No evidence of antigenic seniority in hemagglutinin specific antibody responses after adjuvanted pandemic 2009 influenza vaccination
Identifieur interne : 001000 ( Ncbi/Merge ); précédent : 000F99; suivant : 001001No evidence of antigenic seniority in hemagglutinin specific antibody responses after adjuvanted pandemic 2009 influenza vaccination
Auteurs : Anders Madsen [Norvège] ; Linda Azimi [Norvège] ; Sarah Tete [Norvège] ; Fan Zhou [Norvège] ; Florian Krammer [États-Unis] ; Rebecca Jane Cox [Norvège] ; Ne Jul-Larsen [Norvège]Source :
- Vaccine: X [ 2590-1362 ] ; 2019.
Abstract
AS03-adjuvanted H1N1pdm09 vaccine elicited robust antibody responses. More antigenically experienced individuals had higher pre-vaccination HA stalk specific antibodies. AS03 adjuvanted H1N1pdm09 vaccine overcomes problems of antigenic seniority.
Url:
DOI: 10.1016/j.jvacx.2019.100029
PubMed: 31384744
PubMed Central: 6668305
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Jebsen Centre for Influenza Vaccine Research, Department of Clinical Science, University of Bergen, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>K.G. Jebsen Centre for Influenza Vaccine Research, Department of Clinical Science, University of Bergen</wicri:regionArea><wicri:noRegion>University of Bergen</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine: X</title><idno type="eISSN">2590-1362</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0005">AS03-adjuvanted H1N1pdm09 vaccine elicited robust antibody responses.</p></list-item><list-item id="o0010"><label>•</label><p id="p0010">More antigenically experienced individuals had higher pre-vaccination HA stalk specific antibodies.</p></list-item><list-item id="o0015"><label>•</label><p id="p0015">AS03 adjuvanted H1N1pdm09 vaccine overcomes problems of antigenic seniority.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Iuliano, A D" uniqKey="Iuliano A">A.D. Iuliano</name></author><author><name sortKey="Roguski, K M" uniqKey="Roguski K">K.M. Roguski</name></author><author><name sortKey="Chang, H H" uniqKey="Chang H">H.H. Chang</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Krammer, F" uniqKey="Krammer F">F. Krammer</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krammer, F" uniqKey="Krammer F">F. Krammer</name></author><author><name sortKey="Pica, N" uniqKey="Pica N">N. Pica</name></author><author><name sortKey="Hai, R" uniqKey="Hai R">R. Hai</name></author><author><name sortKey="Margine, I" uniqKey="Margine I">I. Margine</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, M S" uniqKey="Miller M">M.S. Miller</name></author><author><name sortKey="Gardner, T J" uniqKey="Gardner T">T.J. Gardner</name></author><author><name sortKey="Krammer, F" uniqKey="Krammer F">F. Krammer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hai, R" uniqKey="Hai R">R. Hai</name></author><author><name sortKey="Krammer, F" uniqKey="Krammer F">F. Krammer</name></author><author><name sortKey="Tan, G S" uniqKey="Tan G">G.S. Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moody, M A" uniqKey="Moody M">M.A. Moody</name></author><author><name sortKey="Zhang, R" uniqKey="Zhang R">R. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohmit, S E" uniqKey="Ohmit S">S.E. Ohmit</name></author><author><name sortKey="Petrie, J G" uniqKey="Petrie J">J.G. Petrie</name></author><author><name sortKey="Cross, R T" uniqKey="Cross R">R.T. Cross</name></author><author><name sortKey="Johnson, E" uniqKey="Johnson E">E. Johnson</name></author><author><name sortKey="Monto, A S" uniqKey="Monto A">A.S. Monto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tete, S M" uniqKey="Tete S">S.M. Tete</name></author><author><name sortKey="Krammer, F" uniqKey="Krammer F">F. Krammer</name></author><author><name sortKey="Lartey, S" uniqKey="Lartey S">S. Lartey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davenport, F M" uniqKey="Davenport F">F.M. Davenport</name></author><author><name sortKey="Hennessy, A V" uniqKey="Hennessy A">A.V. Hennessy</name></author><author><name sortKey="Francis, T" uniqKey="Francis T">T. Francis</name></author><author><name sortKey="Fabisch, P" uniqKey="Fabisch P">P. Fabisch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lessler, J" uniqKey="Lessler J">J. Lessler</name></author><author><name