Influenza virus specific human antibody repertoire studies
Identifieur interne : 000056 ( Pmc/Checkpoint ); précédent : 000055; suivant : 000057Influenza virus specific human antibody repertoire studies
Auteurs : James E. Crowe [États-Unis]Source :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2019.
Abstract
The diversity of antigen specific adaptive receptors on the surface of B cells and in the population of secreted antibodies is enormous, but increasingly we are acquiring the technical capability to interrogate antibody repertoires in great detail. These antibody technologies have been especially pointed at understanding the complex issues of immunity to infection and disease caused by influenza virus, one of the most common and vexing medical problems in man. Influenza immunity is particularly interesting as a model system, because the antigenic diversity of influenza strains and proteins is high and constantly evolving. Discovery of canonical features in the subset of the influenza repertoire response that is broadly reactive for diverse influenza strains has spurred the recent optimism for creating universal influenza vaccines. Using new technologies for sequencing antibody repertoires at great depth is helping us to understand the central features of influenza immunity.
Url:
DOI: 10.4049/jimmunol.1801459
PubMed: 30617118
PubMed Central: 6327975
Affiliations:
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PMC:6327975Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">The diversity of antigen specific adaptive receptors on the surface of B cells and in the population of secreted antibodies is enormous, but increasingly we are acquiring the technical capability to interrogate antibody repertoires in great detail. These antibody technologies have been especially pointed at understanding the complex issues of immunity to infection and disease caused by influenza virus, one of the most common and vexing medical problems in man. Influenza immunity is particularly interesting as a model system, because the antigenic diversity of influenza strains and proteins is high and constantly evolving. Discovery of canonical features in the subset of the influenza repertoire response that is broadly reactive for diverse influenza strains has spurred the recent optimism for creating universal influenza vaccines. Using new technologies for sequencing antibody repertoires at great depth is helping us to understand the central features of influenza immunity.</p>
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<title-group><article-title>Influenza virus specific human antibody repertoire studies</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Crowe</surname>
<given-names>James E.</given-names>
<suffix>Jr.</suffix>
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<xref ref-type="aff" rid="A1">1</xref>
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<aff id="A1"><label>1</label>
Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.</aff>
<aff id="A2"><label>2</label>
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.</aff>
<aff id="A3"><label>3</label>
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.</aff>
<author-notes><corresp id="CR1"><bold><underline>Contact Information:</underline>
James E. Crowe, Jr., M.D.</bold>
, Ann Scott Carell Chair, Departments of Pediatrics, and Pathology, Microbiology and Immunology, Director, Vanderbilt Vaccine Center, <bold>Mail:</bold>
Vanderbilt Vaccine Center, 11475 Medical Research Building IV, 2213 Garland Avenue, Nashville, TN 37232-0417, USA, <bold>Telephone</bold>
(615) 343-8064</corresp>
<corresp id="CR2"><bold>Author Information Statement</bold>
. Address requests for reprints and permissions to James E. Crowe, Jr.;</corresp>
<corresp id="CR3"><bold>Correspondence.</bold>
Address correspondence to James E. Crowe, Jr.; <email>james.crowe@vanderbilt.edu</email>
</corresp>
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<pub-date pub-type="nihms-submitted"><day>13</day>
<month>12</month>
<year>2018</year>
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<pub-date pub-type="ppub"><day>15</day>
<month>1</month>
<year>2019</year>
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<pub-date pub-type="pmc-release"><day>15</day>
<month>1</month>
<year>2020</year>
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<volume>202</volume>
<issue>2</issue>
<fpage>368</fpage>
<lpage>373</lpage>
<pmc-comment>elocation-id from pubmed: 10.4049/jimmunol.1801459</pmc-comment>
<abstract id="ABS1"><p id="P1">The diversity of antigen specific adaptive receptors on the surface of B cells and in the population of secreted antibodies is enormous, but increasingly we are acquiring the technical capability to interrogate antibody repertoires in great detail. These antibody technologies have been especially pointed at understanding the complex issues of immunity to infection and disease caused by influenza virus, one of the most common and vexing medical problems in man. Influenza immunity is particularly interesting as a model system, because the antigenic diversity of influenza strains and proteins is high and constantly evolving. Discovery of canonical features in the subset of the influenza repertoire response that is broadly reactive for diverse influenza strains has spurred the recent optimism for creating universal influenza vaccines. Using new technologies for sequencing antibody repertoires at great depth is helping us to understand the central features of influenza immunity.</p>
</abstract>
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