Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City
Identifieur interne : 000A15 ( Pmc/Checkpoint ); précédent : 000A14; suivant : 000A16Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City
Auteurs : Lourdes Garcia-Garcia [Mexique] ; Jose Luis Valdespino-G Mez [Mexique] ; Eduardo Lazcano-Ponce [Mexique] ; Aida Jimenez-Corona [Mexique] ; Anjarath Higuera-Iglesias [Mexique] ; Pablo Cruz-Hervert [Mexique] ; Bulmaro Cano-Arellano [Mexique] ; Antonio Garcia-Anaya [Mexique] ; Elizabeth Ferreira-Guerrero [Mexique] ; Renata Baez-Salda A [Mexique] ; Leticia Ferreyra-Reyes [Mexique] ; Samuel Ponce-De-Le N-Rosales [Mexique] ; Celia Alpuche-Aranda [Mexique] ; Mario Henry Rodriguez-L Pez [Mexique] ; Rogelio Perez-Padilla [Mexique] ; Mauricio Hernandez-Avila [Mexique]Source :
- The BMJ [ 0959-8138 ] ; 2009.
Abstract
Url:
DOI: 10.1136/bmj.b3928
PubMed: 19808768
PubMed Central: 2758337
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City</title><author><name sortKey="Garcia Garcia, Lourdes" sort="Garcia Garcia, Lourdes" uniqKey="Garcia Garcia L" first="Lourdes" last="Garcia-Garcia">Lourdes Garcia-Garcia</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Valdespino G Mez, Jose Luis" sort="Valdespino G Mez, Jose Luis" uniqKey="Valdespino G Mez J" first="Jose Luis" last="Valdespino-G Mez">Jose Luis Valdespino-G Mez</name><affiliation wicri:level="1"><nlm:aff id="aff2">Laboratorios de Biológicos y Reactivos de México (BIRMEX), Amores 1240, Col Del Valle, Delegación Benito Juárez. CP 03100, Distrito Federal, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorios de Biológicos y Reactivos de México (BIRMEX), Amores 1240, Col Del Valle, Delegación Benito Juárez. CP 03100, Distrito Federal</wicri:regionArea><wicri:noRegion>Distrito Federal</wicri:noRegion></affiliation></author><author><name sortKey="Lazcano Ponce, Eduardo" sort="Lazcano Ponce, Eduardo" uniqKey="Lazcano Ponce E" first="Eduardo" last="Lazcano-Ponce">Eduardo Lazcano-Ponce</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Jimenez Corona, Aida" sort="Jimenez Corona, Aida" uniqKey="Jimenez Corona A" first="Aida" last="Jimenez-Corona">Aida Jimenez-Corona</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Higuera Iglesias, Anjarath" sort="Higuera Iglesias, Anjarath" uniqKey="Higuera Iglesias A" first="Anjarath" last="Higuera-Iglesias">Anjarath Higuera-Iglesias</name><affiliation wicri:level="1"><nlm:aff id="aff3">Instituto Nacional de Enfermedades Respiratorias (INER), Distrito Federal, México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Instituto Nacional de Enfermedades Respiratorias (INER), Distrito Federal</wicri:regionArea><wicri:noRegion>Distrito Federal</wicri:noRegion></affiliation></author><author><name sortKey="Cruz Hervert, Pablo" sort="Cruz Hervert, Pablo" uniqKey="Cruz Hervert P" first="Pablo" last="Cruz-Hervert">Pablo Cruz-Hervert</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Cano Arellano, Bulmaro" sort="Cano Arellano, Bulmaro" uniqKey="Cano Arellano B" first="Bulmaro" last="Cano-Arellano">Bulmaro Cano-Arellano</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Garcia Anaya, Antonio" sort="Garcia Anaya, Antonio" uniqKey="Garcia Anaya A" first="Antonio" last="Garcia-Anaya">Antonio Garcia-Anaya</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Ferreira Guerrero, Elizabeth" sort="Ferreira Guerrero, Elizabeth" uniqKey="Ferreira Guerrero E" first="Elizabeth" last="Ferreira-Guerrero">Elizabeth Ferreira-Guerrero</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Baez Salda A, Renata" sort="Baez Salda A, Renata" uniqKey="Baez Salda A R" first="Renata" last="Baez-Salda A">Renata Baez-Salda A</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Ferreyra Reyes, Leticia" sort="Ferreyra Reyes, Leticia" uniqKey="Ferreyra Reyes L" first="Leticia" last="Ferreyra-Reyes">Leticia Ferreyra-Reyes</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Ponce