NS1 Proteins of Avian Influenza A Viruses Can Act as Antagonists of the Human Alpha/Beta Interferon Response▿
Identifieur interne : 000B93 ( Pmc/Checkpoint ); précédent : 000B92; suivant : 000B94NS1 Proteins of Avian Influenza A Viruses Can Act as Antagonists of the Human Alpha/Beta Interferon Response▿
Auteurs : A. Hayman ; S. Comely ; A. Lackenby ; L. C. S. Hartgroves ; S. Goodbourn ; J. W. Mccauley ; W. S. BarclaySource :
- Journal of Virology [ 0022-538X ] ; 2006.
Abstract
Many viruses, including human influenza A virus, have developed strategies for counteracting the host type I interferon (IFN) response. We have explored whether avian influenza viruses were less capable of combating the type I IFN response in mammalian cells, as this might be a determinant of host range restriction. A panel of avian influenza viruses isolated between 1927 and 1997 was assembled. The selected viruses showed variation in their ability to activate the expression of a reporter gene under the control of the IFN-β promoter and in the levels of IFN induced in mammalian cells. Surprisingly, the avian NS1 proteins expressed alone or in the genetic background of a human influenza virus controlled IFN-β induction in a manner similar to the NS1 protein of human strains. There was no direct correlation between the IFN-β induction and replication of avian influenza viruses in human A549 cells. Nevertheless, human cells deficient in the type I IFN system showed enhanced replication of the avian viruses studied, implying that the human type I IFN response limits avian influenza viruses and can contribute to host range restriction.
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DOI: 10.1128/JVI.01856-06
PubMed: 17182679
PubMed Central: 1865923
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Hayman</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Comely, S" sort="Comely, S" uniqKey="Comely S" first="S." last="Comely">S. Comely</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lackenby, A" sort="Lackenby, A" uniqKey="Lackenby A" first="A." last="Lackenby">A. Lackenby</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hartgroves, L C S" sort="Hartgroves, L C S" uniqKey="Hartgroves L" first="L. C. S." last="Hartgroves">L. C. S. Hartgroves</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Goodbourn, S" sort="Goodbourn, S" uniqKey="Goodbourn S" first="S." last="Goodbourn">S. Goodbourn</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Mccauley, J W" sort="Mccauley, J W" uniqKey="Mccauley J" first="J. W." last="Mccauley">J. W. Mccauley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Barclay, W S" sort="Barclay, W S" uniqKey="Barclay W" first="W. S." last="Barclay">W. S. Barclay</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Many viruses, including human influenza A virus, have developed strategies for counteracting the host type I interferon (IFN) response. We have explored whether avian influenza viruses were less capable of combating the type I IFN response in mammalian cells, as this might be a determinant of host range restriction. A panel of avian influenza viruses isolated between 1927 and 1997 was assembled. The selected viruses showed variation in their ability to activate the expression of a reporter gene under the control of the IFN-β promoter and in the levels of IFN induced in mammalian cells. Surprisingly, the avian NS1 proteins expressed alone or in the genetic background of a human influenza virus controlled IFN-β induction in a manner similar to the NS1 protein of human strains. There was no direct correlation between the IFN-β induction and replication of avian influenza viruses in human A549 cells. Nevertheless, human cells deficient in the type I IFN system showed enhanced replication of the avian viruses studied, implying that the human type I IFN response limits avian influenza viruses and can contribute to host range restriction.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="publisher-id">jvi</journal-id><journal-title>Journal of Virology</journal-title><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17182679</article-id><article-id pub-id-type="pmc">1865923</article-id><article-id pub-id-type="publisher-id">1856-06</article-id><article-id pub-id-type="doi">10.1128/JVI.01856-06</article-id><article-categories><subj-group subj-group-type="heading"><subject>Cellular Response to Infection</subject></subj-group></article-categories><title-group><article-title>NS1 Proteins of Avian Influenza A Viruses Can Act as Antagonists of the Human Alpha/Beta Interferon Response<xref ref-type="fn" rid="fn4">▿</xref> </article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hayman</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="fn1">†</xref></contrib><contrib contrib-type="author"><name><surname>Comely</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Lackenby</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref><xref ref-type="fn" rid="fn2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Hartgroves</surname><given-names>L. C. S.