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Prior H1N1 influenza infection and susceptibility of cleveland family study participants during the H2N2 pandemic of 1957 : An experiment of nature. Commentary

Identifieur interne : 000025 ( PascalFrancis/Curation ); précédent : 000024; suivant : 000026

Prior H1N1 influenza infection and susceptibility of cleveland family study participants during the H2N2 pandemic of 1957 : An experiment of nature. Commentary

Auteurs : Edwin D. Kilbourne [États-Unis] ; Suzanne L. Epstein [États-Unis]

Source :

RBID : Pascal:06-0108310

Descripteurs français

English descriptors

Abstract

During a pandemic, influenza vaccines that rely on neutralizing antibodies to protect against matched viruses might not be available early enough. Much broader (heterosubtypic) immune protection is seen in animals. Do humans also have cross-subtype immunity? To investigate this issue, archival records from the Cleveland Family Study, which was conducted before and during the 1957 pandemic (during which a shift from subtype H1N1 to H2N2 occurred), were analyzed. Only 5.6% of the adults who had had symptomatic influenza A in earlier study years developed influenza during the pandemic, despite living in households with participants who had influenza. In contrast, 55.2% of the children who had had symptomatic influenza A contracted it again. These findings suggest an impact of accumulated heterosubtypic immunity during a pandemic. Such immunity, as well as its implications for vaccination, should be further investigated.
pA  
A01 01  1    @0 0022-1899
A02 01      @0 JIDIAQ
A03   1    @0 J. infect. dis.
A05       @2 193
A06       @2 1
A08 01  1  ENG  @1 Prior H1N1 influenza infection and susceptibility of cleveland family study participants during the H2N2 pandemic of 1957 : An experiment of nature. Commentary
A11 01  1    @1 KILBOURNE (Edwin D.) @9 comment.
A11 02  1    @1 EPSTEIN (Suzanne L.)
A14 01      @1 Department of Microbiology and Immunology, New York Medical College @2 Valhalla @3 USA @Z 1 aut.
A14 02      @1 Laboratory of Immunology and Developmental Biology, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologies Evaluation and Research, Food and Drug Administration @2 Rockville, Maryland @3 USA @Z 2 aut.
A20       @2 7-8,49-53 [7 p.]
A21       @1 2006
A23 01      @0 ENG
A43 01      @1 INIST @2 2052 @5 354000133238380060
A44       @0 0000 @1 © 2006 INIST-CNRS. All rights reserved.
A45       @0 29 ref.
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A60       @1 P @3 CC @3 CT
A61       @0 A
A64 01  1    @0 The Journal of infectious diseases
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C01 01    ENG  @0 During a pandemic, influenza vaccines that rely on neutralizing antibodies to protect against matched viruses might not be available early enough. Much broader (heterosubtypic) immune protection is seen in animals. Do humans also have cross-subtype immunity? To investigate this issue, archival records from the Cleveland Family Study, which was conducted before and during the 1957 pandemic (during which a shift from subtype H1N1 to H2N2 occurred), were analyzed. Only 5.6% of the adults who had had symptomatic influenza A in earlier study years developed influenza during the pandemic, despite living in households with participants who had influenza. In contrast, 55.2% of the children who had had symptomatic influenza A contracted it again. These findings suggest an impact of accumulated heterosubtypic immunity during a pandemic. Such immunity, as well as its implications for vaccination, should be further investigated.
C02 01  X    @0 002A05
C02 02  X    @0 002B05
C03 01  X  FRE  @0 Sensibilité @5 05
C03 01  X  ENG  @0 Sensitivity @5 05
C03 01  X  SPA  @0 Sensibilidad @5 05
C03 02  X  FRE  @0 Microbiologie @5 06
C03 02  X  ENG  @0 Microbiology @5 06
C03 02  X  SPA  @0 Microbiología @5 06
C03 03  X  FRE  @0 Infection @5 07
C03 03  X  ENG  @0 Infection @5 07
C03 03  X  SPA  @0 Infección @5 07
C03 04  X  FRE  @0 Grippe @5 14
C03 04  X  ENG  @0 Influenza @5 14
C03 04  X  SPA  @0 Gripe @5 14
C07 01  X  FRE  @0 Virose
C07 01  X  ENG  @0 Viral disease
C07 01  X  SPA  @0 Virosis
N21       @1 065
N44 01      @1 OTO
N82       @1 OTO

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