H2N2V1, PascalFrancis, Corpus, bibRecord, 000091

The immunogenicity of reassortants of the cold-adapted influenza A master strain A/Ann Arbor/6/60 is determined by both the genes for cold-adaptation and the haemagglutinin gene

Identifieur interne : 000091 ( PascalFrancis/Corpus ); précédent : 000090; suivant : 000092

The immunogenicity of reassortants of the cold-adapted influenza A master strain A/Ann Arbor/6/60 is determined by both the genes for cold-adaptation and the haemagglutinin gene

Auteurs : G. A. Tannock ; J. R. Romanova ; J. A. Paul

Source :

Archives of virology [ 0304-8608 ] ; 1995.

RBID : Pascal:95-0141912

Descripteurs français

Pascal (Inist)
- Influenzavirus A, Souche atténuée, Adaptation, Froid, Hémagglutinine, Relation structure propriété, Immunogénicité, Immunisation, Souris, Voie intranasale, Réassortiment génétique.

English descriptors

KwdEn :
- Adaptation, Attenuated strain, Cold, Genetic reassortment, Hemagglutinin, Immunization, Immunogenicity, Influenzavirus A, Intranasally administration, Mouse, Property structure relationship.

Abstract

Two surface antigen segregants were prepared by co-infection of chicken embryo kidney cell cultures with reassortants of the cold-adapted influenza A master strain A/Ann Arbor/6/60-ca (H2N2) possessing the surface antigens of A/Queensland /6 /72 (H3N2) and A/Hong Kong/123/77 (H1N1) and other genes that were common to the master strain. The segregants were shown by serological tests to possess H3N1 and H1N2 surface antigens but it was not possible to determine the presence of HI or NI genes by single-stranded RNA polyacrylamide gel electrophoresis. The immunogenic properties of A/Queensland /6/72-ca and H3N1 segregant CR6/35/2/9 were compared by immunising mice intranasally with graded doses of each virus twice at an interval of 3 weeks and then challenging with the wild-type A/Queensland/6/72 (H3N2). Clearance of the challenge virus occurred in mice immunised with the same vaccinating dose, indicating that the immunogenicity of both the ca H3N2 and H3N1 viruses was identical and similar findings were obtained for mice immunised with A/Hong Kong/123/77-ca and the H1N2 segregant CR6/35/1/19 and challenged with the wild-type A/Hong Kong/123/77. Therefore, there appears to be a good correlation between immunogenicity and the inheritance of the haemagglutinin gene

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 95-0141912 INIST
ET :	The immunogenicity of reassortants of the cold-adapted influenza A master strain A/Ann Arbor/6/60 is determined by both the genes for cold-adaptation and the haemagglutinin gene
AU :	TANNOCK (G. A.); ROMANOVA (J. R.); PAUL (J. A.)
AF :	Royal Melbourne inst. technology, dep. applied biotechnology/Melbourne Victoria 3001/Australie (1 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Archives of virology; ISSN 0304-8608; Autriche; Da. 1995; Vol. 140; No. 1; Pp. 201-209; Bibl. 9 ref.
LA :	Anglais
EA :	Two surface antigen segregants were prepared by co-infection of chicken embryo kidney cell cultures with reassortants of the cold-adapted influenza A master strain A/Ann Arbor/6/60-ca (H2N2) possessing the surface antigens of A/Queensland /6 /72 (H3N2) and A/Hong Kong/123/77 (H1N1) and other genes that were common to the master strain. The segregants were shown by serological tests to possess H3N1 and H1N2 surface antigens but it was not possible to determine the presence of HI or NI genes by single-stranded RNA polyacrylamide gel electrophoresis. The immunogenic properties of A/Queensland /6/72-ca and H3N1 segregant CR6/35/2/9 were compared by immunising mice intranasally with graded doses of each virus twice at an interval of 3 weeks and then challenging with the wild-type A/Queensland/6/72 (H3N2). Clearance of the challenge virus occurred in mice immunised with the same vaccinating dose, indicating that the immunogenicity of both the ca H3N2 and H3N1 viruses was identical and similar findings were obtained for mice immunised with A/Hong Kong/123/77-ca and the H1N2 segregant CR6/35/1/19 and challenged with the wild-type A/Hong Kong/123/77. Therefore, there appears to be a good correlation between immunogenicity and the inheritance of the haemagglutinin gene
CC :	002A05C07
FD :	Influenzavirus A; Souche atténuée; Adaptation; Froid; Hémagglutinine; Relation structure propriété; Immunogénicité; Immunisation; Souris; Voie intranasale; Réassortiment génétique
FG :	Influenzavirus; Orthomyxoviridae; Virus; Rodentia; Mammalia; Vertebrata; Glycoprotéine
ED :	Influenzavirus A; Attenuated strain; Adaptation; Cold; Hemagglutinin; Property structure relationship; Immunogenicity; Immunization; Mouse; Intranasally administration; Genetic reassortment
EG :	Influenzavirus; Orthomyxoviridae; Virus; Rodentia; Mammalia; Vertebrata; Glycoproteins
SD :	Influenzavirus A; Cepa atenuada; Adaptación; Frío; Hemoaglutinina; Relación estructura propiedad; Inmunogenicidad; Inmunización; Ratón; Vía intranasal
LO :	INIST-6355.354000059268530180
ID :	95-0141912

