Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus ?
Identifieur interne : 000091 ( PascalFrancis/Checkpoint ); précédent : 000090; suivant : 000092Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus ?
Auteurs : D. Cotter [Irlande (pays)] ; N. Takei ; M. Farrell ; PAK SHAM ; P. Quinn ; C. Larkin [Irlande (pays)] ; J. Oxford ; R. M. Murray ; E. O'Callaghan [Irlande (pays)]Source :
- Schizophrenia research [ 0920-9964 ] ; 1995.
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Abstract
Epidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9-16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.
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Farrell</name></author><author><name sortKey="Pak Sham" sort="Pak Sham" uniqKey="Pak Sham" last="Pak Sham">PAK SHAM</name></author><author><name sortKey="Quinn, P" sort="Quinn, P" uniqKey="Quinn P" first="P." last="Quinn">P. Quinn</name></author><author><name sortKey="Larkin, C" sort="Larkin, C" uniqKey="Larkin C" first="C." last="Larkin">C. Larkin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cluain Mhuire family cent.</s1><s2>Blackrock</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Cluain Mhuire family cent.</wicri:noRegion></affiliation></author><author><name sortKey="Oxford, J" sort="Oxford, J" uniqKey="Oxford J" first="J." last="Oxford">J. Oxford</name></author><author><name sortKey="Murray, R M" sort="Murray, R M" uniqKey="Murray R" first="R. M." last="Murray">R. M. Murray</name></author><author><name sortKey="O Callaghan, E" sort="O Callaghan, E" uniqKey="O Callaghan E" first="E." last="O'Callaghan">E. O'Callaghan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cluain Mhuire family cent.</s1><s2>Blackrock</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Cluain Mhuire family cent.</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">95-0481912</idno><date when="1995">1995</date><idno type="stanalyst">PASCAL 95-0481912 INIST</idno><idno type="RBID">Pascal:95-0481912</idno><idno type="wicri:Area/PascalFrancis/Corpus">000089</idno><idno type="wicri:Area/PascalFrancis/Curation">000125</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000091</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000091</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus ?</title><author><name sortKey="Cotter, D" sort="Cotter, D" uniqKey="Cotter D" first="D." last="Cotter">D. Cotter</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cluain Mhuire family cent.</s1><s2>Blackrock</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Cluain Mhuire family cent.</wicri:noRegion></affiliation></author><author><name sortKey="Takei, N" sort="Takei, N" uniqKey="Takei N" first="N." last="Takei">N. Takei</name></author><author><name sortKey="Farrell, M" sort="Farrell, M" uniqKey="Farrell M" first="M." last="Farrell">M. Farrell</name></author><author><name sortKey="Pak Sham" sort="Pak Sham" uniqKey="Pak Sham" last="Pak Sham">PAK SHAM</name></author><author><name sortKey="Quinn, P" sort="Quinn, P" uniqKey="Quinn P" first="P." last="Quinn">P. Quinn</name></author><author><name sortKey="Larkin, C" sort="Larkin, C" uniqKey="Larkin C" first="C." last="Larkin">C. Larkin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cluain Mhuire family cent.</s1><s2>Blackrock</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Cluain Mhuire family cent.</wicri:noRegion></affiliation></author><author><name sortKey="Oxford, J" sort="Oxford, J" uniqKey="Oxford J" first="J." last="Oxford">J. Oxford</name></author><author><name sortKey="Murray, R M" sort="Murray, R M" uniqKey="Murray R" first="R. M." last="Murray">R. M. Murray</name></author><author><name sortKey="O Callaghan, E" sort="O Callaghan, E" uniqKey="O Callaghan E" first="E." last="O'Callaghan">E. O'Callaghan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cluain Mhuire family cent.</s1><s2>Blackrock</s2><s3>IRL</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Cluain Mhuire family cent.</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Schizophrenia research</title><title level="j" type="abbreviated">Schizophr. res.</title><idno type="ISSN">0920-9964</idno><imprint><date when="1995">1995</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Schizophrenia research</title><title level="j" type="abbreviated">Schizophr. res.</title><idno type="ISSN">0920-9964</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term><term>Central nervous system disease</term><term>Cerebral disorder</term><term>Developmental disorder</term><term>Dorsal hippocampus</term><term>Etiology</term><term>Influenza</term><term>Mouse</term><term>Nervous system diseases</term><term>Pregnancy</term><term>Psychosis</term><term>Pyramidal neuron</term><term>Risk factor</term><term>Schizophrenia</term><term>Second trimester</term><term>Vulnerability</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Grippe</term><term>Gestation</term><term>Deuxième trimestre</term><term>Facteur risque</term><term>Trouble développement</term><term>Neurone pyramidal</term><term>Hippocampe dorsal</term><term>Encéphale pathologie</term><term>Système nerveux central pathologie</term><term>Système nerveux pathologie</term><term>Souris</term><term>Modèle animal</term><term>Vulnérabilité</term><term>Etiologie</term><term>Schizophrénie</term><term>Psychose</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9-16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0920-9964</s0></fA01><fA03 i2="1"><s0>Schizophr. res.</s0></fA03><fA05><s2>16</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus ?</s1></fA08><fA11 i1="01" i2="1"><s1>COTTER (D.)</s1></fA11><fA11 i1="02" i2="1"><s1>TAKEI (N.)</s1></fA11><fA11 i1="03" i2="1"><s1>FARRELL (M.)</s1></fA11><fA11 i1="04" i2="1"><s1>PAK SHAM</s1></fA11><fA11 i1="05" i2="1"><s1>QUINN (P.)</s1></fA11><fA11 i1="06" i2="1"><s1>LARKIN (C.)</s1></fA11><fA11 i1="07" i2="1"><s1>OXFORD (J.)</s1></fA11><fA11 i1="08" i2="1"><s1>MURRAY (R. 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Farrell</name><name sortKey="Murray, R M" sort="Murray, R M" uniqKey="Murray R" first="R. M." last="Murray">R. M. Murray</name><name sortKey="Oxford, J" sort="Oxford, J" uniqKey="Oxford J" first="J." last="Oxford">J. Oxford</name><name sortKey="Pak Sham" sort="Pak Sham" uniqKey="Pak Sham" last="Pak Sham">PAK SHAM</name><name sortKey="Quinn, P" sort="Quinn, P" uniqKey="Quinn P" first="P." last="Quinn">P. Quinn</name><name sortKey="Takei, N" sort="Takei, N" uniqKey="Takei N" first="N." last="Takei">N. Takei</name></noCountry><country name="Irlande (pays)"><noRegion><name sortKey="Cotter, D" sort="Cotter, D" uniqKey="Cotter D" first="D." last="Cotter">D. Cotter</name></noRegion><name sortKey="Larkin, C" sort="Larkin, C" uniqKey="Larkin C" first="C." last="Larkin">C. Larkin</name><name sortKey="O Callaghan, E" sort="O Callaghan, E" uniqKey="O Callaghan E" first="E." last="O'Callaghan">E. 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