sortKey="Riley, S" uniqKey="Riley S">S. Riley</name></author><author><name sortKey="Read, J M" uniqKey="Read J">J.M. Read</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gostic, K M" uniqKey="Gostic K">K.M. Gostic</name></author><author><name sortKey="Ambrose, M" uniqKey="Ambrose M">M. Ambrose</name></author><author><name sortKey="Worobey, M" uniqKey="Worobey M">M. Worobey</name></author><author><name sortKey="Lloyd Smith, J O" uniqKey="Lloyd Smith J">J.O. Lloyd-Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gagnon, A" uniqKey="Gagnon A">A. Gagnon</name></author><author><name sortKey="Acosta, E" uniqKey="Acosta E">E. Acosta</name></author><author><name sortKey="Hallman, S" uniqKey="Hallman S">S. Hallman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madhun, A S" uniqKey="Madhun A">A.S. Madhun</name></author><author><name sortKey="Akselsen, P E" uniqKey="Akselsen P">P.E. Akselsen</name></author><author><name sortKey="Sjursen, H" uniqKey="Sjursen H">H. Sjursen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pedersen, G K" uniqKey="Pedersen G">G.K. Pedersen</name></author><author><name sortKey="Hoschler, K" uniqKey="Hoschler K">K. Höschler</name></author><author><name sortKey=" Ie Solbak, S M" uniqKey=" Ie Solbak S">S.M. Øie Solbak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rowe, T" uniqKey="Rowe T">T. Rowe</name></author><author><name sortKey="Abernathy, R A" uniqKey="Abernathy R">R.A. Abernathy</name></author><author><name sortKey="Hu Primmer, J" uniqKey="Hu Primmer J">J. Hu-Primmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobsen, H" uniqKey="Jacobsen H">H. Jacobsen</name></author><author><name sortKey="Rajendran, M" uniqKey="Rajendran M">M. Rajendran</name></author><author><name sortKey="Choi, A" uniqKey="Choi A">A. Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, W" uniqKey="He W">W. He</name></author><author><name sortKey="Tan, G S" uniqKey="Tan G">G.S. Tan</name></author><author><name sortKey="Mullarkey, C E" uniqKey="Mullarkey C">C.E. Mullarkey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bodewes, R" uniqKey="Bodewes R">R. Bodewes</name></author><author><name sortKey="De Mutsert, G" uniqKey="De Mutsert G">G. de Mutsert</name></author><author><name sortKey="Van Der Klis, F R M" uniqKey="Van Der Klis F">F.R.M. van der Klis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hobson, D" uniqKey="Hobson D">D. Hobson</name></author><author><name sortKey="Curry, R L" uniqKey="Curry R">R.L. Curry</name></author><author><name sortKey="Beare, A S" uniqKey="Beare A">A.S. Beare</name></author><author><name sortKey="Ward Gardner, A" uniqKey="Ward Gardner A">A. Ward-Gardner</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Veguilla, V" uniqKey="Veguilla V">V. Veguilla</name></author><author><name sortKey="Hancock, K" uniqKey="Hancock K">K. Hancock</name></author><author><name sortKey="Schiffer, J" uniqKey="Schiffer J">J. Schiffer</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mohn, K G I" uniqKey="Mohn K">K.G.I. Mohn</name></author><author><name sortKey="L Rum, B N" uniqKey="L Rum B">B.N. Lærum</name></author><author><name sortKey="Skrede, S" uniqKey="Skrede S">S. Skrede</name></author><author><name sortKey="Cox, R" uniqKey="Cox R">R. Cox</name></author><author><name sortKey="Dyrhol Riise, A M" uniqKey="Dyrhol Riise A">A.M. Dyrhol-Riise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcon, N" uniqKey="Garcon N">N. Garçon</name></author><author><name sortKey="Vaughn, D W" uniqKey="Vaughn D">D.W. Vaughn</name></author><author><name sortKey="Didierlaurent, A M" uniqKey="Didierlaurent A">A.M. Didierlaurent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morel, S" uniqKey="Morel S">S. Morel</name></author><author><name sortKey="Didierlaurent, A" uniqKey="Didierlaurent A">A. Didierlaurent</name></author><author><name sortKey="Bourguignon, P" uniqKey="Bourguignon P">P. Bourguignon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galson, J D" uniqKey="Galson J">J.D. Galson</name></author><author><name sortKey="Truck, J" uniqKey="Truck J">J. Trück</name></author><author><name sortKey="Kelly, D F" uniqKey="Kelly D">D.F. Kelly</name></author><author><name sortKey="Van Der Most, R" uniqKey="Van Der Most R">R. van der Most</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lartey, S" uniqKey="Lartey S">S. Lartey</name></author><author><name sortKey="Pathirana, R D" uniqKey="Pathirana R">R.D. Pathirana</name></author><author><name sortKey="Zhou, F" uniqKey="Zhou F">F. