Genetic Evolution of Swine Influenza A (H3N2) Viruses in China from 1970 to 2006▿
Identifieur interne : 000B20 ( Pmc/Checkpoint ); précédent : 000B19; suivant : 000B21Genetic Evolution of Swine Influenza A (H3N2) Viruses in China from 1970 to 2006▿
Auteurs : Hai Yu ; Rong-Hong Hua ; Qiang Zhang ; Tian-Qiang Liu ; Hui-Li Liu ; Guo-Xin Li ; Guang-Zhi TongSource :
- Journal of Clinical Microbiology [ 0095-1137 ] ; 2008.
Abstract
Pigs are susceptible to both human and avian influenza viruses and have been proposed to be intermediate hosts, or mixing vessels, for the generation of pandemic influenza viruses through reassortment or adaptation to the mammalian host. In this study, we summarize and report for the first time the coexistence of wholly human-like H3N2 viruses, double-reassortant H3N2 viruses, and triple-reassortant H3N2 viruses in pigs in China by analyzing the eight genes of swine influenza A (H3N2) viruses found in China from 1970 to 2006. In 1970, the first wholly human-like H3N2 (Hong Kong/68-like) viruses were isolated from pigs in Taiwan, and then in the next years Victoria/75-like, Sydney/97-like, New York/99-like, and Moscow/99-like swine H3N2 viruses were regularly isolated in China. In the 1980s, two triple-reassortant viruses were isolated from pigs. Recently, the double-reassortant viruses containing genes from the human (HA and NA) and avian (PB2, PB1, PA, NP, M, and NS) lineages and the triple-reassortant viruses containing genes from the human (HA and NA), classical swine (NP), and avian (PB2, PB1, PA, M, and NS) lineages emerged in pigs in China. The coexistence of wholly human-like and reassortant viruses provides further evidence that pigs serve as intermediate hosts, or mixing vessels, and emphasizes the importance of reinforcing swine influenza virus surveillance in China.
Url:
DOI: 10.1128/JCM.01257-07
PubMed: 18199784
PubMed Central: 2268354
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic Evolution of Swine Influenza A (H3N2) Viruses in China from 1970 to 2006<xref ref-type="fn" rid="fn1">▿</xref> </title><author><name sortKey="Yu, Hai" sort="Yu, Hai" uniqKey="Yu H" first="Hai" last="Yu">Hai Yu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hua, Rong Hong" sort="Hua, Rong Hong" uniqKey="Hua R" first="Rong-Hong" last="Hua">Rong-Hong Hua</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Qiang" sort="Zhang, Qiang" uniqKey="Zhang Q" first="Qiang" last="Zhang">Qiang Zhang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Liu, Tian Qiang" sort="Liu, Tian Qiang" uniqKey="Liu T" first="Tian-Qiang" last="Liu">Tian-Qiang Liu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Liu, Hui Li" sort="Liu, Hui Li" uniqKey="Liu H" first="Hui-Li" last="Liu">Hui-Li Liu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Guo Xin" sort="Li, Guo Xin" uniqKey="Li G" first="Guo-Xin" last="Li">Guo-Xin Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tong, Guang Zhi" sort="Tong, Guang Zhi" uniqKey="Tong G" first="Guang-Zhi" last="Tong">Guang-Zhi Tong</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18199784</idno><idno type="pmc">2268354</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268354</idno><idno type="RBID">PMC:2268354</idno><idno type="doi">10.1128/JCM.01257-07</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000335</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000335</idno><idno type="wicri:Area/Pmc/Curation">000335</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000335</idno><idno type="wicri:Area/Pmc/Checkpoint">000B20</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B20</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic Evolution of Swine Influenza A (H3N2) Viruses in China from 1970 to 2006<xref ref-type="fn" rid="fn1">▿</xref> </title><author><name sortKey="Yu, Hai" sort="Yu, Hai" uniqKey="Yu H" first="Hai" last="Yu">Hai Yu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hua, Rong Hong" sort="Hua, Rong Hong" uniqKey="Hua R" first="Rong-Hong" last="Hua">Rong-Hong Hua</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Qiang" sort="Zhang, Qiang" uniqKey="Zhang Q" first="Qiang" last="Zhang">Qiang Zhang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Liu, Tian Qiang" sort="Liu, Tian Qiang" uniqKey="Liu T" first="Tian-Qiang" last="Liu">Tian-Qiang Liu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Liu, Hui Li" sort="Liu, Hui Li" uniqKey="Liu H" first="Hui-Li" last="Liu">Hui-Li Liu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Guo Xin" sort="Li, Guo Xin" uniqKey="Li G" first="Guo-Xin" last="Li">Guo-Xin Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tong, Guang Zhi" sort="Tong, Guang Zhi" uniqKey="Tong G" first="Guang-Zhi" last="Tong">Guang-Zhi Tong</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Microbiology</title><idno type="ISSN">0095-1137</idno><idno type="eISSN">1098-660X</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Pigs are susceptible to both human and avian influenza viruses and have been proposed to be intermediate hosts, or mixing vessels, for the generation of pandemic influenza viruses through reassortment or adaptation to the mammalian host. In this study, we summarize and report for the first time the coexistence of wholly human-like H3N2 viruses, double-reassortant H3N2 viruses, and triple-reassortant H3N2 viruses in pigs in China by analyzing the eight genes of swine influenza A (H3N2) viruses found in China from 1970 to 2006. In 1970, the first wholly human-like H3N2 (Hong Kong/68-like) viruses were isolated from pigs in Taiwan, and then in the next years Victoria/75-like, Sydney/97-like, New York/99-like, and Moscow/99-like swine H3N2 viruses were regularly isolated in China. In the 1980s, two triple-reassortant viruses were isolated from pigs. Recently, the double-reassortant viruses containing genes from the human (HA and NA) and avian (PB2, PB1, PA, NP, M, and NS) lineages and the triple-reassortant viruses containing genes from the human (HA and NA), classical swine (NP), and avian (PB2, PB1, PA, M, and NS) lineages emerged in pigs in China. The coexistence of wholly human-like and reassortant viruses provides further evidence that pigs serve as intermediate hosts, or mixing vessels, and emphasizes the importance of reinforcing swine influenza virus surveillance in China.