Molecular events leading to the creation of a pandemic influenza virus
Identifieur interne : 000A27 ( Pmc/Checkpoint ); précédent : 000A26; suivant : 000A28Molecular events leading to the creation of a pandemic influenza virus
Auteurs : Shipra Sharma [Inde] ; Adarsh Mayank [Inde] ; Sunil K. Lal [Inde]Source :
- Indian Journal of Microbiology [ 0046-8991 ] ; 2009.
Abstract
Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued to spread globally. This unique virus emerged from an avian, human, Eurasian swine viral strain and a North American swine strain belonging to the lineage of the 1930 swine virus. Till date H1N1/09 pandemic has been relatively mild and lacks the previously described molecular markers of influenza A pathogenicity and transmissibility. In this review, we will discuss the molecular and antigenic determinants of this virus and its designation as a low pathogenic strain, which carries the potential to develop into a devastating strain with subsequent mutations and reassortments.
Url:
DOI: 10.1007/s12088-009-0059-0
PubMed: 23100794
PubMed Central: 3450189
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O. Box. 10504, ICGEB, Aruna Asaf Ali Road, New Delhi, 110067 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>P. O. Box. 10504, ICGEB, Aruna Asaf Ali Road, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Mayank, Adarsh" sort="Mayank, Adarsh" uniqKey="Mayank A" first="Adarsh" last="Mayank">Adarsh Mayank</name><affiliation wicri:level="1"><nlm:aff id="Aff1">P. O. Box. 10504, ICGEB, Aruna Asaf Ali Road, New Delhi, 110067 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>P. O. Box. 10504, ICGEB, Aruna Asaf Ali Road, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K." last="Lal">Sunil K. Lal</name><affiliation wicri:level="1"><nlm:aff id="Aff1">P. O. Box. 10504, ICGEB, Aruna Asaf Ali Road, New Delhi, 110067 India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>P. O. Box. 10504, ICGEB, Aruna Asaf Ali Road, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author></analytic><series><title level="j">Indian Journal of Microbiology</title><idno type="ISSN">0046-8991</idno><idno type="eISSN">0973-7715</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued to spread globally. This unique virus emerged from an avian, human, Eurasian swine viral strain and a North American swine strain belonging to the lineage of the 1930 swine virus. Till date H1N1/09 pandemic has been relatively mild and lacks the previously described molecular markers of influenza A pathogenicity and transmissibility. In this review, we will discuss the molecular and antigenic determinants of this virus and its designation as a low pathogenic strain, which carries the potential to develop into a devastating strain with subsequent mutations and reassortments.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Indian J Microbiol</journal-id><journal-id journal-id-type="iso-abbrev">Indian J. Microbiol</journal-id><journal-title-group><journal-title>Indian Journal of Microbiology</journal-title></journal-title-group><issn pub-type="ppub">0046-8991</issn><issn pub-type="epub">0973-7715</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23100794</article-id><article-id pub-id-type="pmc">3450189</article-id><article-id pub-id-type="publisher-id">59</article-id><article-id pub-id-type="doi">10.1007/s12088-009-0059-0</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Molecular events leading to the creation of a pandemic influenza virus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sharma</surname><given-names>Shipra</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Mayank</surname><given-names>Adarsh</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Lal</surname><given-names>Sunil K.</given-names></name><address><email>sunillal@icgeb.res.in</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1">P. O. Box. 10504, ICGEB, Aruna Asaf Ali Road, New Delhi, 110067 India</aff></contrib-group><pub-date pub-type="epub"><day>7</day><month>1</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2009</year></pub-date><volume>49</volume><issue>4</issue><fpage>332</fpage><lpage>338</lpage><history><date date-type="received"><day>4</day><month>11</month><year>2009</year></date><date date-type="accepted"><day>9</day><month>11</month><year>2009</year></date></history><permissions><copyright-statement>© Association of Microbiologists of India 2009</copyright-statement></permissions><abstract id="Abs1"><p>Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued to spread globally. This unique virus emerged from an avian, human, Eurasian swine viral strain and a North American swine strain belonging to the lineage of the 1930 swine virus. Till date H1N1/09 pandemic has been relatively mild and lacks the previously described molecular markers of influenza A pathogenicity and transmissibility. In this review, we will discuss the molecular and antigenic determinants of this virus and its designation as a low pathogenic strain, which carries the potential to develop into a devastating strain with subsequent mutations and reassortments.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>H1N1</kwd><kwd>Pandemic</kwd><kwd>Antigenic determinants</kwd><kwd>Pathogenicity</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Association of Microbiologists of India 2009</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Sharma, Shipra" sort="Sharma, Shipra" uniqKey="Sharma S" first="Shipra" last="Sharma">Shipra Sharma</name></noRegion><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K." last="Lal">Sunil K. Lal</name><name sortKey="Mayank, Adarsh" sort="Mayank, Adarsh" uniqKey="Mayank A" first="Adarsh" last="Mayank">Adarsh Mayank</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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