Links to Exploration step

Pascal:95-0141912

Le document en format XML

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<front><div type="abstract" xml:lang="en">Two surface antigen segregants were prepared by co-infection of chicken embryo kidney cell cultures with reassortants of the cold-adapted influenza A master strain A/Ann Arbor/6/60-ca (H2N2) possessing the surface antigens of A/Queensland /6 /72 (H3N2) and A/Hong Kong/123/77 (H1N1) and other genes that were common to the master strain. The segregants were shown by serological tests to possess H3N1 and H1N2 surface antigens but it was not possible to determine the presence of HI or NI genes by single-stranded RNA polyacrylamide gel electrophoresis. The immunogenic properties of A/Queensland /6/72-ca and H3N1 segregant CR6/35/2/9 were compared by immunising mice intranasally with graded doses of each virus twice at an interval of 3 weeks and then challenging with the wild-type A/Queensland/6/72 (H3N2). Clearance of the challenge virus occurred in mice immunised with the same vaccinating dose, indicating that the immunogenicity of both the ca H3N2 and H3N1 viruses was identical and similar findings were obtained for mice immunised with A/Hong Kong/123/77-ca and the H1N2 segregant CR6/35/1/19 and challenged with the wild-type A/Hong Kong/123/77. Therefore, there appears to be a good correlation between immunogenicity and the inheritance of the haemagglutinin gene</div>
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<s4>CD</s4>
<s5>96</s5>
</fC03>
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<s4>CD</s4>
<s5>96</s5>
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<fC07 i1="01" i2="X" l="SPA"><s0>Influenzavirus</s0>
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<s2>NW</s2>
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<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Glycoprotéine</s0>
<s5>27</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Glycoproteins</s0>
<s5>27</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Glicoproteina</s0>
<s5>27</s5>
</fC07>
<fN21><s1>088</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 95-0141912 INIST</NO>
<ET>The immunogenicity of reassortants of the cold-adapted influenza A master strain A/Ann Arbor/6/60 is determined by both the genes for cold-adaptation and the haemagglutinin gene</ET>
<AU>TANNOCK (G. A.); ROMANOVA (J. R.); PAUL (J. A.)</AU>
<AF>Royal Melbourne inst. technology, dep. applied biotechnology/Melbourne Victoria 3001/Australie (1 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Archives of virology; ISSN 0304-8608; Autriche; Da. 1995; Vol. 140; No. 1; Pp. 201-209; Bibl. 9 ref.</SO>
<LA>Anglais</LA>
<EA>Two surface antigen segregants were prepared by co-infection of chicken embryo kidney cell cultures with reassortants of the cold-adapted influenza A master strain A/Ann Arbor/6/60-ca (H2N2) possessing the surface antigens of A/Queensland /6 /72 (H3N2) and A/Hong Kong/123/77 (H1N1) and other genes that were common to the master strain. The segregants were shown by serological tests to possess H3N1 and H1N2 surface antigens but it was not possible to determine the presence of HI or NI genes by single-stranded RNA polyacrylamide gel electrophoresis. The immunogenic properties of A/Queensland /6/72-ca and H3N1 segregant CR6/35/2/9 were compared by immunising mice intranasally with graded doses of each virus twice at an interval of 3 weeks and then challenging with the wild-type A/Queensland/6/72 (H3N2). Clearance of the challenge virus occurred in mice immunised with the same vaccinating dose, indicating that the immunogenicity of both the ca H3N2 and H3N1 viruses was identical and similar findings were obtained for mice immunised with A/Hong Kong/123/77-ca and the H1N2 segregant CR6/35/1/19 and challenged with the wild-type A/Hong Kong/123/77. Therefore, there appears to be a good correlation between immunogenicity and the inheritance of the haemagglutinin gene</EA>
<CC>002A05C07</CC>
<FD>Influenzavirus A; Souche atténuée; Adaptation; Froid; Hémagglutinine; Relation structure propriété; Immunogénicité; Immunisation; Souris; Voie intranasale; Réassortiment génétique</FD>
<FG>Influenzavirus; Orthomyxoviridae; Virus; Rodentia; Mammalia; Vertebrata; Glycoprotéine</FG>
<ED>Influenzavirus A; Attenuated strain; Adaptation; Cold; Hemagglutinin; Property structure relationship; Immunogenicity; Immunization; Mouse; Intranasally administration; Genetic reassortment</ED>
<EG>Influenzavirus; Orthomyxoviridae; Virus; Rodentia; Mammalia; Vertebrata; Glycoproteins</EG>
<SD>Influenzavirus A; Cepa atenuada; Adaptación; Frío; Hemoaglutinina; Relación estructura propiedad; Inmunogenicidad; Inmunización; Ratón; Vía intranasal</SD>
<LO>INIST-6355.354000059268530180</LO>
<ID>95-0141912</ID>
</server>
</inist>
</record>

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The immunogenicity of reassortants of the cold-adapted influenza A master strain A/Ann Arbor/6/60 is determined by both the genes for cold-adaptation and the haemagglutinin gene

The immunogenicity of reassortants of the cold-adapted influenza A master strain A/Ann Arbor/6/60 is determined by both the genes for cold-adaptation and the haemagglutinin gene

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