Favipiravir, an anti-influenza drug against life-threatening RNA virus infections
Identifieur interne : 001049 ( Ncbi/Merge ); précédent : 001048; suivant : 001050Favipiravir, an anti-influenza drug against life-threatening RNA virus infections
Auteurs : Kimiyasu Shiraki [Japon] ; Tohru Daikoku [Japon]Source :
- Pharmacology & Therapeutics [ 0163-7258 ] ; 2020.
Abstract
Favipiravir has been developed as an anti-influenza drug and licensed as an anti-influenza drug in Japan. Additionally, favipiravir is being stockpiled for 2 million people as a countermeasure for novel influenza strains. This drug functions as a chain terminator at the site of incorporation of the viral RNA and reduces the viral load. Favipiravir cures all mice in a lethal influenza infection model, while oseltamivir fails to cure the animals. Thus, favipiravir contributes to curing animals with lethal infection. In addition to influenza, favipiravir has a broad spectrum of anti-RNA virus activities in vitro and efficacies in animal models with lethal RNA viruses and has been used for treatment of human infection with life-threatening Ebola virus, Lassa virus, rabies, and severe fever with thrombocytopenia syndrome. The best feature of favipiravir as an antiviral agent is the apparent lack of generation of favipiravir-resistant viruses. Favipiravir alone maintains its therapeutic efficacy from the first to the last patient in an influenza pandemic or an epidemic lethal RNA virus infection. Favipiravir is expected to be an important therapeutic agent for severe influenza, the next pandemic influenza strain, and other severe RNA virus infections for which standard treatments are not available.
Url:
DOI: 10.1016/j.pharmthera.2020.107512
PubMed: 32097670
PubMed Central: 7102570
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Favipiravir, an anti-influenza drug against life-threatening RNA virus infections</title><author><name sortKey="Shiraki, Kimiyasu" sort="Shiraki, Kimiyasu" uniqKey="Shiraki K" first="Kimiyasu" last="Shiraki">Kimiyasu Shiraki</name><affiliation wicri:level="1"><nlm:aff id="af0005">Senri Kinran University and Department of Virology, University of Toyama, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Senri Kinran University and Department of Virology, University of Toyama</wicri:regionArea><wicri:noRegion>University of Toyama</wicri:noRegion></affiliation></author><author><name sortKey="Daikoku, Tohru" sort="Daikoku, Tohru" uniqKey="Daikoku T" first="Tohru" last="Daikoku">Tohru Daikoku</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Microbiology, Faculty of Pharmaceutical Sciences, Hokuriku University, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology, Faculty of Pharmaceutical Sciences, Hokuriku University</wicri:regionArea><wicri:noRegion>Hokuriku University</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32097670</idno><idno type="pmc">7102570</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102570</idno><idno type="RBID">PMC:7102570</idno><idno type="doi">10.1016/j.pharmthera.2020.107512</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000C20</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C20</idno><idno type="wicri:Area/Pmc/Curation">000C20</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C20</idno><idno type="wicri:Area/Pmc/Checkpoint">000008</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000008</idno><idno type="wicri:Area/Ncbi/Merge">001049</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Favipiravir, an anti-influenza drug against life-threatening RNA virus infections</title><author><name sortKey="Shiraki, Kimiyasu" sort="Shiraki, Kimiyasu" uniqKey="Shiraki K" first="Kimiyasu" last="Shiraki">Kimiyasu Shiraki</name><affiliation wicri:level="1"><nlm:aff id="af0005">Senri Kinran University and Department of Virology, University of Toyama, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Senri Kinran University and Department of Virology, University of Toyama</wicri:regionArea><wicri:noRegion>University of Toyama</wicri:noRegion></affiliation></author><author><name sortKey="Daikoku, Tohru" sort="Daikoku, Tohru" uniqKey="Daikoku T" first="Tohru" last="Daikoku">Tohru Daikoku</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Microbiology, Faculty of Pharmaceutical Sciences, Hokuriku University, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology, Faculty of Pharmaceutical Sciences, Hokuriku University</wicri:regionArea><wicri:noRegion>Hokuriku University</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pharmacology & Therapeutics</title><idno type="ISSN">0163-7258</idno><idno type="eISSN">1879-016X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Favipiravir has been developed as an anti-influenza drug and licensed as an anti-influenza drug in Japan. Additionally, favipiravir is being stockpiled for 2 million people as a countermeasure for novel influenza strains. This drug functions as a chain terminator at the site of incorporation of the viral RNA and reduces the viral load. Favipiravir cures all mice in a lethal influenza infection model, while oseltamivir fails to cure the animals. Thus, favipiravir contributes to curing animals with lethal infection. In addition to influenza, favipiravir has a broad spectrum of anti-RNA virus activities in vitro and efficacies in animal models with lethal RNA viruses and has been used for treatment of human infection with life-threatening Ebola virus, Lassa virus, rabies, and severe fever with thrombocytopenia syndrome. The best feature of favipiravir as an antiviral agent is the apparent lack of generation of favipiravir-resistant viruses. Favipiravir alone maintains its therapeutic efficacy from the first to the last patient in an influenza pandemic or an epidemic lethal RNA virus infection. Favipiravir is expected to be an important therapeutic agent for severe influenza, the next pandemic influenza strain, and other severe RNA virus infections for which standard treatments are not available.