Molecular events leading to the creation of a pandemic influenza virus
Identifieur interne : 000A27 ( Pmc/Checkpoint ); précédent : 000A26; suivant : 000A28Molecular events leading to the creation of a pandemic influenza virus
Auteurs : Shipra Sharma [Inde] ; Adarsh Mayank [Inde] ; Sunil K. Lal [Inde]Source :
- Indian Journal of Microbiology [ 0046-8991 ] ; 2009.
Abstract
Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued to spread globally. This unique virus emerged from an avian, human, Eurasian swine viral strain and a North American swine strain belonging to the lineage of the 1930 swine virus. Till date H1N1/09 pandemic has been relatively mild and lacks the previously described molecular markers of influenza A pathogenicity and transmissibility. In this review, we will discuss the molecular and antigenic determinants of this virus and its designation as a low pathogenic strain, which carries the potential to develop into a devastating strain with subsequent mutations and reassortments.
Url:
DOI: 10.1007/s12088-009-0059-0
PubMed: 23100794
PubMed Central: 3450189
Affiliations:
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PMC:3450189Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued to spread globally. This unique virus emerged from an avian, human, Eurasian swine viral strain and a North American swine strain belonging to the lineage of the 1930 swine virus. Till date H1N1/09 pandemic has been relatively mild and lacks the previously described molecular markers of influenza A pathogenicity and transmissibility. In this review, we will discuss the molecular and antigenic determinants of this virus and its designation as a low pathogenic strain, which carries the potential to develop into a devastating strain with subsequent mutations and reassortments.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Indian J Microbiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Indian J. Microbiol</journal-id>
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<pub-date pub-type="epub"><day>7</day>
<month>1</month>
<year>2010</year>
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<pub-date pub-type="ppub"><month>12</month>
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<volume>49</volume>
<issue>4</issue>
<fpage>332</fpage>
<lpage>338</lpage>
<history><date date-type="received"><day>4</day>
<month>11</month>
<year>2009</year>
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<date date-type="accepted"><day>9</day>
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<permissions><copyright-statement>© Association of Microbiologists of India 2009</copyright-statement>
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<abstract id="Abs1"><p>Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued to spread globally. This unique virus emerged from an avian, human, Eurasian swine viral strain and a North American swine strain belonging to the lineage of the 1930 swine virus. Till date H1N1/09 pandemic has been relatively mild and lacks the previously described molecular markers of influenza A pathogenicity and transmissibility. In this review, we will discuss the molecular and antigenic determinants of this virus and its designation as a low pathogenic strain, which carries the potential to develop into a devastating strain with subsequent mutations and reassortments.</p>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>H1N1</kwd>
<kwd>Pandemic</kwd>
<kwd>Antigenic determinants</kwd>
<kwd>Pathogenicity</kwd>
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