De Le N Rosales, Samuel" sort="Ponce De Le N Rosales, Samuel" uniqKey="Ponce De Le N Rosales S" first="Samuel" last="Ponce-De-Le N-Rosales">Samuel Ponce-De-Le N-Rosales</name><affiliation wicri:level="1"><nlm:aff id="aff2">Laboratorios de Biológicos y Reactivos de México (BIRMEX), Amores 1240, Col Del Valle, Delegación Benito Juárez. CP 03100, Distrito Federal, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorios de Biológicos y Reactivos de México (BIRMEX), Amores 1240, Col Del Valle, Delegación Benito Juárez. CP 03100, Distrito Federal</wicri:regionArea><wicri:noRegion>Distrito Federal</wicri:noRegion></affiliation></author><author><name sortKey="Alpuche Aranda, Celia" sort="Alpuche Aranda, Celia" uniqKey="Alpuche Aranda C" first="Celia" last="Alpuche-Aranda">Celia Alpuche-Aranda</name><affiliation wicri:level="1"><nlm:aff id="aff4">Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE), Distrito Federal, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE), Distrito Federal</wicri:regionArea><wicri:noRegion>Distrito Federal</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez L Pez, Mario Henry" sort="Rodriguez L Pez, Mario Henry" uniqKey="Rodriguez L Pez M" first="Mario Henry" last="Rodriguez-L Pez">Mario Henry Rodriguez-L Pez</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Perez Padilla, Rogelio" sort="Perez Padilla, Rogelio" uniqKey="Perez Padilla R" first="Rogelio" last="Perez-Padilla">Rogelio Perez-Padilla</name><affiliation wicri:level="1"><nlm:aff id="aff3">Instituto Nacional de Enfermedades Respiratorias (INER), Distrito Federal, México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Instituto Nacional de Enfermedades Respiratorias (INER), Distrito Federal</wicri:regionArea><wicri:noRegion>Distrito Federal</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez Avila, Mauricio" sort="Hernandez Avila, Mauricio" uniqKey="Hernandez Avila M" first="Mauricio" last="Hernandez-Avila">Mauricio Hernandez-Avila</name><affiliation wicri:level="1"><nlm:aff id="aff5">Subsecretariat of Health Prevention and Promotion, Distrito Federal, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Subsecretariat of Health Prevention and Promotion, Distrito Federal</wicri:regionArea><wicri:noRegion>Distrito Federal</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19808768</idno><idno type="pmc">2758337</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758337</idno><idno type="RBID">PMC:2758337</idno><idno type="doi">10.1136/bmj.b3928</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000062</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000062</idno><idno type="wicri:Area/Pmc/Curation">000062</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000062</idno><idno type="wicri:Area/Pmc/Checkpoint">000A15</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City</title><author><name sortKey="Garcia Garcia, Lourdes" sort="Garcia Garcia, Lourdes" uniqKey="Garcia Garcia L" first="Lourdes" last="Garcia-Garcia">Lourdes Garcia-Garcia</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Valdespino G Mez, Jose Luis" sort="Valdespino G Mez, Jose Luis" uniqKey="Valdespino G Mez J" first="Jose Luis" last="Valdespino-G Mez">Jose Luis Valdespino-G Mez</name><affiliation wicri:level="1"><nlm:aff id="aff2">Laboratorios de Biológicos y Reactivos de México (BIRMEX), Amores 1240, Col Del Valle, Delegación Benito Juárez. CP 03100, Distrito Federal, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorios de Biológicos y Reactivos de México (BIRMEX), Amores 1240, Col Del Valle, Delegación Benito Juárez. CP 03100, Distrito Federal</wicri:regionArea><wicri:noRegion>Distrito Federal</wicri:noRegion></affiliation></author><author><name sortKey="Lazcano Ponce, Eduardo" sort="Lazcano Ponce, Eduardo" uniqKey="Lazcano Ponce E" first="Eduardo" last="Lazcano-Ponce">Eduardo