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Microbiol</journal-id><journal-title>Journal of Clinical Microbiology</journal-title><issn pub-type="ppub">0095-1137</issn><issn pub-type="epub">1098-660X</issn><publisher><publisher-name>American Society for Microbiology (ASM)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18199784</article-id><article-id pub-id-type="pmc">2268354</article-id><article-id pub-id-type="publisher-id">1257-07</article-id><article-id pub-id-type="doi">10.1128/JCM.01257-07</article-id><article-categories><subj-group subj-group-type="heading"><subject>Virology</subject></subj-group></article-categories><title-group><article-title>Genetic Evolution of Swine Influenza A (H3N2) Viruses in China from 1970 to 2006<xref ref-type="fn" rid="fn1">▿</xref> </article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Hai</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hua</surname><given-names>Rong-Hong</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Qiang</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Tian-Qiang</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Hui-Li</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Guo-Xin</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tong</surname><given-names>Guang-Zhi</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff1">National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China,<label>1</label> Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200232, China,<label>2</label> Institute of Animal Sciences and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China<label>3</label></aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address: National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 427 Maduan Street, Harbin 150001, China. Phone and fax: (86) 451-82734181. E-mail: <email>gztong@hvri.ac.cn</email></p></fn></author-notes><pub-date pub-type="ppub"><month>3</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>16</day><month>1</month><year>2008</year></pub-date><volume>46</volume><issue>3</issue><fpage>1067</fpage><lpage>1075</lpage><history><date date-type="received"><day>22</day><month>6</month><year>2007</year></date><date date-type="rev-recd"><day>7</day><month>11</month><year>2007</year></date><date date-type="accepted"><day>27</day><month>12</month><year>2007</year></date></history><permissions><copyright-statement>Copyright © 2008, American Society for Microbiology</copyright-statement></permissions><self-uri xlink:title="pdf" xlink:href="zjm00308001067.pdf"></self-uri><abstract><p>Pigs are susceptible to both human and avian influenza viruses and have been proposed to be intermediate hosts, or mixing vessels, for the generation of pandemic influenza viruses through reassortment or adaptation to the mammalian host. In this study, we summarize and report for the first time the coexistence of wholly human-like H3N2 viruses, double-reassortant H3N2 viruses, and triple-reassortant H3N2 viruses in pigs in China by analyzing the eight genes of swine influenza A (H3N2) viruses found in China from 1970 to 2006. In 1970, the first wholly human-like H3N2 (Hong Kong/68-like) viruses were isolated from pigs in Taiwan, and then in the next years Victoria/75-like, Sydney/97-like, New York/99-like, and Moscow/99-like swine H3N2 viruses were regularly isolated in China. In the 1980s, two triple-reassortant viruses were isolated from pigs. Recently, the double-reassortant viruses containing genes from the human (HA and NA) and avian (PB2, PB1, PA, NP, M, and NS) lineages and the triple-reassortant viruses containing genes from the human (HA and NA), classical swine (NP), and avian (PB2, PB1, PA, M, and NS) lineages emerged in pigs in China. The coexistence of wholly human-like and reassortant viruses provides further evidence that pigs serve as intermediate hosts, or mixing vessels, and emphasizes the importance of reinforcing swine influenza virus surveillance in China.</p></abstract></article-meta></front><floats-wrap><fig position="float" id="f1"><label>FIG. 1.</label><caption><p>Phylogenetic tree of the HA (positions 98 to 1059) gene of the H3N2 swine influenza viruses in China from 1970 to 2006. The unrooted phylogenetic tree was generated by the distance-based neighbor-joining method using MEGA 3.1. The reliability of the tree was assessed by bootstrap analysis with 1,000 replications; only bootstrap values of >90% are shown. Different lineages and sublineages are indicated by different colors.</p></caption><graphic xlink:href="zjm0030879900001"></graphic></fig><fig position="float" id="f2"><label>FIG. 2.</label><caption><p>Phylogenetic trees of the NA (positions 746 to 1386) and PA (positions 1434 to 1580) genes of the H3N2 swine influenza viruses in China from 1970 to 2006. The method used is described in the legend to Fig. <xref rid="f1" ref-type="fig">1</xref>. Different lineages are indicated by different colors.</p></caption><graphic xlink:href="zjm0030879900002"></graphic></fig><fig position="float" id="f3"><label>FIG. 3.</label><caption><p>Phylogenetic trees of the NP (positions 747 to 1504) and M (positions 149 to 888) genes of the H3N2 swine influenza viruses in China from 1970 to 2006. The method used is described in the legend to Fig. <xref rid="f1" ref-type="fig">1</xref>. Different lineages are indicated by different colors.</p></caption><graphic xlink:href="zjm0030879900003"></graphic></fig><fig position="float" id="f4"><label>FIG. 4.</label><caption><p>Alignment of HA1 amino acid sequences of the swine H3N2 influenza viruses from 1970 to 2006. The underlined residues are antigenic sites (lowercase letters indicate discrete antigenic sites), residues in green are potential glycosylation sites, and residues in yellow shade denote the receptor-binding sites. Swine influenza viruses of different lineages are indicated by different colors, as shown in Fig. <xref rid="f1" ref-type="fig">1</xref>.</p></caption><graphic xlink:href="zjm003087990004a"></graphic><graphic xlink:href="zjm003087990004b"></graphic></fig><table-wrap position="float" id="t1"><label>TABLE 1.</label><caption><p>GenBank accession numbers and origins of gene segments of swine H3N2 influenza viruses isolated in China from 1970 to 2006<xref ref-type="table-fn" rid="t1fn1"><italic>a</italic></xref></p></caption><table frame="hsides" rules="groups"><thead><tr><th colspan="1" rowspan="2" align="center" valign="middle">Isolate</th><th colspan="8" rowspan="1" align="center" valign="bottom">Accession no. or origin of gene:
<hr></hr></th></tr><tr><th colspan="1" rowspan="1" align="center" valign="bottom">HA</th><th colspan="1" rowspan="1" align="center" valign="bottom">NA</th><th colspan="1" rowspan="1" align="center" valign="bottom">PB2</th><th colspan="1" rowspan="1" align="center" valign="bottom">PB1</th><th colspan="1" rowspan="1" align="center" valign="bottom">PA</th><th colspan="1" rowspan="1" align="center" valign="bottom">NP</th><th colspan="1" rowspan="1" align="center" valign="bottom">M</th><th colspan="1" rowspan="1" align="center" valign="bottom">NS</th></tr></thead><tbody><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Taiwan/7310/70</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AJ311454">AJ311454</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AJ311456">AJ311456</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">-<xref ref-type="table-fn" rid="t1fn4"><italic>d</italic></xref></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/1/76</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21174">D21174</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21187">D21187</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/3/76</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21175">D21175</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">D00715</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/6/76</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21176">D21176</ext-link></td><td colspan="1" rowspan="1" align="center" valign="top"></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="M22571">M22571</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/13/77</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21177">D21177</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21190">D21190</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/21/77</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21178">D21178</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21191">D21191</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/72/77</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21179">D21179</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21192">D21192</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/82/78</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21181">D21181</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21193">D21193</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/81/78</td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="M19057">M19057</ext-link></bold><xref ref-type="table-fn" rid="t1fn3"><italic>c</italic></xref></td><td colspan="1" rowspan="1" align="center" valign="top"></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="M26080">M26080</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/126/82</td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="M19056">M19056</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top">Human<xref ref-type="table-fn" rid="t1fn2"><italic>b</italic></xref></td><td colspan="1" rowspan="1" align="left" valign="top"><underline>Swine</underline><xref ref-type="table-fn" rid="t1fn2"><italic>b</italic></xref></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="M25927">M25927</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="M26081">M26081</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="M63771">M63771</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="M55477"><underline>M55477</underline></ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="M55483"><underline>M55483</underline></ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/127/82</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21182">D21182</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="D21194">D21194</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><underline>Swine</underline><xref ref-type="table-fn" rid="t1fn2"><italic>b</italic></xref></td><td colspan="1" rowspan="1" align="left" valign="top"><underline>Swine</underline><xref ref-type="table-fn" rid="t1fn2"><italic>b</italic></xref></td><td colspan="1" rowspan="1" align="left" valign="top"><underline>Swine</underline><xref ref-type="table-fn" rid="t1fn2"><italic>b</italic></xref></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="M22570"><underline>M22570</underline></ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="M63524">M63524</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><underline>Swine</underline><xref ref-type="table-fn" rid="t1fn2"><italic>b</italic></xref></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/2405/98</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400752">AF400752</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400759">AF400759</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400761">AF400761</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400764">AF400764</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400767">AF400767</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400755">AF400755</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400770">AF400770</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400773">AF400773</ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/2422/98</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400753">AF400753</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400758">AF400758</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400762">AF400762</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400765">AF400765</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400768">AF400768</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400756">AF400756</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400771">AF400771</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400774">AF400774</ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/2429/98</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400754">AF400754</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400760">AF400760</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400763">AF400763</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400766">AF400766</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400769">AF400769</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400757">AF400757</