Immunity to Pre-1950 H1N1 Influenza Viruses Confers Cross-Protection against the Pandemic Swine-Origin 2009 A (H1N1) Influenza Virus
Identifieur interne : 000938 ( Pmc/Checkpoint ); précédent : 000937; suivant : 000939Immunity to Pre-1950 H1N1 Influenza Viruses Confers Cross-Protection against the Pandemic Swine-Origin 2009 A (H1N1) Influenza Virus
Auteurs : Ioanna Skountzou [États-Unis] ; Dimitrios G. Koutsonanos [États-Unis] ; Jin Hyang Kim [États-Unis] ; Ryan Powers [États-Unis] ; Lakshmipriyadarshini Satyabhama [États-Unis] ; Feda Masseoud [États-Unis] ; William C. Weldon [États-Unis] ; Maria Del Pilar Martin [États-Unis] ; Robert S. Mittler [États-Unis] ; Richard Compans [États-Unis] ; Joshy Jacob [États-Unis]Source :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2010.
Abstract
The 2009 H1N1 influenza virus outbreak is the first pandemic of the twenty-first century. Epidemiological data reveal that of all the people afflicted with H1N1 virus, <5% are over 51 y of age. Interestingly, in the uninfected population, 33% of those >60 y old have pre-existing neutralizing Abs against the 2009 H1N1 virus. This finding suggests that influenza strains that circulated 50–60 y ago might provide cross-protection against the swine-origin 2009 H1N1 influenza virus. To test this, we determined the ability of representative H1N1 influenza viruses that circulated in the human population from 1930 to 2000, to induce cross-reactivity to and cross-protection against the pandemic swine-origin H1N1 virus, A/California/04/09. We show that exposure of mice to the 1947 virus, A/FM/1/47, or the 1934 virus, A/PR/8/34, induced robust cross-protective immune responses and these mice were protected against a lethal challenge with mouse-adapted A/California/04/09 H1N1 virus. Conversely, we observed that mice exposed to the 2009 H1N1 virus were protected against a lethal challenge with mouse-adapted 1947 or 1934 H1N1 viruses. In addition, exposure to the 2009 H1N1 virus induced broad cross-reactivity against H1N1 as well as H3N2 influenza viruses. Finally, we show that vaccination with the older H1N1 viruses, particularly A/FM/1/47, confers protective immunity against the 2009 pandemic H1N1 virus. Taken together, our data provide an explanation for the decreased susceptibility of the elderly to the 2009 H1N1 outbreak and demonstrate that vaccination with the pre-1950 influenza strains can cross-protect against the pandemic swine-origin 2009 H1N1 influenza virus.
Url:
DOI: 10.4049/jimmunol.1000091
PubMed: 20585035
PubMed Central: 4457446
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="P1">The 2009 H1N1 influenza virus outbreak is the first pandemic of the twenty-first century. Epidemiological data reveal that of all the people afflicted with H1N1 virus, <5% are over 51 y of age. Interestingly, in the uninfected population, 33% of those >60 y old have pre-existing neutralizing Abs against the 2009 H1N1 virus. This finding suggests that influenza strains that circulated 50–60 y ago might provide cross-protection against the swine-origin 2009 H1N1 influenza virus. To test this, we determined the ability of representative H1N1 influenza viruses that circulated in the human population from 1930 to 2000, to induce cross-reactivity to and cross-protection against the pandemic swine-origin H1N1 virus, A/California/04/09. We show that exposure of mice to the 1947 virus, A/FM/1/47, or the 1934 virus, A/PR/8/34, induced robust cross-protective immune responses and these mice were protected against a lethal challenge with mouse-adapted A/California/04/09 H1N1 virus. Conversely, we observed that mice exposed to the 2009 H1N1 virus were protected against a lethal challenge with mouse-adapted 1947 or 1934 H1N1 viruses. In addition, exposure to the 2009 H1N1 virus induced broad cross-reactivity against H1N1 as well as H3N2 influenza viruses. Finally, we show that vaccination with the older H1N1 viruses, particularly A/FM/1/47, confers protective immunity against the 2009 pandemic H1N1 virus. Taken together, our data provide an explanation for the decreased susceptibility of the elderly to the 2009 H1N1 outbreak and demonstrate that vaccination with the pre-1950 influenza strains can cross-protect against the pandemic swine-origin 2009 H1N1 influenza virus.</p>
