En Russe
Identifieur interne : 000062 ( PascalFrancis/Corpus ); précédent : 000061; suivant : 000063En Russe
Auteurs : I. V. Kiseleva ; A. I. KlimovSource :
- Voprosy virusologii [ 0507-4088 ] ; 2002.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Cold-adapted influenza viruses A/Leningrad/13 4/17/5 7 (H2N2) (Len/17) and A/Leningrad/ 34/4 7/57 (H2N2) (Len/ 47) are used in Russia to prepare live reassortant cold-adapted Influenza vaccines (LIV) for adults and children, respectively. Comparison between the nucleotide sequences of the Len/17 strain and the initial wild-type strain A/Leningrad/13 4/5 7 (H2N2) revealed ten nucleotide substitutions (eight of them encoding). Four additional substitutions (three encoding) were found in the genome of the Len/47 virus. Gene segment restriction site (PCR-restriction) analysis was used for identification of the genotype of reassortant Influenza viruses. Conventional methods of PCR-restriction analysis detect only five encoding nucleotide substitutions in the Internal genes of the Len/ 17 and seven substitutions in the internal genes of the Len/47 virus. An extended modification of the PCR-restriction method detect all encoding mutations in the internal genes of the Len/17 and Len/47 viruses (eight and eleven encoding substitutions, respectively). This method is advantageous for genome composition analysis of reassortant influenza vaccine strains and for investigating the genetic stability of LIV during replication In vaccines.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 03-0248622 INIST |
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ET : | (Analysis of mutations in the genome of cold-adapted strains of influenza a virus using extended modification of polymerase chain reaction restriction method) |
OT : | En Russe |
AU : | KISELEVA (I. V.); KLIMOV (A. I.) |
DT : | Publication en série; Niveau analytique |
SO : | Voprosy virusologii; ISSN 0507-4088; Coden VVIRAT; Russie; Da. 2002; Vol. 47; No. 6; Pp. 24-26; Abs. anglais; Bibl. 5 ref. |
LA : | Russe |
EA : | Cold-adapted influenza viruses A/Leningrad/13 4/17/5 7 (H2N2) (Len/17) and A/Leningrad/ 34/4 7/57 (H2N2) (Len/ 47) are used in Russia to prepare live reassortant cold-adapted Influenza vaccines (LIV) for adults and children, respectively. Comparison between the nucleotide sequences of the Len/17 strain and the initial wild-type strain A/Leningrad/13 4/5 7 (H2N2) revealed ten nucleotide substitutions (eight of them encoding). Four additional substitutions (three encoding) were found in the genome of the Len/47 virus. Gene segment restriction site (PCR-restriction) analysis was used for identification of the genotype of reassortant Influenza viruses. Conventional methods of PCR-restriction analysis detect only five encoding nucleotide substitutions in the Internal genes of the Len/ 17 and seven substitutions in the internal genes of the Len/47 virus. An extended modification of the PCR-restriction method detect all encoding mutations in the internal genes of the Len/17 and Len/47 viruses (eight and eleven encoding substitutions, respectively). This method is advantageous for genome composition analysis of reassortant influenza vaccine strains and for investigating the genetic stability of LIV during replication In vaccines. |
CC : | 002A05C07 |
FD : | Influenzavirus A; Virus grippal A; Vaccin; Génotype; Réaction chaîne polymérase; Mutation; Grippe A |
FG : | Orthomyxoviridae; Virus; Virose; Infection |
ED : | Influenzavirus A; Influenza A virus; Vaccine; Genotype; Polymerase chain reaction; Mutation; Influenza A |
EG : | Orthomyxoviridae; Virus; Viral disease; Infection |
SD : | Influenzavirus A; Influenza A virus; Vacuna; Genotipo; Reacción cadena polimerasa; Mutación; Gripe A |
LO : | INIST-8812.354000105612320060 |
ID : | 03-0248622 |
Links to Exploration step
Pascal:03-0248622Le document en format XML
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<front><div type="abstract" xml:lang="en">Cold-adapted influenza viruses A/Leningrad/13 4/17/5 7 (H2N2) (Len/17) and A/Leningrad/ 34/4 7/57 (H2N2) (Len/ 47) are used in Russia to prepare live reassortant cold-adapted Influenza vaccines (LIV) for adults and children, respectively. Comparison between the nucleotide sequences of the Len/17 strain and the initial wild-type strain A/Leningrad/13 4/5 7 (H2N2) revealed ten nucleotide substitutions (eight of them encoding). Four additional substitutions (three encoding) were found in the genome of the Len/47 virus. Gene segment restriction site (PCR-restriction) analysis was used for identification of the genotype of reassortant Influenza viruses. Conventional methods of PCR-restriction analysis detect only five encoding nucleotide substitutions in the Internal genes of the Len/ 17 and seven substitutions in the internal genes of the Len/47 virus. An extended modification of the PCR-restriction method detect all encoding mutations in the internal genes of the Len/17 and Len/47 viruses (eight and eleven encoding substitutions, respectively). This method is advantageous for genome composition analysis of reassortant influenza vaccine strains and for investigating the genetic stability of LIV during replication In vaccines.</div>
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<server><NO>PASCAL 03-0248622 INIST</NO>
<ET>(Analysis of mutations in the genome of cold-adapted strains of influenza a virus using extended modification of polymerase chain reaction restriction method)</ET>
<OT>En Russe</OT>
<AU>KISELEVA (I. V.); KLIMOV (A. I.)</AU>
<DT>Publication en série; Niveau analytique</DT>
<SO>Voprosy virusologii; ISSN 0507-4088; Coden VVIRAT; Russie; Da. 2002; Vol. 47; No. 6; Pp. 24-26; Abs. anglais; Bibl. 5 ref.</SO>
<LA>Russe</LA>
<EA>Cold-adapted influenza viruses A/Leningrad/13 4/17/5 7 (H2N2) (Len/17) and A/Leningrad/ 34/4 7/57 (H2N2) (Len/ 47) are used in Russia to prepare live reassortant cold-adapted Influenza vaccines (LIV) for adults and children, respectively. Comparison between the nucleotide sequences of the Len/17 strain and the initial wild-type strain A/Leningrad/13 4/5 7 (H2N2) revealed ten nucleotide substitutions (eight of them encoding). Four additional substitutions (three encoding) were found in the genome of the Len/47 virus. Gene segment restriction site (PCR-restriction) analysis was used for identification of the genotype of reassortant Influenza viruses. Conventional methods of PCR-restriction analysis detect only five encoding nucleotide substitutions in the Internal genes of the Len/ 17 and seven substitutions in the internal genes of the Len/47 virus. An extended modification of the PCR-restriction method detect all encoding mutations in the internal genes of the Len/17 and Len/47 viruses (eight and eleven encoding substitutions, respectively). This method is advantageous for genome composition analysis of reassortant influenza vaccine strains and for investigating the genetic stability of LIV during replication In vaccines.</EA>
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