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400772">AF400772</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AF400775">AF400775</ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/4361/99</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363509">AY363509</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363545">AY363545</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363455">AY363455</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363473">AY363473</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363491">AY363491</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363527">AY363527</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363563">AY363563</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363581">AY363581</ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/q066/99</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363518">AY363518</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363554">AY363554</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363464">AY363464</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363482">AY363482</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363500">AY363500</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363536">AY363536</ext-link></td><td colspan="1" 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rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363484">AY363484</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363502">AY363502</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363538">AY363538</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363574">AY363574</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363592">AY363592</ext-link></bold></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/5212/99</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363521">AY363521</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363557">AY363557</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363467">AY363467</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363485">AY363485</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363503">AY363503</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363539">AY363539</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363575">AY363575</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363593">AY363593</ext-link></bold></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/7220/00</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363510">AY363510</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363546">AY363546</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363456">AY363456</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363474">AY363474</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363492">AY363492</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363528">AY363528</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363564">AY363564</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363582">AY363582</ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/312/00</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363511">AY363511</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363547">AY363547</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363457">AY363457</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363475">AY363475</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363493">AY363493</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363529">AY363529</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363565">AY363565</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363583">AY363583</ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/7982/00</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363522">AY363522</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363558">AY363558</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363468">AY363468</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363486">AY363486</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363504">AY363504</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363540">AY363540</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363576">AY363576</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363594">AY363594</ext-link></bold></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Heilongjiang/74/00</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="DQ021911">DQ021911</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/9285/01</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363512">AY363512</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363548">AY363548</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363458">AY363458</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363476">AY363476</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363494">AY363494</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363530">AY363530</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363566">AY363566</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363584">AY363584</ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/1311/01</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363513">AY363513</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363549">AY363549</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363459">AY363459</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363477">AY363477</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363495">AY363495</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363531">AY363531</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363567">AY363567</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363585">AY363585</ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/9840/01</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363514">AY363514</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363550">AY363550</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363460">AY363460</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363478">AY363478</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363496">AY363496</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363532">AY363532</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363568">AY363568</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363586">AY363586</ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/9296/01</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363523">AY363523</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY363559">AY363559</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363469">AY363469</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363487">AY363487</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363505">AY363505</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363541">AY363541</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363577">AY363577</ext-link></bold></td><td