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<contrib-group><contrib contrib-type="author"><name><surname>Skountzou</surname>
<given-names>Ioanna</given-names>
</name>
<xref ref-type="aff" rid="A1">*</xref>
<xref ref-type="aff" rid="A2">†</xref>
<xref rid="FN2" ref-type="author-notes">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koutsonanos</surname>
<given-names>Dimitrios G.</given-names>
</name>
<xref ref-type="aff" rid="A2">†</xref>
<xref rid="FN2" ref-type="author-notes">1</xref>
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<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Jin Hyang</given-names>
</name>
<xref ref-type="aff" rid="A1">*</xref>
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<contrib contrib-type="author"><name><surname>Powers</surname>
<given-names>Ryan</given-names>
</name>
<xref ref-type="aff" rid="A1">*</xref>
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<contrib contrib-type="author"><name><surname>Satyabhama</surname>
<given-names>Lakshmipriyadarshini</given-names>
</name>
<xref ref-type="aff" rid="A1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Masseoud</surname>
<given-names>Feda</given-names>
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<xref ref-type="aff" rid="A1">*</xref>
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<given-names>William C.</given-names>
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<xref ref-type="aff" rid="A2">†</xref>
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<contrib contrib-type="author"><name><surname>Martin</surname>
<given-names>Maria del Pilar</given-names>
</name>
<xref ref-type="aff" rid="A1">*</xref>
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<contrib contrib-type="author"><name><surname>Mittler</surname>
<given-names>Robert S.</given-names>
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<xref ref-type="aff" rid="A1">*</xref>
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<contrib contrib-type="author"><name><surname>Compans</surname>
<given-names>Richard</given-names>
</name>
<xref ref-type="aff" rid="A1">*</xref>
<xref ref-type="aff" rid="A2">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jacob</surname>
<given-names>Joshy</given-names>
</name>
<xref ref-type="aff" rid="A1">*</xref>
<xref ref-type="aff" rid="A2">†</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>*</label>
Emory Vaccine Center, Yerkes National Primate Center, Emory University, Atlanta, GA 30329</aff>
<aff id="A2"><label>†</label>
Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322</aff>
<author-notes><corresp id="FN1">Address correspondence and reprint requests to Dr. Joshy Jacob, 954 Gatewood Road, Emory Vaccine Center, Emory University, Atlanta, GA 30329. <email>joshy.jacob@emory.edu</email>
</corresp>
<fn id="FN2" fn-type="equal"><label>1</label>
<p>I.S. and D.G.K. contributed equally to this work.</p>
</fn>
<fn id="FN3" fn-type="conflict"><p><bold>Disclosures</bold>
</p>
<p>The authors have no financial conflicts of interest.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>30</day>
<month>5</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>28</day>
<month>6</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><day>1</day>
<month>8</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>05</day>
<month>6</month>
<year>2015</year>
</pub-date>
<volume>185</volume>
<issue>3</issue>
<fpage>1642</fpage>
<lpage>1649</lpage>
<pmc-comment>elocation-id from pubmed: 10.4049/jimmunol.1000091</pmc-comment>
<permissions><copyright-statement>Copyright © 2010 by The American Association of Immunologists, Inc.</copyright-statement>