Lazcano-Ponce</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Jimenez Corona, Aida" sort="Jimenez Corona, Aida" uniqKey="Jimenez Corona A" first="Aida" last="Jimenez-Corona">Aida Jimenez-Corona</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Higuera Iglesias, Anjarath" sort="Higuera Iglesias, Anjarath" uniqKey="Higuera Iglesias A" first="Anjarath" last="Higuera-Iglesias">Anjarath Higuera-Iglesias</name><affiliation wicri:level="1"><nlm:aff id="aff3">Instituto Nacional de Enfermedades Respiratorias (INER), Distrito Federal, México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Instituto Nacional de Enfermedades Respiratorias (INER), Distrito Federal</wicri:regionArea><wicri:noRegion>Distrito Federal</wicri:noRegion></affiliation></author><author><name sortKey="Cruz Hervert, Pablo" sort="Cruz Hervert, Pablo" uniqKey="Cruz Hervert P" first="Pablo" last="Cruz-Hervert">Pablo Cruz-Hervert</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Cano Arellano, Bulmaro" sort="Cano Arellano, Bulmaro" uniqKey="Cano Arellano B" first="Bulmaro" last="Cano-Arellano">Bulmaro Cano-Arellano</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Garcia Anaya, Antonio" sort="Garcia Anaya, Antonio" uniqKey="Garcia Anaya A" first="Antonio" last="Garcia-Anaya">Antonio Garcia-Anaya</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Ferreira Guerrero, Elizabeth" sort="Ferreira Guerrero, Elizabeth" uniqKey="Ferreira Guerrero E" first="Elizabeth" last="Ferreira-Guerrero">Elizabeth Ferreira-Guerrero</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Baez Salda A, Renata" sort="Baez Salda A, Renata" uniqKey="Baez Salda A R" first="Renata" last="Baez-Salda A">Renata Baez-Salda A</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Ferreyra Reyes, Leticia" sort="Ferreyra Reyes, Leticia" uniqKey="Ferreyra Reyes L" first="Leticia" last="Ferreyra-Reyes">Leticia Ferreyra-Reyes</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Ponce De Le N Rosales, Samuel" sort="Ponce De Le N Rosales, Samuel" uniqKey="Ponce De Le N Rosales S" first="Samuel" last="Ponce-De-Le N-Rosales">Samuel Ponce-De-Le N-Rosales</name><affiliation wicri:level="1"><nlm:aff id="aff2">Laboratorios de Biológicos y Reactivos de México (BIRMEX), Amores 1240, Col Del Valle, Delegación Benito Juárez. CP 03100, Distrito Federal, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorios de Biológicos y Reactivos de México (BIRMEX), Amores 1240, Col Del Valle, Delegación Benito Juárez. CP 03100, Distrito Federal</wicri:regionArea><wicri:noRegion>Distrito Federal</wicri:noRegion></affiliation></author><author><name sortKey="Alpuche Aranda, Celia" sort="Alpuche Aranda, Celia" uniqKey="Alpuche Aranda C" first="Celia" last="Alpuche-Aranda">Celia Alpuche-Aranda</name><affiliation wicri:level="1"><nlm:aff id="aff4">Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE), Distrito Federal, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE), Distrito Federal</wicri:regionArea><wicri:noRegion>Distrito Federal</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez L Pez, Mario Henry" sort="Rodriguez L Pez, Mario Henry" uniqKey="Rodriguez L Pez M" first="Mario Henry" last="Rodriguez-L Pez">Mario Henry Rodriguez-L Pez</name><affiliation wicri:level="1"><nlm:aff id="aff1">Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Salud Pública, Cuernavaca, Mor</wicri:regionArea><wicri:noRegion>Mor</wicri:noRegion></affiliation></author><author><name sortKey="Perez Padilla, Rogelio" sort="Perez Padilla, Rogelio" uniqKey="Perez Padilla R" first="Rogelio" last="Perez-Padilla">Rogelio Perez-Padilla</name><affiliation wicri:level="1"><nlm:aff id="aff3">Instituto Nacional de Enfermedades Respiratorias (INER), Distrito Federal, México</nlm:aff><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Instituto Nacional de Enfermedades Respiratorias (INER), Distrito