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nachbagauer, R" uniqKey="Nachbagauer R">R. Nachbagauer</name></author><author><name sortKey="Choi, A" uniqKey="Choi A">A. Choi</name></author><author><name sortKey="Izikson, R" uniqKey="Izikson R">R. Izikson</name></author><author><name sortKey="Cox, M M" uniqKey="Cox M">M.M. Cox</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author><author><name sortKey="Krammer, F" uniqKey="Krammer F">F. Krammer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, J K" uniqKey="Park J">J.K. Park</name></author><author><name sortKey="Han, A" uniqKey="Han A">A. Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monsalvo, A C" uniqKey="Monsalvo A">A.C. Monsalvo</name></author><author><name sortKey="Batalle, J P" uniqKey="Batalle J">J.P. Batalle</name></author><author><name sortKey="Lopez, M F" uniqKey="Lopez M">M.F. Lopez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldblatt, D" uniqKey="Goldblatt D">D. Goldblatt</name></author><author><name sortKey="Vaz, A R" uniqKey="Vaz A">A.R. Vaz</name></author><author><name sortKey="Miller, E" uniqKey="Miller E">E. Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, E" uniqKey="Miller E">E. Miller</name></author><author><name sortKey="Hoschler, K" uniqKey="Hoschler K">K. Hoschler</name></author><author><name sortKey="Hardelid, P" uniqKey="Hardelid P">P. Hardelid</name></author><author><name sortKey="Stanford, E" uniqKey="Stanford E">E. Stanford</name></author><author><name sortKey="Andrews, N" uniqKey="Andrews N">N. Andrews</name></author><author><name sortKey="Zambon, M" uniqKey="Zambon M">M. Zambon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hancock, K" uniqKey="Hancock K">K. Hancock</name></author><author><name sortKey="Veguilla, V" uniqKey="Veguilla V">V. Veguilla</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frasca, D" uniqKey="Frasca D">D. Frasca</name></author><author><name sortKey="Diaz, A" uniqKey="Diaz A">A. Diaz</name></author><author><name sortKey="Romero, M" uniqKey="Romero M">M. Romero</name></author><author><name sortKey="Landin, A M" uniqKey="Landin A">A.M. Landin</name></author><author><name sortKey="Blomberg, B B" uniqKey="Blomberg B">B.B. Blomberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skowronski, D M" uniqKey="Skowronski D">D.M. Skowronski</name></author><author><name sortKey="Tweed, S A" uniqKey="Tweed S">S.A. Tweed</name></author><author><name sortKey="De Serres, G" uniqKey="De Serres G">G. De Serres</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klein, S L" uniqKey="Klein S">S.L. Klein</name></author><author><name sortKey="Hodgson, A" uniqKey="Hodgson A">A. Hodgson</name></author><author><name sortKey="Robinson, D P" uniqKey="Robinson D">D.P. Robinson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Vaccine X</journal-id><journal-id journal-id-type="iso-abbrev">Vaccine X</journal-id><journal-title-group><journal-title>Vaccine: X</journal-title></journal-title-group><issn pub-type="epub">2590-1362</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31384744</article-id><article-id pub-id-type="pmc">6668305</article-id><article-id pub-id-type="publisher-id">S2590-1362(19)30030-0</article-id><article-id pub-id-type="doi">10.1016/j.jvacx.2019.100029</article-id><article-id pub-id-type="publisher-id">100029</article-id><article-categories><subj-group subj-group-type="heading"><subject>Regular paper</subject></subj-group></article-categories><title-group><article-title>No evidence of antigenic seniority in hemagglutinin specific antibody responses after adjuvanted pandemic 2009 influenza vaccination</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Madsen</surname><given-names>Anders</given-names></name><xref rid="af005" ref-type="aff">a</xref><xref rid="fn1" ref-type="fn">1</xref></contrib><contrib contrib-type="author"><name><surname>Azimi</surname><given-names>Linda</given-names></name><xref rid="af005" ref-type="aff">a</xref><xref rid="fn1" ref-type="fn">1</xref></contrib><contrib