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Goodbourn</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>McCauley</surname><given-names>J. W.</given-names></name><xref ref-type="aff" rid="aff1">2</xref><xref ref-type="fn" rid="fn3">§</xref></contrib><contrib contrib-type="author"><name><surname>Barclay</surname><given-names>W. S.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff1">School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom,<label>1</label> Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN, United Kingdom,<label>2</label> Division of Basic Medical Sciences, St. George's, University of London, London SW17 0RE, United Kingdom<label>3</label></aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address: School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom. Phone: 44-1189-316671. Fax: 44-1189-316671. E-mail: <email>w.s.barclay@reading.ac.uk</email>.</p></fn><fn id="fn1"><label>†</label><p>Present address: Institute of Immunology, University of Oslo, Rikshospitalet-Radiumhospitalet Medical Centre, 0027 Oslo, Norway.</p></fn><fn id="fn2"><label>‡</label><p>Present address: Respiratory Virus Unit, Virus Reference Division, Centre for Infection, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom.</p></fn><fn id="fn3"><label>§</label><p>Present address: Division of Virology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom.</p></fn></author-notes><pub-date pub-type="ppub"><month>3</month><year>2007</year></pub-date><pub-date pub-type="epub"><day>20</day><month>12</month><year>2006</year></pub-date><volume>81</volume><issue>5</issue><fpage>2318</fpage><lpage>2327</lpage><history><date date-type="received"><day>25</day><month>8</month><year>2006</year></date><date date-type="accepted"><day>1</day><month>12</month><year>2006</year></date></history><copyright-statement>Copyright © 2007, American Society for Microbiology</copyright-statement><copyright-year>2007</copyright-year><self-uri xlink:title="pdf" xlink:href="zjv00507002318.pdf"></self-uri><abstract><p>Many viruses, including human influenza A virus, have developed strategies for counteracting the host type I interferon (IFN) response. We have explored whether avian influenza viruses were less capable of combating the type I IFN response in mammalian cells, as this might be a determinant of host range restriction. A panel of avian influenza viruses isolated between 1927 and 1997 was assembled. The selected viruses showed variation in their ability to activate the expression of a reporter gene under the control of the IFN-β promoter and in the levels of IFN induced in mammalian cells. Surprisingly, the avian NS1 proteins expressed alone or in the genetic background of a human influenza virus controlled IFN-β induction in a manner similar to the NS1 protein of human strains. There was no direct correlation between the IFN-β induction and replication of avian influenza viruses in human A549 cells. Nevertheless, human cells deficient in the type I IFN system showed enhanced replication of the avian viruses studied, implying that the human type I IFN response limits avian influenza viruses and can contribute to host range restriction.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Barclay, W S" sort="Barclay, W S" uniqKey="Barclay W" first="W. S." last="Barclay">W. S. Barclay</name><name sortKey="Comely, S" sort="Comely, S" uniqKey="Comely S" first="S." last="Comely">S. Comely</name><name sortKey="Goodbourn, S" sort="Goodbourn, S" uniqKey="Goodbourn S" first="S." last="Goodbourn">S. Goodbourn</name><name sortKey="Hartgroves, L C S" sort="Hartgroves, L C S" uniqKey="Hartgroves L" first="L. C. S." last="Hartgroves">L. C. S. Hartgroves</name><name sortKey="Hayman, A" sort="Hayman, A" uniqKey="Hayman A" first="A." last="Hayman">A. Hayman</name><name sortKey="Lackenby, A" sort="Lackenby, A" uniqKey="Lackenby A" first="A." last="Lackenby">A. Lackenby</name><name sortKey="Mccauley, J W" sort="Mccauley, J W" uniqKey="Mccauley J" first="J. W." last="Mccauley">J. W. Mccauley</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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