Federal</wicri:regionArea><wicri:noRegion>Distrito Federal</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez Avila, Mauricio" sort="Hernandez Avila, Mauricio" uniqKey="Hernandez Avila M" first="Mauricio" last="Hernandez-Avila">Mauricio Hernandez-Avila</name><affiliation wicri:level="1"><nlm:aff id="aff5">Subsecretariat of Health Prevention and Promotion, Distrito Federal, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Subsecretariat of Health Prevention and Promotion, Distrito Federal</wicri:regionArea><wicri:noRegion>Distrito Federal</wicri:noRegion></affiliation></author></analytic><series><title level="j">The BMJ</title><idno type="ISSN">0959-8138</idno><idno type="eISSN">1756-1833</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Objective</bold> To evaluate the association of 2008-9 seasonal trivalent inactivated vaccine with cases of influenza A/H1N1 during the epidemic in Mexico.</p><p><bold>Design</bold> Frequency matched case-control study.</p><p><bold>Setting</bold> Specialty hospital in Mexico City, March to May 2009.</p><p><bold>Participants</bold> 60 patients with laboratory confirmed influenza A/H1N1 and 180 controls with other diseases (not influenza-like illness or pneumonia) living in Mexico City or the State of Mexico and matched for age and socioeconomic status.</p><p><bold>Main outcome measures</bold> Odds ratio and effectiveness of trivalent inactivated vaccine against influenza A/H1N1.</p><p><bold>Results</bold> Cases were more likely than controls to be admitted to hospital, undergo invasive mechanical ventilation, and die. Controls were more likely than cases to have chronic conditions that conferred a higher risk of influenza related complications. In the multivariate model, influenza A/H1N1 was independently associated with trivalent inactivated vaccine (odds ratio 0.27, 95% confidence interval 0.11 to 0.66) and underlying conditions (0.15, 0.08 to 0.30). Vaccine effectiveness was 73% (95% confidence interval 34% to 89%). None of the eight vaccinated cases died.</p><p><bold>Conclusions</bold> Preliminary evidence suggests some protection from the 2008-9 trivalent inactivated vaccine against pandemic influenza A/H1N1 2009, particularly severe forms of the disease, diagnosed in a specialty hospital during the influenza epidemic in Mexico City. </p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMJ</journal-id><journal-id journal-id-type="iso-abbrev">BMJ</journal-id><journal-id journal-id-type="publisher-id">bmj</journal-id><journal-title-group><journal-title>The BMJ</journal-title></journal-title-group><issn pub-type="ppub">0959-8138</issn><issn pub-type="epub">1756-1833</issn><publisher><publisher-name>BMJ Publishing Group Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19808768</article-id><article-id pub-id-type="pmc">2758337</article-id><article-id pub-id-type="publisher-id">garl693127</article-id><article-id pub-id-type="doi">10.1136/bmj.b3928</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group><subj-group subj-group-type="hw-coll-titles"><subject>Infectious Diseases</subject><subject>Epidemiologic Studies</subject><subject>Mechanical Ventilation</subject><subject>Mechanical Ventilation</subject><subject>Pneumonia (Respiratory Medicine)</subject></subj-group></article-categories><title-group><article-title>Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Garcia-Garcia</surname><given-names>Lourdes</given-names></name><role>research professor</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Valdespino-Gómez</surname><given-names>Jose Luis</given-names></name><role>epidemiologist</role><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lazcano-Ponce</surname><given-names>Eduardo</given-names></name><role>research professor</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jimenez-Corona</surname><given-names>Aida</given-names></name><role>research