Acquired heterosubtypic antibodies in human immunity for avian H5N1 influenza
Identifieur interne : 000A86 ( Pmc/Checkpoint ); précédent : 000A85; suivant : 000A87Acquired heterosubtypic antibodies in human immunity for avian H5N1 influenza
Auteurs : Garry W. Lynch [Australie] ; Paul Selleck [Australie] ; John S. Sullivan [Australie]Source :
- Journal of Molecular and Genetic Medicine : An International Journal of Biomedical Research [ 1747-0862 ] ; 2009.
Abstract
Well understood are the adaptive and dramatic neutralizing homosubtypic antibody responses to hypervariable, immunodominant sites of the hemagglutinin (HA) and neuraminidase (NA) of individual influenza strains. These define influenza subtypes and vaccines modelled upon their HA and NA antigens provide seasonal neutralizing antibody protection against subsequent exposure to the strain and its close relatives, but give little if any protection against antigenically drifted or shifted strains. Contrasting to this is a different form of acquired antibody response, called heterosubtypic immunity. This provides a more seasoned adaptive antibody response to immune-recessive epitopes that are highly-conserved amongst strains. Although, such responses are of lower individual amplitudes than seasonal mechanisms they are active across influenza subtypes, and may give pre-emptive protection against new strains yet to emerge. Heterosubtypic immunities have been well studied in animals, but surprisingly there is minimal evidence for this type of antibody immunity in humans. Thus championed is the notion that seasoned humoral responses can through repeated exposure to sites widely conserved across different strains, cumulatively provide humans with a level of broad protection against emergent novel strains, such as H5N1, that is not afforded by seasonal humoral responses.
Url:
PubMed: 20076792
PubMed Central: 2805841
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Lynch</name><affiliation><nlm:aff id="aff1">Biosafety, Immunobiology, Global Health and Pandemic Infections Research, Central Clinical School, Faculties of Medicine</nlm:aff><wicri:noCountry code="subfield">Faculties of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Veterinary Science, The University of Sydney, Camperdown, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Veterinary Science, The University of Sydney, Camperdown, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Cellular and Molecular Pathology Research Unit, Oral Pathology and Oral Medicine, Westmead Centre for Oral Health, Westmead Hospital and Faculty of Dentistry, University of Sydney, Westmead, NSW 2145, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cellular and Molecular Pathology Research Unit, Oral Pathology and Oral Medicine, Westmead Centre for Oral Health, Westmead Hospital and Faculty of Dentistry, University of Sydney, Westmead, NSW 2145</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Selleck, Paul" sort="Selleck, Paul" uniqKey="Selleck P" first="Paul" last="Selleck">Paul Selleck</name><affiliation wicri:level="1"><nlm:aff id="aff4">The Australian Animal Health Laboratories, CSIRO, Geelong, Vic 3219, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The Australian Animal Health Laboratories, CSIRO, Geelong, Vic 3219</wicri:regionArea><wicri:noRegion>Vic 3219</wicri:noRegion></affiliation></author><author><name sortKey="Sullivan, John S" sort="Sullivan, John S" uniqKey="Sullivan J" first="John S" last="Sullivan">John S. 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Lynch</name><affiliation><nlm:aff id="aff1">Biosafety, Immunobiology, Global Health and Pandemic Infections Research, Central Clinical School, Faculties of Medicine</nlm:aff><wicri:noCountry code="subfield">Faculties of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Veterinary Science, The University of Sydney, Camperdown, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Veterinary Science, The University of Sydney, Camperdown, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Cellular and Molecular Pathology Research Unit, Oral Pathology and Oral Medicine, Westmead Centre for Oral Health, Westmead Hospital and Faculty of Dentistry, University of Sydney, Westmead, NSW 2145, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cellular and Molecular Pathology Research Unit, Oral Pathology and Oral Medicine, Westmead Centre for Oral Health, Westmead Hospital and Faculty of Dentistry, University of Sydney, Westmead, NSW 2145</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Selleck, Paul" sort="Selleck, Paul" uniqKey="Selleck P" first="Paul" last="Selleck">Paul Selleck</name><affiliation wicri:level="1"><nlm:aff id="aff4">The Australian Animal Health Laboratories, CSIRO, Geelong, Vic 3219, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The Australian Animal Health Laboratories, CSIRO, Geelong, Vic 3219</wicri:regionArea><wicri:noRegion>Vic 3219</wicri:noRegion></affiliation></author><author><name sortKey="Sullivan, John S" sort="Sullivan, John S" uniqKey="Sullivan J" first="John S" last="Sullivan">John S. Sullivan</name><affiliation><nlm:aff id="aff1">Biosafety, Immunobiology, Global Health and Pandemic Infections Research, Central Clinical School, Faculties of Medicine</nlm:aff><wicri:noCountry code="subfield">Faculties of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Children's Cancer Institute Australia for Medical Research, Randwick, NSW 2031, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Children's Cancer Institute Australia for Medical Research, Randwick, NSW 2031</wicri:regionArea><wicri:noRegion>NSW 2031</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Molecular and Genetic Medicine : An International Journal of Biomedical Research</title><idno type="eISSN">1747-0862</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Well understood are the adaptive and dramatic neutralizing homosubtypic antibody responses to hypervariable, immunodominant sites of the hemagglutinin (HA) and neuraminidase (NA) of individual influenza strains. These define influenza subtypes and vaccines modelled upon their HA and NA antigens provide seasonal neutralizing antibody protection against subsequent exposure to the strain and its close relatives, but give little if any protection against antigenically drifted or shifted strains. Contrasting to this is a different form of acquired antibody response, called heterosubtypic immunity. This provides a more seasoned adaptive antibody response to immune-recessive epitopes that are highly-conserved