Structural basis of influenza virus neutralization
Identifieur interne : 000780 ( Pmc/Checkpoint ); précédent : 000779; suivant : 000781Structural basis of influenza virus neutralization
Auteurs : Thomas Han ; Wayne A. MarascoSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2011.
Abstract
Although seasonal influenza vaccines play a valuable role in reducing the spread of the virus at the population level, ongoing viral evolution to evade immune responses remains problematic. No current vaccines are likely to elicit enduring protection in the face of emerging and re-emerging influenza viruses that rapidly undergoing antigenic drift. Eliciting broadly cross-neutralizing antibody responses against influenza virus is a crucial goal for seasonal and pandemic influenza vaccine preparation. Recent three-dimensional structure information obtained from crystallization of influenza antigens in complex with neutralizing antibodies (nAbs) have provided a framework for interpreting antibody-based viral neutralization that should aid in the design of vaccine immunogens. Here, we will review current knowledge of the structure-based mechanisms contributing to the neutralization and neutralization escape of influenza viruses. We will also explore the potential for this structure-based approach to overcome the challenge of obtaining the highly desired “universal” influenza vaccine.
Url:
DOI: 10.1111/j.1749-6632.2010.05829.x
PubMed: 21251008
PubMed Central: 3062959
Affiliations:
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7506858</journal-id><journal-id journal-id-type="pubmed-jr-id">611</journal-id><journal-id journal-id-type="nlm-ta">Ann N Y Acad Sci</journal-id><journal-title>Annals of the New York Academy of Sciences</journal-title><issn pub-type="ppub">0077-8923</issn><issn pub-type="epub">1749-6632</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21251008</article-id><article-id pub-id-type="pmc">3062959</article-id><article-id pub-id-type="doi">10.1111/j.1749-6632.2010.05829.x</article-id><article-id pub-id-type="manuscript">NIHMS246120</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Structural basis of influenza virus neutralization</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Han</surname><given-names>Thomas</given-names></name></contrib><contrib contrib-type="author"><name><surname>Marasco</surname><given-names>Wayne A.</given-names></name></contrib><aff id="A1">Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA</aff></contrib-group><author-notes><corresp id="CR1">Corresponding author: Wayne A. Marasco, MD, PhD. Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 44 Binney Street, Boston, Massachusetts 02115, USA, <email>wayne_marasco@dfci.harvard.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>11</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>11</day><month>1</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>1</month><year>2012</year></pub-date><volume>1217</volume><fpage>178</fpage><lpage>190</lpage><abstract><p id="P1">Although seasonal influenza vaccines play a valuable role in reducing the spread of the virus at the population level, ongoing viral evolution to evade immune responses remains problematic. No current vaccines are likely to elicit enduring protection in the face of emerging and re-emerging influenza viruses that rapidly undergoing antigenic drift. Eliciting broadly cross-neutralizing antibody responses against influenza virus is a crucial goal for seasonal and pandemic influenza vaccine preparation. Recent three-dimensional structure information obtained from crystallization of influenza antigens in complex with neutralizing antibodies (nAbs) have provided a framework for interpreting antibody-based viral neutralization that should aid in the design of vaccine immunogens. Here, we will review current knowledge of the structure-based mechanisms contributing to the neutralization and neutralization escape of influenza viruses. We will also explore the potential for this structure-based approach to overcome the challenge of obtaining the highly desired “universal” influenza vaccine.</p></abstract><contract-num rid="AI1">U01 AI074518-03
||AI</contract-num><contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Han, Thomas" sort="Han, Thomas" uniqKey="Han T" first="Thomas" last="Han">Thomas Han</name><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A." last="Marasco">Wayne A. Marasco</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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