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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus</title><author><name sortKey="Van Poucke, Sjouke" sort="Van Poucke, Sjouke" uniqKey="Van Poucke S" first="Sjouke" last="Van Poucke">Sjouke Van Poucke</name><affiliation><nlm:aff id="aff1">Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium</nlm:aff></affiliation></author><author><name sortKey="Doedt, Jennifer" sort="Doedt, Jennifer" uniqKey="Doedt J" first="Jennifer" last="Doedt">Jennifer Doedt</name><affiliation><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Baumann, Jan" sort="Baumann, Jan" uniqKey="Baumann J" first="Jan" last="Baumann">Jan Baumann</name><affiliation><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Qiu, Yu" sort="Qiu, Yu" uniqKey="Qiu Y" first="Yu" last="Qiu">Yu Qiu</name><affiliation><nlm:aff id="aff1">Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium</nlm:aff></affiliation></author><author><name sortKey="Matrosovich, Tatyana" sort="Matrosovich, Tatyana" uniqKey="Matrosovich T" first="Tatyana" last="Matrosovich">Tatyana Matrosovich</name><affiliation><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name><affiliation><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Van Reeth, Kristien" sort="Van Reeth, Kristien" uniqKey="Van Reeth K" first="Kristien" last="Van Reeth">Kristien Van Reeth</name><affiliation><nlm:aff id="aff1">Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium</nlm:aff></affiliation></author><author><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name><affiliation><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26378170</idno><idno type="pmc">4645308</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645308</idno><idno type="RBID">PMC:4645308</idno><idno type="doi">10.1128/JVI.01292-15</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000013</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000013</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus</title><author><name sortKey="Van Poucke, Sjouke" sort="Van Poucke, Sjouke" uniqKey="Van Poucke S" first="Sjouke" last="Van Poucke">Sjouke Van Poucke</name><affiliation><nlm:aff id="aff1">Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium</nlm:aff></affiliation></author><author><name sortKey="Doedt, Jennifer" sort="Doedt, Jennifer" uniqKey="Doedt J" first="Jennifer" last="Doedt">Jennifer Doedt</name><affiliation><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Baumann, Jan" sort="Baumann, Jan" uniqKey="Baumann J" first="Jan" last="Baumann">Jan Baumann</name><affiliation><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Qiu, Yu" sort="Qiu, Yu" uniqKey="Qiu Y" first="Yu" last="Qiu">Yu Qiu</name><affiliation><nlm:aff id="aff1">Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium</nlm:aff></affiliation></author><author><name sortKey="Matrosovich, Tatyana" sort="Matrosovich, Tatyana" uniqKey="Matrosovich T" first="Tatyana" last="Matrosovich">Tatyana Matrosovich</name><affiliation><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name><affiliation><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Van Reeth, Kristien" sort="Van Reeth, Kristien" uniqKey="Van Reeth K" first="Kristien" last="Van Reeth">Kristien Van Reeth</name><affiliation><nlm:aff id="aff1">Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium</nlm:aff></affiliation></author><author><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name><affiliation><nlm:aff id="aff2">Institute of Virology, Philipps University, Marburg, Germany</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (positions 62, 81, 92, 144, and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.</p></div></front></TEI><pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="iso-abbrev">J. Virol</journal-id><journal-id journal-id-type="hwp">jvi</journal-id><journal-id journal-id-type="pmc">jvi</journal-id><journal-id journal-id-type="publisher-id">JVI</journal-id><journal-title-group><journal-title>Journal of Virology</journal-title></journal-title-group><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26378170</article-id><article-id pub-id-type="pmc">4645308</article-id><article-id pub-id-type="publisher-id">01292-15</article-id><article-id pub-id-type="doi">10.1128/JVI.01292-15</article-id><article-categories><subj-group subj-group-type="heading"><subject>Virus-Cell Interactions</subject></subj-group></article-categories><title-group><article-title>Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus</article-title><alt-title alt-title-type="running-head">Changes in the HA of the 1968 Pandemic Influenza Virus</alt-title><alt-title alt-title-type="short-authors">Van Poucke et al.</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Van Poucke</surname><given-names>Sjouke</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="author-notes" rid="fn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Doedt</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="author-notes" rid="fn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Baumann</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Qiu</surname><given-names>Yu</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Matrosovich</surname><given-names>Tatyana</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Klenk</surname><given-names>Hans-Dieter</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Van Reeth</surname><given-names>Kristien</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Matrosovich</surname><given-names>Mikhail</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><aff id="aff1"><label>a</label>Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium</aff><aff id="aff2"><label>b</label>Institute of Virology, Philipps University, Marburg, Germany</aff></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>García-Sastre</surname><given-names>A.</given-names></name><role>Editor</role></contrib></contrib-group><author-notes><corresp id="cor1">Address correspondence to Kristien Van Reeth, kristien. <email>vanreeth@ugent.be</email>, or Mikhail Matrosovich, <email>M.Matrosovich@gmail.com</email>.</corresp><fn id="fn1" fn-type="present-address"><label>*</label><p>Present address: Sjouke Van Poucke, Merial NV, Diegem, Belgium; Jennifer Doedt, Sividon Diagnostics GmbH, Cologne, Germany.</p></fn><fn fn-type="equal"><p>K.V.R. and M.M. contributed equally to this article.</p></fn><fn fn-type="other"><p><bold>Citation</bold> Van Poucke S, Doedt J, Baumann J, Qiu Y, Matrosovich T, Klenk H-D, Van Reeth K, Matrosovich M. 2015. Role of substitutions in the hemagglutinin in the emergence of the 1968 pandemic influenza virus. J Virol 89:12211–12216. doi:<ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1128/JVI.01292-15">10.1128/JVI.01292-15</ext-link>.</p></fn></author-notes><pub-date pub-type="epub"><day>16</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="collection"><day>1</day><month>12</month><year>2015</year></pub-date><volume>89</volume><issue>23</issue><fpage>12211</fpage><lpage>12216</lpage><history><date date-type="received"><day>22</day><month>5</month><year>2015</year></date><date date-type="accepted"><day>2</day><month>9</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015, American Society for Microbiology. All Rights Reserved.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>American Society for Microbiology</copyright-holder></permissions><self-uri content-type="pdf" xlink:href="zjv02315012211.pdf"></self-uri><abstract><p>Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (positions 62, 81, 92, 144, and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.</p></abstract><counts><fig-count count="4"></fig-count><table-count count="0"></table-count><equation-count count="0"></equation-count><ref-count count="40"></ref-count><page-count count="6"></page-count><word-count count="4391"></word-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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