Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus
Identifieur interne : 000940 ( Pmc/Checkpoint ); précédent : 000939; suivant : 000941Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus
Auteurs : Jeff Alexander [États-Unis] ; Pamuk Bilsel [États-Unis] ; Marie-France Del Guercio [États-Unis] ; Aleksandra Marinkovic-Petrovic [États-Unis] ; Scott Southwood [États-Unis] ; Stephani Stewart [États-Unis] ; Glenn Ishioka [États-Unis] ; Maya F. Kotturi ; Jason Botten [États-Unis] ; John Sidney ; Mark Newman [États-Unis] ; Alessandro SetteSource :
- Human immunology [ 0198-8859 ] ; 2010.
Abstract
Influenza virus remains a significant health concern with current circulating strains that affect millions each year plus the threat of newly emerging strains, such as swine-origin H1N1 and avian H5N1. Our hypothesis is that influenza-derived HLA-Class I-restricted epitopes can be identified for use as a reagent to monitor and quantitate human CD8+ T cell responses and for vaccine development to induce protective cellular immunity. Protein sequences from influenza A virus strains currently in circulation, agents of past pandemics and zoonotic infections of man were evaluated for sequences predicted to bind to alleles representative of the most frequent HLA-A and -B (Class I) types worldwide. Peptides that bound several different HLA molecules and were conserved among diverse influenza subtypes were tested for their capacity to recall influenza-specific immune responses using human donor PBMC. Accordingly, 28 different epitopes antigenic for human donor PBMC were identified and 25 were 100% conserved in the newly emerged swine-origin H1N1 strain. The epitope set defined herein should provide a reagent applicable to quantitate CD8+ T cell human responses irrespective of influenza subtype and HLA composition of the responding population. Additionally, these epitopes may be suitable for vaccine applications directed at the induction of cellular immunity.
Url:
DOI: 10.1016/j.humimm.2010.02.014
PubMed: 20156506
PubMed Central: 2856764
Affiliations:
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PMC:2856764Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Influenza virus remains a significant health concern with current circulating strains that affect millions each year plus the threat of newly emerging strains, such as swine-origin H1N1 and avian H5N1. Our hypothesis is that influenza-derived HLA-Class I-restricted epitopes can be identified for use as a reagent to monitor and quantitate human CD8<sup>+</sup>
T cell responses and for vaccine development to induce protective cellular immunity. Protein sequences from influenza A virus strains currently in circulation, agents of past pandemics and zoonotic infections of man were evaluated for sequences predicted to bind to alleles representative of the most frequent HLA-A and -B (Class I) types worldwide. Peptides that bound several different HLA molecules and were conserved among diverse influenza subtypes were tested for their capacity to recall influenza-specific immune responses using human donor PBMC. Accordingly, 28 different epitopes antigenic for human donor PBMC were identified and 25 were 100% conserved in the newly emerged swine-origin H1N1 strain. The epitope set defined herein should provide a reagent applicable to quantitate CD8<sup>+</sup>
T cell human responses irrespective of influenza subtype and HLA composition of the responding population. Additionally, these epitopes may be suitable for vaccine applications directed at the induction of cellular immunity.</p>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8010936</journal-id>
<journal-id journal-id-type="pubmed-jr-id">4052</journal-id>
<journal-id journal-id-type="nlm-ta">Hum Immunol</journal-id>
<journal-title>Human immunology</journal-title>
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<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Alexander</surname>
<given-names>Jeff</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bilsel</surname>
<given-names>Pamuk</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
<xref rid="FN2" ref-type="author-notes">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>del Guercio</surname>
<given-names>Marie-France</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marinkovic-Petrovic</surname>
<given-names>Aleksandra</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Southwood</surname>
<given-names>Scott</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stewart</surname>
<given-names>Stephani</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ishioka</surname>
<given-names>Glenn</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
<xref rid="FN3" ref-type="author-notes">‡</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kotturi</surname>
<given-names>Maya F.</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Botten</surname>