colspan="1" rowspan="1" align="left" valign="top"><bold><ext-link ext-link-type="gen" xlink:href="AY363595">AY363595</ext-link></bold></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Hong Kong/9745/01</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link 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valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Guangdong/3/03</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY852274">AY852274</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Guangdong/4/03</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY852275">AY852275</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Guangdong/5/03</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY852276">AY852276</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Guangdong/6/04</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="AY852277">AY852277</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td><td colspan="1" rowspan="1" align="left" valign="top">-</td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Heilongjiang/1/05</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273774">EU273774</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273782">EU273782</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273802">EU273802</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273798">EU273798</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273794">EU273794</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273786">EU273786</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273778">EU273778</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273790">EU273790</ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Guangdong/164/06</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273775">EU273775</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273783">EU273783</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273803">EU273803</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273799">EU273799</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273795">EU273795</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273787">EU273787</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273779">EU273779</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273791">EU273791</ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Guangdong/165/06</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273776">EU273776</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273784">EU273784</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273804">EU273804</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273800">EU273800</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273796">EU273796</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273788">EU273788</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273780">EU273780</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273792">EU273792</ext-link></td></tr><tr><td colspan="1" rowspan="1" align="left" valign="top">A/swine/Guangdong/166/06</td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273777">EU273777</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273785">EU273785</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273805">EU273805</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273801">EU273801</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273797">EU273797</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273789">EU273789</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273781">EU273781</ext-link></td><td colspan="1" rowspan="1" align="left" valign="top"><ext-link ext-link-type="gen" xlink:href="EU273793">EU273793</ext-link></td></tr></tbody></table><table-wrap-foot><fn id="t1fn1"><label>a</label><p>Partial sequences of each gene of our isolates, together with sequences from GenBank, were analyzed by the distance-based neighbor-joining method using phylogenetic analysis software (MEGA 3.1). Nucleotide sequences of HA (positions 98 to 1059), NA (positions 746 to 1386), PB2 (positions 1037 to 2219), PB1 (positions 950 to 2177), PA (positions 1434 to 1580), NP (positions 747 to 1504), M (positions 149 to 888), and NS (positions 27 to 864) genes were examined in this study. GenBank accession numbers in boldface indicate that the gene segments are of avian origin; underlined accession numbers denote that the gene segments are of swine origin; the rest of the genes are of human origin.</p></fn><fn id="t1fn2"><label>b</label><p>The origin of these genes was reported previously (<xref ref-type="bibr" rid="r29">29</xref>).</p></fn><fn id="t1fn3"><label>c</label><p>Sequence analysis indicates that this gene is equally closely related to the HA gene of human and duck H3 viruses and may come from either origin.</p></fn><fn id="t1fn4"><label>d</label><p>A dash indicates that the sequence was not available from GenBank.</p></fn></table-wrap-foot></table-wrap></floats-wrap></pmc><affiliations><list></list><tree><noCountry><name sortKey="Hua, Rong Hong" sort="Hua, Rong Hong" uniqKey="Hua R" first="Rong-Hong" last="Hua">Rong-Hong Hua</name><name sortKey="Li, Guo Xin" sort="Li, Guo Xin" uniqKey="Li G" first="Guo-Xin" last="Li">Guo-Xin Li</name><name sortKey="Liu, Hui Li" sort="Liu, Hui Li" uniqKey="Liu H" first="Hui-Li" last="Liu">Hui-Li Liu</name><name sortKey="Liu, Tian Qiang" sort="Liu, Tian Qiang" uniqKey="Liu T" first="Tian-Qiang" last="Liu">Tian-Qiang Liu</name><name sortKey="Tong, Guang Zhi" sort="Tong, Guang Zhi" uniqKey="Tong G" first="Guang-Zhi" last="Tong">Guang-Zhi Tong</name><name sortKey="Yu, Hai" sort="Yu, Hai" uniqKey="Yu H" first="Hai" last="Yu">Hai Yu</name><name sortKey="Zhang, Qiang" sort="Zhang, Qiang" uniqKey="Zhang Q" first="Qiang" last="Zhang">Qiang Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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