Evaluation of Multivalent H2 Influenza Pandemic Vaccines in Mice
Identifieur interne : 000238 ( Pmc/Checkpoint ); précédent : 000237; suivant : 000239Evaluation of Multivalent H2 Influenza Pandemic Vaccines in Mice
Auteurs : Brian J. Lenny [États-Unis] ; Stephanie Sonnberg [États-Unis] ; Angela F. Danner [États-Unis] ; Kimberly Friedman [États-Unis] ; Richard J. Webby [États-Unis] ; Robert G. Webster [États-Unis] ; Jeremy C. Jones [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2017.
Abstract
Subtype H2 Influenza A viruses were the cause of a severe pandemic in the winter of 1957. However, this subtype no longer circulates in humans and is no longer included in seasonal vaccines. As a result, individuals under 50 years of age are immunologically naïve. H2 viruses persist in aquatic birds, which were a contributing source for the 1957 pandemic, and have also been isolated from swine. Reintroduction of the H2 via zoonotic transmission has been identified as a pandemic risk, so pre-pandemic planning should include preparation and testing of vaccine candidates against this subtype. We evaluated the immunogenicity of two inactivated, whole virus influenza vaccines (IVV) in mice: a monovalent IVV containing human pandemic virus A/Singapore/1/1957 (H2N2), and a multivalent IVV containing human A/Singapore/1/1957, avian A/Duck/HongKong/319/1978 (H2N2), and swine A/Swine/Missouri/2124514/2006 (H2N3) viruses. While both vaccines induced protective immunity compared to naïve animals, the
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DOI: 10.1016/j.vaccine.2017.01.026
PubMed: 28189402
PubMed Central: 5336516
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Lenny</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Biology, Rhodes College, 2000 North Parkway, Memphis, TN 38112, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Biology, Rhodes College, 2000 North Parkway, Memphis, TN 38112</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Sonnberg, Stephanie" sort="Sonnberg, Stephanie" uniqKey="Sonnberg S" first="Stephanie" last="Sonnberg">Stephanie Sonnberg</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Danner, Angela F" sort="Danner, Angela F" uniqKey="Danner A" first="Angela F." last="Danner">Angela F. Danner</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Friedman, Kimberly" sort="Friedman, Kimberly" uniqKey="Friedman K" first="Kimberly" last="Friedman">Kimberly Friedman</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J." last="Webby">Richard J. 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Lenny</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Biology, Rhodes College, 2000 North Parkway, Memphis, TN 38112, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Biology, Rhodes College, 2000 North Parkway, Memphis, TN 38112</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Sonnberg, Stephanie" sort="Sonnberg, Stephanie" uniqKey="Sonnberg S" first="Stephanie" last="Sonnberg">Stephanie Sonnberg</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Danner, Angela F" sort="Danner, Angela F" uniqKey="Danner A" first="Angela F." last="Danner">Angela F. Danner</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Friedman, Kimberly" sort="Friedman, Kimberly" uniqKey="Friedman K" first="Kimberly" last="Friedman">Kimberly Friedman</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J." last="Webby">Richard J. Webby</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Jones, Jeremy C" sort="Jones, Jeremy C" uniqKey="Jones J" first="Jeremy C." last="Jones">Jeremy C. Jones</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Subtype H2 Influenza A viruses were the cause of a severe pandemic in the winter of 1957. However, this subtype no longer circulates in humans and is no longer included in seasonal vaccines. As a result, individuals under 50 years of age are immunologically naïve. H2 viruses persist in aquatic birds, which were a contributing source for the 1957 pandemic, and have also been isolated from swine. Reintroduction of the H2 via zoonotic transmission has been identified as a pandemic risk, so pre-pandemic planning should include preparation and testing of vaccine candidates against this subtype. We evaluated the immunogenicity of two inactivated, whole virus influenza vaccines (IVV) in mice: a monovalent IVV containing human pandemic virus A/Singapore/1/1957 (H2N2), and a multivalent IVV containing human A/Singapore/1/1957, avian A/Duck/HongKong/319/1978 (H2N2), and swine A/Swine/Missouri/2124514/2006 (H2N3) viruses. While both vaccines induced protective immunity compared to naïve animals, the <bold>multivalent</bold> formulation was advantageous over the monovalent in terms of level and breadth of serological responses, <bold>neutralization of infectious virus</bold>, and reduction of clinical disease and respiratory tissue replication in mice. Therefore, <bold>multivalent</bold> pandemic H2 vaccines containing diverse viruses from animal reservoirs, are a potential option to improve the immune responses in a pre-pandemic scenario where antigenic identity cannot be predicted.