<given-names>Jason</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sidney</surname>
<given-names>John</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Newman</surname>
<given-names>Mark</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
<xref rid="FN1" ref-type="author-notes">‡</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sette</surname>
<given-names>Alessandro</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Pharmexa-Epimmune Inc., San Diego, California</aff>
<aff id="A2"><label>2</label>
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, San Diego, Calfornia</aff>
<aff id="A3"><label>3</label>
The University of Vermont College of Medicine, Burlington, Vermont</aff>
<author-notes><corresp id="FN1"><label>*</label>
Corresponding Author: Dr. Jeff Alexander, PaxVax, San Diego, CA, 92121, Phone: 858-450-9595 ext. 210, Fax: 858-450-0544, <email>jalexander@paxvax.com</email>
</corresp>
<fn id="FN2" fn-type="present-address"><label>†</label>
<p>Present Address: FluGen, Inc., 545 Science Drive, Madison, WI 53711</p>
</fn>
<fn id="FN3" fn-type="present-address"><label>‡</label>
<p>Present Address: GeoVax Inc, Smyrna, GA, 30080</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>10</day>
<month>3</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>10</day>
<month>3</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><month>5</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>5</month>
<year>2011</year>
</pub-date>
<volume>71</volume>
<issue>5</issue>
<fpage>468</fpage>
<lpage>474</lpage>
<permissions><copyright-statement>© 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2009</copyright-year>
</permissions>
<abstract><p id="P1">Influenza virus remains a significant health concern with current circulating strains that affect millions each year plus the threat of newly emerging strains, such as swine-origin H1N1 and avian H5N1. Our hypothesis is that influenza-derived HLA-Class I-restricted epitopes can be identified for use as a reagent to monitor and quantitate human CD8<sup>+</sup>
T cell responses and for vaccine development to induce protective cellular immunity. Protein sequences from influenza A virus strains currently in circulation, agents of past pandemics and zoonotic infections of man were evaluated for sequences predicted to bind to alleles representative of the most frequent HLA-A and -B (Class I) types worldwide. Peptides that bound several different HLA molecules and were conserved among diverse influenza subtypes were tested for their capacity to recall influenza-specific immune responses using human donor PBMC. Accordingly, 28 different epitopes antigenic for human donor PBMC were identified and 25 were 100% conserved in the newly emerged swine-origin H1N1 strain. The epitope set defined herein should provide a reagent applicable to quantitate CD8<sup>+</sup>
T cell human responses irrespective of influenza subtype and HLA composition of the responding population. Additionally, these epitopes may be suitable for vaccine applications directed at the induction of cellular immunity.</p>
</abstract>
<kwd-group><kwd>Influenza virus</kwd>
<kwd>CTL</kwd>
<kwd>HLA class I</kwd>
<kwd>cellular immunity</kwd>
<kwd>vaccine</kwd>
</kwd-group>
<contract-num rid="AI1">N01 AI030039-009
||AI</contract-num>
<contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor>
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</front>
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<name sortKey="Sidney, John" sort="Sidney, John" uniqKey="Sidney J" first="John" last="Sidney">John Sidney</name>
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<country name="États-Unis"><region name="Californie"><name sortKey="Alexander, Jeff" sort="Alexander, Jeff" uniqKey="Alexander J" first="Jeff" last="Alexander">Jeff Alexander</name>
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<name sortKey="Del Guercio, Marie France" sort="Del Guercio, Marie France" uniqKey="Del Guercio M" first="Marie-France" last="Del Guercio">Marie-France Del Guercio</name>
<name sortKey="Ishioka, Glenn" sort="Ishioka, Glenn" uniqKey="Ishioka G" first="Glenn" last="Ishioka">Glenn Ishioka</name>
<name sortKey="Marinkovic Petrovic, Aleksandra" sort="Marinkovic Petrovic, Aleksandra" uniqKey="Marinkovic Petrovic A" first="Aleksandra" last="Marinkovic-Petrovic">Aleksandra Marinkovic-Petrovic</name>
<name sortKey="Newman, Mark" sort="Newman, Mark" uniqKey="Newman M" first="Mark" last="Newman">Mark Newman</name>
<name sortKey="Southwood, Scott" sort="Southwood, Scott" uniqKey="Southwood S" first="Scott" last="Southwood">Scott Southwood</name>
<name sortKey="Stewart, Stephani" sort="Stewart, Stephani" uniqKey="Stewart S" first="Stephani" last="Stewart">Stephani Stewart</name>
</country>
</tree>
</affiliations>
</record>
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