Antibodies to human influenzavirus neuraminidase (the A/Asian/57 H2N2 strain) in sera from Australian pelagic birds*
Identifieur interne : 000E48 ( Pmc/Checkpoint ); précédent : 000E47; suivant : 000E49Antibodies to human influenzavirus neuraminidase (the A/Asian/57 H2N2 strain) in sera from Australian pelagic birds*
Auteurs : W. G. Laver ; R. G. WebsterSource :
- Bulletin of the World Health Organization [ 0042-9686 ] ; 1972.
Abstract
Sera collected from Australian pelagic birds specifically inhibited the neuraminidase of the Asian/57 (H2N2) strain of human influenzavirus. Neuraminidase inhibition titres of some sera were high and the avidity of the inhibitor was comparable to that of specific antibody. The neuraminidase of A/Hong Kong/1/68 (H3N2), which has undergone considerable antigenic drift in man since 1957, was inhibited to a lesser extent by the bird sera, while the neuraminidases of the A/BEL/42 (H0N1) and A/FM/1/47 (H1N1) strains were not inhibited at all. The inhibitor could be removed from the sera by adsorption with A/57 virus particles, but not by particles of A/BEL or A/FM1 viruses. These results suggested that the inhibitor in the bird sera was specific antibody. The antibodies to A/57 neuraminidase were found in sera from wedge-tailed shearwaters (
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PubMed: 4541008
PubMed Central: 2480857
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PMC:2480857Le document en format XML
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</title>
<author><name sortKey="Laver, W G" sort="Laver, W G" uniqKey="Laver W" first="W. G." last="Laver">W. G. Laver</name>
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<author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antibodies to human influenzavirus neuraminidase (the A/Asian/57 H2N2 strain) in sera from Australian pelagic birds<xref ref-type="fn" rid="fn1">*</xref>
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<author><name sortKey="Laver, W G" sort="Laver, W G" uniqKey="Laver W" first="W. G." last="Laver">W. G. Laver</name>
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<author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name>
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<series><title level="j">Bulletin of the World Health Organization</title>
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<imprint><date when="1972">1972</date>
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<front><div type="abstract" xml:lang="en"><p>Sera collected from Australian pelagic birds specifically inhibited the neuraminidase of the Asian/57 (H2N2) strain of human influenzavirus. Neuraminidase inhibition titres of some sera were high and the avidity of the inhibitor was comparable to that of specific antibody. The neuraminidase of A/Hong Kong/1/68 (H3N2), which has undergone considerable antigenic drift in man since 1957, was inhibited to a lesser extent by the bird sera, while the neuraminidases of the A/BEL/42 (H0N1) and A/FM/1/47 (H1N1) strains were not inhibited at all. The inhibitor could be removed from the sera by adsorption with A/57 virus particles, but not by particles of A/BEL or A/FM1 viruses. These results suggested that the inhibitor in the bird sera was specific antibody. The antibodies to A/57 neuraminidase were found in sera from wedge-tailed shearwaters (<italic>Puffinus pacificus</italic>
) and noddy terns (<italic>Anous minutus</italic>
) nesting on islands off the north-east coast of Australia. They were not found in sera from bridled terns (<italic>Sterna anaetheta</italic>
) or brown gannets (<italic>Sula leucogaster</italic>
) nesting on the same islands. Antibodies to A/57 neuraminidase were also detected in sera from short-tailed shearwaters (<italic>Puffinus tenuirostris</italic>
), which migrate around the Pacific Ocean, suggesting that these birds may be responsible for bringing avian influenzaviruses from areas in the Northern Hemisphere into Australian coastal waters.</p>
</div>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Bull World Health Organ</journal-id>
<journal-title>Bulletin of the World Health Organization</journal-title>
<issn pub-type="ppub">0042-9686</issn>
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<article-meta><article-id pub-id-type="pmid">4541008</article-id>
<article-id pub-id-type="pmc">2480857</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Antibodies to human influenzavirus neuraminidase (the A/Asian/57 H2N2 strain) in sera from Australian pelagic birds<xref ref-type="fn" rid="fn1">*</xref>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Laver</surname>
<given-names>W. G.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Webster</surname>
<given-names>R. G.</given-names>
</name>
</contrib>
</contrib-group>
<author-notes><fn id="fn1"><label>*</label>
<p>From the Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, Australia.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><year>1972</year>
</pub-date>
<volume>47</volume>
<issue>4</issue>
<fpage>535</fpage>
<lpage>541</lpage>
<abstract><p>Sera collected from Australian pelagic birds specifically inhibited the neuraminidase of the Asian/57 (H2N2) strain of human influenzavirus. Neuraminidase inhibition titres of some sera were high and the avidity of the inhibitor was comparable to that of specific antibody. The neuraminidase of A/Hong Kong/1/68 (H3N2), which has undergone considerable antigenic drift in man since 1957, was inhibited to a lesser extent by the bird sera, while the neuraminidases of the A/BEL/42 (H0N1) and A/FM/1/47 (H1N1) strains were not inhibited at all. The inhibitor could be removed from the sera by adsorption with A/57 virus particles, but not by particles of A/BEL or A/FM1 viruses. These results suggested that the inhibitor in the bird sera was specific antibody. The antibodies to A/57 neuraminidase were found in sera from wedge-tailed shearwaters (<italic>Puffinus pacificus</italic>
) and noddy terns (<italic>Anous minutus</italic>
) nesting on islands off the north-east coast of Australia. They were not found in sera from bridled terns (<italic>Sterna anaetheta</italic>
) or brown gannets (<italic>Sula leucogaster</italic>
) nesting on the same islands. Antibodies to A/57 neuraminidase were also detected in sera from short-tailed shearwaters (<italic>Puffinus tenuirostris</italic>
), which migrate around the Pacific Ocean, suggesting that these birds may be responsible for bringing avian influenzaviruses from areas in the Northern Hemisphere into Australian coastal waters.</p>
</abstract>
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</front>
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<name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name>
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