undergone three major stages: initially avian receptor-binding preference, secondarily obtaining human receptor-binding capacity, and recently human receptor-binding preference, which has been confirmed by receptor-binding assessment of three representative virus isolates. Mutagenesis work revealed that E190V and G228S substitutions are important to acquire the human receptor-binding capacity, and the P186L substitution could reduce the binding to avian receptor. Further structural analysis revealed how the P186L substitution in the receptor-binding site of HA determines the receptor-binding preference change. We conclude that the human-infecting H6N1 evolved into a human receptor preference.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">EMBO J</journal-id>
<journal-id journal-id-type="iso-abbrev">EMBO J</journal-id>
<journal-id journal-id-type="publisher-id">embj</journal-id>
<journal-title-group><journal-title>The EMBO Journal</journal-title>
</journal-title-group>
<issn pub-type="ppub">0261-4189</issn>
<issn pub-type="epub">1460-2075</issn>
<publisher><publisher-name>BlackWell Publishing Ltd</publisher-name>
<publisher-loc>Oxford, UK</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25940072</article-id>
<article-id pub-id-type="pmc">4475400</article-id>
<article-id pub-id-type="doi">10.15252/embj.201590960</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Fei</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="aff" rid="au2">2</xref>
<xref ref-type="author-notes" rid="fn1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Qi</surname>
<given-names>Jianxun</given-names>
</name>
<xref ref-type="aff" rid="au2">2</xref>
<xref ref-type="aff" rid="au3">3</xref>
<xref ref-type="author-notes" rid="fn1">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bi</surname>
<given-names>Yuhai</given-names>
</name>
<xref ref-type="aff" rid="au2">2</xref>
<xref ref-type="aff" rid="au3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Wei</given-names>
</name>
<xref ref-type="aff" rid="au2">2</xref>
<xref ref-type="aff" rid="au3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Min</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="aff" rid="au2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Baorong</given-names>
</name>
<xref ref-type="aff" rid="au4">4</xref>
<xref ref-type="aff" rid="au5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Ming</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Jinhua</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yan</surname>
<given-names>Jinghua</given-names>
</name>
<xref ref-type="aff" rid="au2">2</xref>
<xref ref-type="aff" rid="au3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shi</surname>
<given-names>Yi</given-names>
</name>
<xref ref-type="aff" rid="au2">2</xref>
<xref ref-type="aff" rid="au3">3</xref>
<xref ref-type="aff" rid="au4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gao</surname>
<given-names>George F</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="aff" rid="au2">2</xref>
<xref ref-type="aff" rid="au3">3</xref>
<xref ref-type="aff" rid="au4">4</xref>
<xref ref-type="aff" rid="au6">6</xref>
<xref ref-type="aff" rid="au7">7</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<aff id="au1"><label>1</label>
<institution>College of Veterinary Medicine, China Agricultural University</institution>
<addr-line>Beijing, China</addr-line>
</aff>
<aff id="au2"><label>2</label>
<institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</aff>
<aff id="au3"><label>3</label>
<institution>Center of Influenza Research and Early-Warning, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</aff>
<aff id="au4"><label>4</label>
<institution>Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences</institution>
<addr-line>Beijing, China</addr-line>
</aff>
<aff id="au5"><label>5</label>
<institution>Aviation General Hospital</institution>
<addr-line>Beijing, China</addr-line>
</aff>
<aff id="au6"><label>6</label>
<institution>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC)</institution>
<addr-line>Beijing, China</addr-line>
</aff>
<aff id="au7"><label>7</label>
<institution>Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC)</institution>
<addr-line>Beijing, China</addr-line>
</aff>
</contrib-group>
<author-notes><corresp id="cor1">*Corresponding author. Tel: +86 10 64807688; E-mail: <email>gaof@im.ac.cn</email>
</corresp>
<fn><p><bold>Subject Categories</bold>
 Microbiology, Virology & Host Pathogen Interaction</p>
</fn>
<fn id="fn1"><label>†</label>
<p>These authors contributed equally to this work</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>12</day>
<month>6</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>04</day>
<month>5</month>
<year>2015</year>
</pub-date>
<volume>34</volume>
<issue>12</issue>
<fpage>1661</fpage>
<lpage>1673</lpage>
<history><date date-type="received"><day>06</day>
<month>1</month>
<year>2015</year>
</date>
<date date-type="rev-recd"><day>10</day>
<month>4</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>16</day>
<month>4</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© 2015 The Authors</copyright-statement>
<copyright-year>2015</copyright-year>
</permissions>
<abstract><p>The receptor-binding specificity of influenza A viruses is a major determinant for the host tropism of the virus, which enables interspecies transmission. In 2013, the first human case of infection with avian influenza A (H6N1) virus was reported in Taiwan. To gather evidence concerning the epidemic potential of H6 subtype viruses, we performed comprehensive analysis of receptor-binding properties of Taiwan-isolated H6 HAs from 1972 to 2013. We propose that the receptor-binding properties of Taiwan-isolated H6 HAs have undergone three major stages: initially avian receptor-binding preference, secondarily obtaining human receptor-binding capacity, and recently human receptor-binding preference, which has been confirmed by receptor-binding assessment of three representative virus isolates. Mutagenesis work revealed that E190V and G228S substitutions are important to acquire the human receptor-binding capacity, and the P186L substitution could reduce the binding to avian receptor. Further structural analysis revealed how the P186L substitution in the receptor-binding site of HA determines the receptor-binding preference change. We conclude that the human-infecting H6N1 evolved into a human receptor preference.</p>
</abstract>
<kwd-group><kwd>crystal structure</kwd>
<kwd>H6N1</kwd>
<kwd>hemagglutinin</kwd>
<kwd>receptor binding</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

	Serveur d'exploration H2N2
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Serveur d'exploration H2N2

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