Dual Infection of Novel Influenza Viruses A/H1N1 and A/H3N2 in a Cluster of Cambodian Patients
Identifieur interne : 000837 ( Pmc/Checkpoint ); précédent : 000836; suivant : 000838Dual Infection of Novel Influenza Viruses A/H1N1 and A/H3N2 in a Cluster of Cambodian Patients
Auteurs : Christopher A. Myers ; Matthew R. Kasper ; Chadwick Y. Yasuda ; Chin Savuth ; David J. Spiro ; Rebecca Halpin ; Dennis J. Faix ; Robert Coon ; Shannon D. Putnam ; Thomas F. Wierzba ; Patrick J. BlairSource :
- The American Journal of Tropical Medicine and Hygiene [ 0002-9637 ] ; 2011.
Abstract
During the early months of 2009, a novel influenza A/H1N1 virus (pH1N1) emerged in Mexico and quickly spread across the globe. In October 2009, a 23-year-old male residing in central Cambodia was diagnosed with pH1N1. Subsequently, a cluster of four influenza-like illness cases developed involving three children who resided in his home and the children's school teacher. Base composition analysis of internal genes using reverse transcriptase polymerase chain reaction and electrospray ionization mass spectrometry revealed that specimens from two of the secondary victims were coinfected with influenza A/H3N2 and pH1N1. Phylogenetic analysis of the hemagglutinin genes from these isolated viruses showed that they were closely related to existing pH1N1 and A/H3N2 viruses circulating in the region. Genetic recombination was not evident within plaque-purified viral isolates on full genome sequencing. This incident confirms dual influenza virus infections and highlights the risk of zoonotic and seasonal influenza viruses to coinfect and possibly, reassort where they cocirculate.
Url:
DOI: 10.4269/ajtmh.2011.11-0098
PubMed: 22049058
PubMed Central: 3205650
Affiliations:
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Myers</name></author><author><name sortKey="Kasper, Matthew R" sort="Kasper, Matthew R" uniqKey="Kasper M" first="Matthew R." last="Kasper">Matthew R. Kasper</name></author><author><name sortKey="Yasuda, Chadwick Y" sort="Yasuda, Chadwick Y" uniqKey="Yasuda C" first="Chadwick Y." last="Yasuda">Chadwick Y. Yasuda</name></author><author><name sortKey="Savuth, Chin" sort="Savuth, Chin" uniqKey="Savuth C" first="Chin" last="Savuth">Chin Savuth</name></author><author><name sortKey="Spiro, David J" sort="Spiro, David J" uniqKey="Spiro D" first="David J." last="Spiro">David J. Spiro</name></author><author><name sortKey="Halpin, Rebecca" sort="Halpin, Rebecca" uniqKey="Halpin R" first="Rebecca" last="Halpin">Rebecca Halpin</name></author><author><name sortKey="Faix, Dennis J" sort="Faix, Dennis J" uniqKey="Faix D" first="Dennis J." last="Faix">Dennis J. Faix</name></author><author><name sortKey="Coon, Robert" sort="Coon, Robert" uniqKey="Coon R" first="Robert" last="Coon">Robert Coon</name></author><author><name sortKey="Putnam, Shannon D" sort="Putnam, Shannon D" uniqKey="Putnam S" first="Shannon D." last="Putnam">Shannon D. Putnam</name></author><author><name sortKey="Wierzba, Thomas F" sort="Wierzba, Thomas F" uniqKey="Wierzba T" first="Thomas F." last="Wierzba">Thomas F. Wierzba</name></author><author><name sortKey="Blair, Patrick J" sort="Blair, Patrick J" uniqKey="Blair P" first="Patrick J." last="Blair">Patrick J. Blair</name></author></analytic><series><title level="j">The American Journal of Tropical Medicine and Hygiene</title><idno type="ISSN">0002-9637</idno><idno type="eISSN">1476-1645</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>During the early months of 2009, a novel influenza A/H1N1 virus (pH1N1) emerged in Mexico and quickly spread across the globe. In October 2009, a 23-year-old male residing in central Cambodia was diagnosed with pH1N1. Subsequently, a cluster of four influenza-like illness cases developed involving three children who resided in his home and the children's school teacher. Base composition analysis of internal genes using reverse transcriptase polymerase chain reaction and electrospray ionization mass spectrometry revealed that specimens from two of the secondary victims were coinfected with influenza A/H3N2 and pH1N1. Phylogenetic analysis of the hemagglutinin genes from these isolated viruses showed that they were closely related to existing pH1N1 and A/H3N2 viruses circulating in the region. Genetic recombination was not evident within plaque-purified viral isolates on full genome sequencing. This incident confirms dual influenza virus infections and highlights the risk of zoonotic and seasonal influenza viruses to coinfect and possibly, reassort where they cocirculate.</p></div></front></TEI><pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Trop Med Hyg</journal-id><journal-id journal-id-type="publisher-id">tpmd</journal-id><journal-title-group><journal-title>The American Journal of Tropical Medicine and Hygiene</journal-title></journal-title-group><issn pub-type="ppub">0002-9637</issn><issn pub-type="epub">1476-1645</issn><publisher><publisher-name>The American Society of Tropical Medicine and Hygiene</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22049058</article-id><article-id pub-id-type="pmc">3205650</article-id><article-id pub-id-type="doi">10.4269/ajtmh.2011.11-0098</article-id><article-categories><subj-group subj-group-type="overline"><subject>Short Report</subject></subj-group><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Dual Infection of Novel Influenza Viruses A/H1N1 and A/H3N2 in a Cluster of Cambodian Patients</article-title><alt-title alt-title-type="left-running-head">MYERS AND OTHERS</alt-title><alt-title alt-title-type="right-running-head">DUAL INFLUENZA INFECTIONS, CAMBODIA 2009</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Myers</surname><given-names>Christopher A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kasper</surname><given-names>Matthew R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Yasuda</surname><given-names>Chadwick Y.