professor</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Higuera-Iglesias</surname><given-names>Anjarath</given-names></name><role>epidemiologist</role><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Cruz-Hervert</surname><given-names>Pablo</given-names></name><role>research professor</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Cano-Arellano</surname><given-names>Bulmaro</given-names></name><role>engineer</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Garcia-Anaya</surname><given-names>Antonio</given-names></name><role>engineer</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ferreira-Guerrero</surname><given-names>Elizabeth</given-names></name><role>epidemiologist</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Baez-Saldaña</surname><given-names>Renata</given-names></name><role>research professor</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ferreyra-Reyes</surname><given-names>Leticia</given-names></name><role>research professor</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ponce-de-León-Rosales</surname><given-names>Samuel</given-names></name><role>infectious diseases specialist</role><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Alpuche-Aranda</surname><given-names>Celia</given-names></name><role>infectious diseases specialist</role><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Rodriguez-López</surname><given-names>Mario Henry</given-names></name><role>research professor</role><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Perez-Padilla</surname><given-names>Rogelio</given-names></name><role>research professor</role><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hernandez-Avila</surname><given-names>Mauricio</given-names></name><role>epidemiologist</role><xref ref-type="aff" rid="aff5">5</xref></contrib><aff id="aff1"><label>1</label>Instituto Nacional de Salud Pública, Cuernavaca, Mor, Mexico</aff><aff id="aff2"><label>2</label>Laboratorios de Biológicos y Reactivos de México (BIRMEX), Amores 1240, Col Del Valle, Delegación Benito Juárez. CP 03100, Distrito Federal, Mexico</aff><aff id="aff3"><label>3</label>Instituto Nacional de Enfermedades Respiratorias (INER), Distrito Federal, México</aff><aff id="aff4"><label>4</label>Instituto de Diagnóstico y Referencia Epidemiológicos (InDRE), Distrito Federal, Mexico</aff><aff id="aff5"><label>5</label>Subsecretariat of Health Prevention and Promotion, Distrito Federal, Mexico</aff></contrib-group><author-notes><corresp>Correspondence to: J L Valdespino <email>jvaldespinog@birmex.gob.mx</email></corresp></author-notes><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>06</day><month>10</month><year>2009</year></pub-date><volume>339</volume><elocation-id>b3928</elocation-id><history><date date-type="accepted"><day>18</day><month>9</month><year>2009</year></date></history><permissions><license license-type="open-access"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/2.0/">http://creativecommons.org/licenses/by-nc/2.0/</ext-link> and <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/2.0/legalcode">http://creativecommons.org/licenses/by-nc/2.0/legalcode</ext-link>.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="bmj.b3928_default.pdf"></self-uri><abstract><p><bold>Objective</bold> To evaluate the association of 2008-9 seasonal trivalent inactivated vaccine with cases of influenza A/H1N1 during the epidemic in Mexico.</p><p><bold>Design</bold> Frequency matched case-control study.</p><p><bold>Setting</bold> Specialty hospital in Mexico City, March to May 2009.</p><p><bold>Participants</bold> 60 patients with laboratory confirmed influenza A/H1N1 and 180 controls with other diseases (not influenza-like illness or pneumonia) living in Mexico City or the State of Mexico and matched for age and socioeconomic status.