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8406899</journal-id><journal-id journal-id-type="pubmed-jr-id">7945</journal-id><journal-id journal-id-type="nlm-ta">Vaccine</journal-id><journal-id journal-id-type="iso-abbrev">Vaccine</journal-id><journal-title-group><journal-title>Vaccine</journal-title></journal-title-group><issn pub-type="ppub">0264-410X</issn><issn pub-type="epub">1873-2518</issn></journal-meta><article-meta><article-id pub-id-type="pmid">28189402</article-id><article-id pub-id-type="pmc">5336516</article-id><article-id pub-id-type="doi">10.1016/j.vaccine.2017.01.026</article-id><article-id pub-id-type="manuscript">NIHMS847399</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Evaluation of Multivalent H2 Influenza Pandemic Vaccines in Mice</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Lenny</surname><given-names>Brian J.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Sonnberg</surname><given-names>Stephanie</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Danner</surname><given-names>Angela F.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Friedman</surname><given-names>Kimberly</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Webby</surname><given-names>Richard J.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Webster</surname><given-names>Robert G.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>Jeremy C.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="corresp" rid="CR1">#</xref></contrib></contrib-group><aff id="A1"><label>a</label> Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA</aff><aff id="A2"><label>b</label> Department of Biology, Rhodes College, 2000 North Parkway, Memphis, TN 38112, USA</aff><author-notes><fn fn-type="present-address" id="FN1"><label>*</label><p id="P1">Present Address: Takeda Vaccines Inc., 504 S. Rosa Road, Madison, WI 53719, USA</p></fn><corresp id="CR1"><label>#</label><bold>Corresponding Author</bold>: Jeremy C. Jones, Department of Infectious Diseases, Virology Division, St. Jude Children's Research Hospital, 262 Danny Thomas Place MS330, Memphis, TN 38120, <email>jeremy.jones@stjude.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>10</day><month>2</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>08</day><month>2</month><year>2017</year></pub-date><pub-date pub-type="ppub"><day>07</day><month>3</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>07</day><month>3</month><year>2018</year></pub-date><volume>35</volume><issue>10</issue><fpage>1455</fpage><lpage>1463</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.vaccine.2017.01.026</pmc-comment>
<abstract><p id="P2">Subtype H2 Influenza A viruses were the cause of a severe pandemic in the winter of 1957. However, this subtype no longer circulates in humans and is no longer included in seasonal vaccines. As a result, individuals under 50 years of age are immunologically naïve. H2 viruses persist in aquatic birds, which were a contributing source for the 1957 pandemic, and have also been isolated from swine. Reintroduction of the H2 via zoonotic transmission has been identified as a pandemic risk, so pre-pandemic planning should include preparation and testing of vaccine candidates against this subtype. We evaluated the immunogenicity of two inactivated, whole virus influenza vaccines (IVV) in mice: a monovalent IVV containing human pandemic virus A/Singapore/1/1957 (H2N2), and a multivalent IVV containing human A/Singapore/1/1957, avian A/Duck/HongKong/319/1978 (H2N2), and swine A/Swine/Missouri/2124514/2006 (H2N3) viruses. While both vaccines induced protective immunity compared to naïve animals, the <bold>multivalent</bold> formulation was advantageous over the monovalent in terms of level and breadth of serological responses, <bold>neutralization of infectious virus</bold>, and reduction of clinical disease and respiratory tissue replication in mice. Therefore, <bold>multivalent</bold> pandemic H2 vaccines containing diverse viruses from animal reservoirs, are a potential option to improve the immune responses in a pre-pandemic scenario where antigenic identity cannot be predicted.</p></abstract><kwd-group><kwd>Influenza</kwd><kwd>Vaccine</kwd><kwd>Pandemic</kwd><kwd>H2N2</kwd><kwd>Monovalent</kwd><kwd>Multivalent</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Lenny, Brian J" sort="Lenny, Brian J" uniqKey="Lenny B" first="Brian J." last="Lenny">Brian J. Lenny</name></region><name sortKey="Danner, Angela F" sort="Danner, Angela F" uniqKey="Danner A" first="Angela F." last="Danner">Angela F. Danner</name><name sortKey="Friedman, Kimberly" sort="Friedman, Kimberly" uniqKey="Friedman K" first="Kimberly" last="Friedman">Kimberly Friedman</name><name sortKey="Jones, Jeremy C" sort="Jones, Jeremy C" uniqKey="Jones J" first="Jeremy C." last="Jones">Jeremy C. Jones</name><name sortKey="Lenny, Brian J" sort="Lenny, Brian J" uniqKey="Lenny B" first="Brian J." last="Lenny">Brian J. Lenny</name><name sortKey="Sonnberg, Stephanie" sort="Sonnberg, Stephanie" uniqKey="Sonnberg S" first="Stephanie" last="Sonnberg">Stephanie Sonnberg</name><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J." last="Webby">Richard J. Webby</name><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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