<copyright-year>2010</copyright-year>
</permissions>
<abstract><p id="P1">The 2009 H1N1 influenza virus outbreak is the first pandemic of the twenty-first century. Epidemiological data reveal that of all the people afflicted with H1N1 virus, <5% are over 51 y of age. Interestingly, in the uninfected population, 33% of those >60 y old have pre-existing neutralizing Abs against the 2009 H1N1 virus. This finding suggests that influenza strains that circulated 50–60 y ago might provide cross-protection against the swine-origin 2009 H1N1 influenza virus. To test this, we determined the ability of representative H1N1 influenza viruses that circulated in the human population from 1930 to 2000, to induce cross-reactivity to and cross-protection against the pandemic swine-origin H1N1 virus, A/California/04/09. We show that exposure of mice to the 1947 virus, A/FM/1/47, or the 1934 virus, A/PR/8/34, induced robust cross-protective immune responses and these mice were protected against a lethal challenge with mouse-adapted A/California/04/09 H1N1 virus. Conversely, we observed that mice exposed to the 2009 H1N1 virus were protected against a lethal challenge with mouse-adapted 1947 or 1934 H1N1 viruses. In addition, exposure to the 2009 H1N1 virus induced broad cross-reactivity against H1N1 as well as H3N2 influenza viruses. Finally, we show that vaccination with the older H1N1 viruses, particularly A/FM/1/47, confers protective immunity against the 2009 pandemic H1N1 virus. Taken together, our data provide an explanation for the decreased susceptibility of the elderly to the 2009 H1N1 outbreak and demonstrate that vaccination with the pre-1950 influenza strains can cross-protect against the pandemic swine-origin 2009 H1N1 influenza virus.</p>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Géorgie (États-Unis)</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Skountzou, Ioanna" sort="Skountzou, Ioanna" uniqKey="Skountzou I" first="Ioanna" last="Skountzou">Ioanna Skountzou</name>
</region>
<name sortKey="Compans, Richard" sort="Compans, Richard" uniqKey="Compans R" first="Richard" last="Compans">Richard Compans</name>
<name sortKey="Compans, Richard" sort="Compans, Richard" uniqKey="Compans R" first="Richard" last="Compans">Richard Compans</name>
<name sortKey="Jacob, Joshy" sort="Jacob, Joshy" uniqKey="Jacob J" first="Joshy" last="Jacob">Joshy Jacob</name>
<name sortKey="Jacob, Joshy" sort="Jacob, Joshy" uniqKey="Jacob J" first="Joshy" last="Jacob">Joshy Jacob</name>
<name sortKey="Kim, Jin Hyang" sort="Kim, Jin Hyang" uniqKey="Kim J" first="Jin Hyang" last="Kim">Jin Hyang Kim</name>
<name sortKey="Koutsonanos, Dimitrios G" sort="Koutsonanos, Dimitrios G" uniqKey="Koutsonanos D" first="Dimitrios G." last="Koutsonanos">Dimitrios G. Koutsonanos</name>
<name sortKey="Martin, Maria Del Pilar" sort="Martin, Maria Del Pilar" uniqKey="Martin M" first="Maria Del Pilar" last="Martin">Maria Del Pilar Martin</name>
<name sortKey="Masseoud, Feda" sort="Masseoud, Feda" uniqKey="Masseoud F" first="Feda" last="Masseoud">Feda Masseoud</name>
<name sortKey="Mittler, Robert S" sort="Mittler, Robert S" uniqKey="Mittler R" first="Robert S." last="Mittler">Robert S. Mittler</name>
<name sortKey="Powers, Ryan" sort="Powers, Ryan" uniqKey="Powers R" first="Ryan" last="Powers">Ryan Powers</name>
<name sortKey="Satyabhama, Lakshmipriyadarshini" sort="Satyabhama, Lakshmipriyadarshini" uniqKey="Satyabhama L" first="Lakshmipriyadarshini" last="Satyabhama">Lakshmipriyadarshini Satyabhama</name>
<name sortKey="Skountzou, Ioanna" sort="Skountzou, Ioanna" uniqKey="Skountzou I" first="Ioanna" last="Skountzou">Ioanna Skountzou</name>
<name sortKey="Weldon, William C" sort="Weldon, William C" uniqKey="Weldon W" first="William C." last="Weldon">William C. Weldon</name>
</country>
</tree>
</affiliations>
</record>
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