Advancements in the development of subunit influenza vaccines
Identifieur interne : 000538 ( Pmc/Checkpoint ); précédent : 000537; suivant : 000539Advancements in the development of subunit influenza vaccines
Auteurs : Naru Zhang [États-Unis] ; Bo-Jian Zheng [Hong Kong] ; Lu Lu [République populaire de Chine] ; Yusen Zhou [République populaire de Chine] ; Shibo Jiang [États-Unis, République populaire de Chine] ; Lanying Du [États-Unis]Source :
- Microbes and infection / Institut Pasteur [ 1286-4579 ] ; 2014.
Abstract
The ongoing threat of influenza epidemics and pandemics has emphasized the importance of developing safe and effective vaccines against infections from divergent influenza viruses. In this review, we first introduce the structure and life cycle of influenza A viruses, describing major influenza A virus-caused pandemics. We then compare different types of influenza vaccines and discuss current advancements in the development of subunit influenza vaccines, particularly those based on nucleoprotein (NP), extracellular domain of matrix protein 2 (M2e) and hemagglutinin (HA) proteins. We also illustrate potential strategies for improving the efficacy of subunit influenza vaccines.
Url:
DOI: 10.1016/j.micinf.2014.12.006
PubMed: 25529753
PubMed Central: 4336774
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="P1">The ongoing threat of influenza epidemics and pandemics has emphasized the importance of developing safe and effective vaccines against infections from divergent influenza viruses. In this review, we first introduce the structure and life cycle of influenza A viruses, describing major influenza A virus-caused pandemics. We then compare different types of influenza vaccines and discuss current advancements in the development of subunit influenza vaccines, particularly those based on nucleoprotein (NP), extracellular domain of matrix protein 2 (M2e) and hemagglutinin (HA) proteins. We also illustrate potential strategies for improving the efficacy of subunit influenza vaccines.</p>
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<aff id="A1"><label>1</label>
Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA</aff>
<aff id="A2"><label>2</label>
Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong</aff>
<aff id="A3"><label>3</label>
Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China</aff>
<aff id="A4"><label>4</label>
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China</aff>
<author-notes><corresp id="CR1"><label>*</label>
<bold>Correspondence:</bold>
Tel.: +86 21-54237673; <email>shibojiang@fudan.edu.cn</email>
(S. Jiang); Tel.: +1 212-570-3459; <email>ldu@nybloodcenter.org</email>
(L. Du)</corresp>
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<pmc-comment>elocation-id from pubmed: 10.1016/j.micinf.2014.12.006</pmc-comment>
<permissions><copyright-statement>© 2014 Institut Pasteur. Elsevier Masson SAS. All rights reserved</copyright-statement>
<copyright-year>2014</copyright-year>
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<abstract><p id="P1">The ongoing threat of influenza epidemics and pandemics has emphasized the importance of developing safe and effective vaccines against infections from divergent influenza viruses. In this review, we first introduce the structure and life cycle of influenza A viruses, describing major influenza A virus-caused pandemics. We then compare different types of influenza vaccines and discuss current advancements in the development of subunit influenza vaccines, particularly those based on nucleoprotein (NP), extracellular domain of matrix protein 2 (M2e) and hemagglutinin (HA) proteins. We also illustrate potential strategies for improving the efficacy of subunit influenza vaccines.</p>
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