amongst strains. Although, such responses are of lower individual amplitudes than seasonal mechanisms they are active across influenza subtypes, and may give pre-emptive protection against new strains yet to emerge. Heterosubtypic immunities have been well studied in animals, but surprisingly there is minimal evidence for this type of antibody immunity in humans. Thus championed is the notion that seasoned humoral responses can through repeated exposure to sites widely conserved across different strains, cumulatively provide humans with a level of broad protection against emergent novel strains, such as H5N1, that is not afforded by seasonal humoral responses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bui, Hh" uniqKey="Bui H">HH Bui</name></author><author><name sortKey="Peters, B" uniqKey="Peters B">B Peters</name></author><author><name sortKey="Assarsson, E" uniqKey="Assarsson E">E Assarsson</name></author><author><name sortKey="Mbawuike, I" uniqKey="Mbawuike I">I Mbawuike</name></author><author><name sortKey="Sette, A" uniqKey="Sette A">A Sette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carragher, Dm" uniqKey="Carragher D">DM Carragher</name></author><author><name sortKey="Kaminski, Da" uniqKey="Kaminski D">DA 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Mol Genet Med</journal-id><journal-id journal-id-type="publisher-id">jmgm</journal-id><journal-title-group><journal-title>Journal of Molecular and Genetic Medicine : An International Journal of Biomedical Research</journal-title></journal-title-group><issn pub-type="epub">1747-0862</issn><publisher><publisher-name>Library Publishing Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20076792</article-id><article-id pub-id-type="pmc">2805841</article-id><article-categories><subj-group subj-group-type="heading"><subject>Minireview</subject></subj-group></article-categories><title-group><article-title>Acquired heterosubtypic antibodies in human immunity for avian H5N1 influenza</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lynch</surname><given-names>Garry W</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Selleck</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Sullivan</surname><given-names>John S</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><aff id="aff1"><label>1</label>Biosafety, Immunobiology, Global Health and Pandemic Infections Research, Central Clinical School, Faculties of Medicine</aff><aff id="aff2"><label>2</label>Veterinary Science, The University of Sydney, Camperdown, NSW 2006, Australia</aff><aff id="aff3"><label>3</label>Cellular and Molecular Pathology Research Unit, Oral Pathology and Oral Medicine, Westmead Centre for Oral Health, Westmead Hospital and Faculty of Dentistry, University of Sydney, Westmead, NSW 2145, Australia</aff><aff id="aff4"><label>4</label>The Australian Animal Health Laboratories, CSIRO, Geelong, Vic 3219, Australia</aff><aff id="aff5"><label>5</label>Children's Cancer Institute Australia for Medical Research, Randwick, NSW 2031, Australia</aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>Correspondance to: Garry Lynch, <email>garry_lynch@optusnet.com.au</email>, Tel: +61 2 9519 8151, Fax: +61 2 9519 8151</corresp></author-notes><pub-date pub-type="collection"><month>12</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2009</year></pub-date><volume>3</volume><issue>2</issue><fpage>205</fpage><lpage>209</lpage><history><date date-type="received"><day>31</day><month>8</month><year>2009</year></date><date date-type="rev-recd"><day>07</day><month>12</month><year>2009</year></date><date date-type="accepted"><day>09</day><month>12</month><year>2009</year></date></history><permissions><copyright-statement>© The Authors</copyright-statement><copyright-year>2009</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/2.0/uk/"><license-p>This is an open access article, published under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/2.0/uk/">http://creativecommons.org/licenses/by-nc/2.0/uk/</ext-link>). This license permits non-commercial use, distribution and reproduction of the article, provided the original work is appropriately acknowledged with correct citation details.</license-p></license></permissions><abstract><p>Well understood are the adaptive and dramatic neutralizing homosubtypic antibody responses to hypervariable, immunodominant sites of the hemagglutinin (HA) and neuraminidase (NA) of individual influenza strains. These define influenza subtypes and vaccines modelled upon their HA and NA antigens provide seasonal neutralizing antibody protection against subsequent exposure to the strain and its close relatives, but give little if any protection against antigenically drifted or shifted strains. Contrasting to this is a different form of acquired antibody response, called heterosubtypic immunity. This provides a more seasoned adaptive antibody response to immune-recessive epitopes that are highly-conserved amongst strains. Although, such responses are of lower individual amplitudes than seasonal mechanisms they are active across influenza subtypes, and may give pre-emptive protection against new strains yet to emerge. Heterosubtypic immunities have been well studied in animals, but surprisingly there is minimal evidence for this type of antibody immunity in humans. Thus championed is the notion that seasoned humoral responses can through repeated exposure to sites widely conserved across different strains, cumulatively provide humans with a level of broad protection against emergent novel strains, such as H5N1, that is not afforded by seasonal humoral responses.</p></abstract><kwd-group><kwd>Influenza</kwd><kwd>H5N1</kwd><kwd>H1N1</kwd><kwd>pandemic</kwd><kwd>immunity</kwd><kwd>heterosubtypic</kwd><kwd>antibody</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Australie</li></country><region><li>Nouvelle-Galles du Sud</li></region><settlement><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Lynch, Garry W" sort="Lynch, Garry W" uniqKey="Lynch G" first="Garry W" last="Lynch">Garry W. Lynch</name></region><name sortKey="Lynch, Garry W" sort="Lynch, Garry W" uniqKey="Lynch G" first="Garry W" last="Lynch">Garry W. Lynch</name><name sortKey="Selleck, Paul" sort="Selleck, Paul" uniqKey="Selleck P" first="Paul" last="Selleck">Paul Selleck</name><name sortKey="Sullivan, John S" sort="Sullivan, John S" uniqKey="Sullivan J" first="John S" last="Sullivan">John S. Sullivan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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