</p><p><bold>Main outcome measures</bold> Odds ratio and effectiveness of trivalent inactivated vaccine against influenza A/H1N1.</p><p><bold>Results</bold> Cases were more likely than controls to be admitted to hospital, undergo invasive mechanical ventilation, and die. Controls were more likely than cases to have chronic conditions that conferred a higher risk of influenza related complications. In the multivariate model, influenza A/H1N1 was independently associated with trivalent inactivated vaccine (odds ratio 0.27, 95% confidence interval 0.11 to 0.66) and underlying conditions (0.15, 0.08 to 0.30). Vaccine effectiveness was 73% (95% confidence interval 34% to 89%). None of the eight vaccinated cases died.</p><p><bold>Conclusions</bold> Preliminary evidence suggests some protection from the 2008-9 trivalent inactivated vaccine against pandemic influenza A/H1N1 2009, particularly severe forms of the disease, diagnosed in a specialty hospital during the influenza epidemic in Mexico City. </p></abstract></article-meta></front></pmc><affiliations><list><country><li>Mexique</li></country></list><tree><country name="Mexique"><noRegion><name sortKey="Garcia Garcia, Lourdes" sort="Garcia Garcia, Lourdes" uniqKey="Garcia Garcia L" first="Lourdes" last="Garcia-Garcia">Lourdes Garcia-Garcia</name></noRegion><name sortKey="Alpuche Aranda, Celia" sort="Alpuche Aranda, Celia" uniqKey="Alpuche Aranda C" first="Celia" last="Alpuche-Aranda">Celia Alpuche-Aranda</name><name sortKey="Baez Salda A, Renata" sort="Baez Salda A, Renata" uniqKey="Baez Salda A R" first="Renata" last="Baez-Salda A">Renata Baez-Salda A</name><name sortKey="Cano Arellano, Bulmaro" sort="Cano Arellano, Bulmaro" uniqKey="Cano Arellano B" first="Bulmaro" last="Cano-Arellano">Bulmaro Cano-Arellano</name><name sortKey="Cruz Hervert, Pablo" sort="Cruz Hervert, Pablo" uniqKey="Cruz Hervert P" first="Pablo" last="Cruz-Hervert">Pablo Cruz-Hervert</name><name sortKey="Ferreira Guerrero, Elizabeth" sort="Ferreira Guerrero, Elizabeth" uniqKey="Ferreira Guerrero E" first="Elizabeth" last="Ferreira-Guerrero">Elizabeth Ferreira-Guerrero</name><name sortKey="Ferreyra Reyes, Leticia" sort="Ferreyra Reyes, Leticia" uniqKey="Ferreyra Reyes L" first="Leticia" last="Ferreyra-Reyes">Leticia Ferreyra-Reyes</name><name sortKey="Garcia Anaya, Antonio" sort="Garcia Anaya, Antonio" uniqKey="Garcia Anaya A" first="Antonio" last="Garcia-Anaya">Antonio Garcia-Anaya</name><name sortKey="Hernandez Avila, Mauricio" sort="Hernandez Avila, Mauricio" uniqKey="Hernandez Avila M" first="Mauricio" last="Hernandez-Avila">Mauricio Hernandez-Avila</name><name sortKey="Higuera Iglesias, Anjarath" sort="Higuera Iglesias, Anjarath" uniqKey="Higuera Iglesias A" first="Anjarath" last="Higuera-Iglesias">Anjarath Higuera-Iglesias</name><name sortKey="Jimenez Corona, Aida" sort="Jimenez Corona, Aida" uniqKey="Jimenez Corona A" first="Aida" last="Jimenez-Corona">Aida Jimenez-Corona</name><name sortKey="Lazcano Ponce, Eduardo" sort="Lazcano Ponce, Eduardo" uniqKey="Lazcano Ponce E" first="Eduardo" last="Lazcano-Ponce">Eduardo Lazcano-Ponce</name><name sortKey="Perez Padilla, Rogelio" sort="Perez Padilla, Rogelio" uniqKey="Perez Padilla R" first="Rogelio" last="Perez-Padilla">Rogelio Perez-Padilla</name><name sortKey="Ponce De Le N Rosales, Samuel" sort="Ponce De Le N Rosales, Samuel" uniqKey="Ponce De Le N Rosales S" first="Samuel" last="Ponce-De-Le N-Rosales">Samuel Ponce-De-Le N-Rosales</name><name sortKey="Rodriguez L Pez, Mario Henry" sort="Rodriguez L Pez, Mario Henry" uniqKey="Rodriguez L Pez M" first="Mario Henry" last="Rodriguez-L Pez">Mario Henry Rodriguez-L Pez</name><name sortKey="Valdespino G Mez, Jose Luis" sort="Valdespino G Mez, Jose Luis" uniqKey="Valdespino G Mez J" first="Jose Luis" last="Valdespino-G Mez">Jose Luis Valdespino-G Mez</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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