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abdelnabi, R" uniqKey="Abdelnabi R">R. Abdelnabi</name></author><author><name sortKey="Jochmans, D" uniqKey="Jochmans D">D. Jochmans</name></author><author><name sortKey="Verbeken, E" uniqKey="Verbeken E">E. Verbeken</name></author><author><name sortKey="Neyts, J" uniqKey="Neyts J">J. Neyts</name></author><author><name sortKey="Delang, L" uniqKey="Delang L">L. Delang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abdelnabi, R" uniqKey="Abdelnabi R">R. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Pharmacol Ther</journal-id><journal-id journal-id-type="iso-abbrev">Pharmacol. Ther</journal-id><journal-title-group><journal-title>Pharmacology & Therapeutics</journal-title></journal-title-group><issn pub-type="ppub">0163-7258</issn><issn pub-type="epub">1879-016X</issn><publisher><publisher-name>Elsevier Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32097670</article-id><article-id pub-id-type="pmc">7102570</article-id><article-id pub-id-type="publisher-id">S0163-7258(20)30040-1</article-id><article-id pub-id-type="doi">10.1016/j.pharmthera.2020.107512</article-id><article-id pub-id-type="publisher-id">107512</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Favipiravir, an anti-influenza drug against life-threatening RNA virus infections</article-title></title-group><contrib-group><contrib contrib-type="author" id="au0005"><name><surname>Shiraki</surname><given-names>Kimiyasu</given-names></name><email>k-shiraki@cs.kinran.ac.jp</email><xref rid="af0005" ref-type="aff">a</xref><xref rid="cr0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="au0010"><name><surname>Daikoku</surname><given-names>Tohru</given-names></name><xref rid="af0010" ref-type="aff">b</xref></contrib></contrib-group><aff id="af0005"><label>a</label>Senri Kinran University and Department of Virology, University of Toyama, Japan</aff><aff id="af0010"><label>b</label>Department of Microbiology, Faculty of Pharmaceutical Sciences, Hokuriku University, Japan</aff><author-notes><corresp id="cr0005"><label>⁎</label>Corresponding author at: Senri Kinran University, 5-25-1 Fujishirodai, Suita, Osaka 565-0873, Japan. <email>k-shiraki@cs.kinran.ac.jp</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>22</day><month>2</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>22</day><month>2</month><year>2020</year></pub-date><elocation-id>107512</elocation-id><permissions><copyright-statement>© 2020 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ab0005"><p>Favipiravir has been developed as an anti-influenza drug and licensed as an anti-influenza drug in Japan. Additionally, favipiravir is being stockpiled for 2 million people as a countermeasure for novel influenza strains. This drug functions as a chain terminator at the site of incorporation of the viral RNA and reduces the viral load. Favipiravir cures all mice in a lethal influenza infection model, while oseltamivir fails to cure the animals. Thus, favipiravir contributes to curing animals with lethal infection. In addition to influenza, favipiravir has a broad spectrum of anti-RNA virus activities in vitro and efficacies in animal models with lethal RNA viruses and has been used for treatment of human infection with life-threatening Ebola virus, Lassa virus, rabies, and severe fever with thrombocytopenia syndrome. The best feature of favipiravir as an antiviral agent is the apparent lack of generation of favipiravir-resistant viruses. Favipiravir alone maintains its therapeutic efficacy from the first to the last patient in an influenza pandemic or an epidemic lethal RNA virus infection. Favipiravir is expected to be an important therapeutic agent for severe influenza, the next pandemic influenza strain, and other severe RNA virus infections for which standard treatments are not available.</p></abstract><kwd-group id="ks0005"><title>Keywords</title><kwd>Favipiravir</kwd><kwd>Influenza</kwd><kwd>Antiviral agent</kwd><kwd>Ebola</kwd><kwd>Chain termination</kwd><kwd>Resistant virus</kwd></kwd-group><kwd-group id="ks0010"><title>Abbreviations</title><kwd>baloxavir, baloxavir marboxil</kwd><kwd>G-string, guanosine homopolymeric string</kwd><kwd>IFN, interferon</kwd><kwd>IL, interleukin</kwd><kwd>NA, neuraminidase</kwd><kwd>NAI, NA inhibitor</kwd><kwd>PEP, postexposure prophylaxis</kwd><kwd>RdRp, RNA-dependent RNA polymerase</kwd><kwd>RTP, 4-ribofuranosyl-5′-triphosphate</kwd><kwd>SFTS, severe fever with thrombocytopenia syndrome</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Shiraki, Kimiyasu" sort="Shiraki, Kimiyasu" uniqKey="Shiraki K" first="Kimiyasu" last="Shiraki">Kimiyasu Shiraki</name></noRegion><name sortKey="Daikoku, Tohru" sort="Daikoku, Tohru" uniqKey="Daikoku T" first="Tohru" last="Daikoku">Tohru Daikoku</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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