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Savuth</surname><given-names>Chin</given-names></name></contrib><contrib contrib-type="author"><name><surname>Spiro</surname><given-names>David J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Halpin</surname><given-names>Rebecca</given-names></name></contrib><contrib contrib-type="author"><name><surname>Faix</surname><given-names>Dennis J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Coon</surname><given-names>Robert</given-names></name></contrib><contrib contrib-type="author"><name><surname>Putnam</surname><given-names>Shannon D.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wierzba</surname><given-names>Thomas F.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Blair</surname><given-names>Patrick J.</given-names></name><xref ref-type="corresp" rid="COR1">*</xref></contrib></contrib-group><aff id="AFF1">Naval Health Research Center, San Diego, California; US Naval Medical Research Unit No. 2, Phnom Penh, Kingdom of Cambodia; National Institute of Public Health, Ministry of Health, Phnom Penh, Kingdom of Cambodia; J. Craig Venter Institute, Rockville, Maryland</aff><author-notes><corresp id="COR1">*Address correspondence to Patrick J. Blair, Department of Respiratory Diseases, Naval Health Research Center, 140 Sylvester Road, San Diego, CA 92106. E-mail: <email>patrick.blair@med.navy.mil</email></corresp></author-notes><pub-date pub-type="ppub"><day>01</day><month>11</month><year>2011</year></pub-date><volume>85</volume><issue>5</issue><fpage>961</fpage><lpage>963</lpage><history><date date-type="received"><day>16</day><month>2</month><year>2011</year></date><date date-type="accepted"><day>06</day><month>6</month><year>2011</year></date></history><permissions><copyright-statement>©The American Society of Tropical Medicine and Hygiene</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p>During the early months of 2009, a novel influenza A/H1N1 virus (pH1N1) emerged in Mexico and quickly spread across the globe. In October 2009, a 23-year-old male residing in central Cambodia was diagnosed with pH1N1. Subsequently, a cluster of four influenza-like illness cases developed involving three children who resided in his home and the children's school teacher. Base composition analysis of internal genes using reverse transcriptase polymerase chain reaction and electrospray ionization mass spectrometry revealed that specimens from two of the secondary victims were coinfected with influenza A/H3N2 and pH1N1. Phylogenetic analysis of the hemagglutinin genes from these isolated viruses showed that they were closely related to existing pH1N1 and A/H3N2 viruses circulating in the region. Genetic recombination was not evident within plaque-purified viral isolates on full genome sequencing. This incident confirms dual influenza virus infections and highlights the risk of zoonotic and seasonal influenza viruses to coinfect and possibly, reassort where they cocirculate.</p></abstract></article-meta><notes notes-type="disclaimer"><p>Disclaimer: The views expressed in this article are of the authors and do not reflect the official policy or position of the Department of the Navy, the Department of Defense, or the US Government.</p></notes></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Blair, Patrick J" sort="Blair, Patrick J" uniqKey="Blair P" first="Patrick J." last="Blair">Patrick J. Blair</name><name sortKey="Coon, Robert" sort="Coon, Robert" uniqKey="Coon R" first="Robert" last="Coon">Robert Coon</name><name sortKey="Faix, Dennis J" sort="Faix, Dennis J" uniqKey="Faix D" first="Dennis J." last="Faix">Dennis J. Faix</name><name sortKey="Halpin, Rebecca" sort="Halpin, Rebecca" uniqKey="Halpin R" first="Rebecca" last="Halpin">Rebecca Halpin</name><name sortKey="Kasper, Matthew R" sort="Kasper, Matthew R" uniqKey="Kasper M" first="Matthew R." last="Kasper">Matthew R. Kasper</name><name sortKey="Myers, Christopher A" sort="Myers, Christopher A" uniqKey="Myers C" first="Christopher A." last="Myers">Christopher A. Myers</name><name sortKey="Putnam, Shannon D" sort="Putnam, Shannon D" uniqKey="Putnam S" first="Shannon D." last="Putnam">Shannon D. Putnam</name><name sortKey="Savuth, Chin" sort="Savuth, Chin" uniqKey="Savuth C" first="Chin" last="Savuth">Chin Savuth</name><name sortKey="Spiro, David J" sort="Spiro, David J" uniqKey="Spiro D" first="David J." last="Spiro">David J. Spiro</name><name sortKey="Wierzba, Thomas F" sort="Wierzba, Thomas F" uniqKey="Wierzba T" first="Thomas F." last="Wierzba">Thomas F. Wierzba</name><name sortKey="Yasuda, Chadwick Y" sort="Yasuda, Chadwick Y" uniqKey="Yasuda C" first="Chadwick Y." last="Yasuda">Chadwick Y. Yasuda</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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