contrib-type="author"><name><surname>Tete</surname><given-names>Sarah</given-names></name><xref rid="af005" ref-type="aff">a</xref><xref rid="af010" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Fan</given-names></name><xref rid="af005" ref-type="aff">a</xref><xref rid="af010" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Krammer</surname><given-names>Florian</given-names></name><xref rid="af015" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Rebecca Jane</given-names></name><email>rebecca.cox@uib.no</email><xref rid="af005" ref-type="aff">a</xref><xref rid="af010" ref-type="aff">b</xref><xref rid="af020" ref-type="aff">d</xref><xref rid="cor1" ref-type="corresp">⁎</xref><xref rid="fn1" ref-type="fn">1</xref></contrib><contrib contrib-type="author"><name><surname>Jul-Larsen</surname><given-names>Åsne</given-names></name><xref rid="af005" ref-type="aff">a</xref><xref rid="af010" ref-type="aff">b</xref><xref rid="fn1" ref-type="fn">1</xref></contrib></contrib-group><aff id="af005"><label>a</label>Influenza Centre, Department of Clinical Science, University of Bergen, Norway</aff><aff id="af010"><label>b</label>K.G. Jebsen Centre for Influenza Vaccine Research, Department of Clinical Science, University of Bergen, Norway</aff><aff id="af015"><label>c</label>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA</aff><aff id="af020"><label>d</label>Department of Research and Development, Haukeland University Hospital, Bergen, Norway</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author at: Head of the Influenza Centre, Department of Clinical Science, University of Bergen, Laboratory Building, 5th Floor, Jonas Lies vei 87, N-5021 Bergen, Norway. <email>rebecca.cox@uib.no</email></corresp><fn id="fn1"><label>1</label><p id="np010">Authors contributed equally.</p></fn></author-notes><pub-date pub-type="pmc-release"><day>20</day><month>6</month><year>2019</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="collection"><day>09</day><month>8</month><year>2019</year></pub-date><pub-date pub-type="epub"><day>20</day><month>6</month><year>2019</year></pub-date><volume>2</volume><elocation-id>100029</elocation-id><history><date date-type="received"><day>29</day><month>10</month><year>2018</year></date><date date-type="rev-recd"><day>28</day><month>5</month><year>2019</year></date><date date-type="accepted"><day>3</day><month>6</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 The Authors</copyright-statement><copyright-year>2019</copyright-year><license license-type="CC BY" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).</license-p></license></permissions><abstract abstract-type="author-highlights" id="ab005"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0005">AS03-adjuvanted H1N1pdm09 vaccine elicited robust antibody responses.</p></list-item><list-item id="o0010"><label>•</label><p id="p0010">More antigenically experienced individuals had higher pre-vaccination HA stalk specific antibodies.</p></list-item><list-item id="o0015"><label>•</label><p id="p0015">AS03 adjuvanted H1N1pdm09 vaccine overcomes problems of antigenic seniority.</p></list-item></list></p></abstract><abstract id="ab010"><p>Influenza is a contagious respiratory illness caused by the influenza virus. The pandemic outbreak of influenza A H1N1 in 2009 (H1N1pdm09) gave us a unique opportunity to study humoral immune responses to a novel influenza vaccine strain. Here, we investigate how an individual’s previous encounter with different influenza subtypes influences the humoral response after pandemic vaccination in 2009.</p><p>We retrospectively chose and grouped 80 vaccinated healthcare workers (HCWs) based on their year of birth into 4 groups, reflecting which influenza subtype they were likely first exposed to during childhood. Pre- and 21 days post- vaccination sera were analyzed. We investigated antibodies to the major surface protein hemagglutinin (HA), and specifically antibodies binding to the conserved stalk domain of the HA-protein. Serological assays were used to assess the quantity and functionality of the influenza-specific antibodies, including virus neutralization and activation of natural killer (NK) cells involved in antibody-dependent cell-mediated cytotoxicity (ADCC).</p><p>The AS03-adjuvanted H1N1pdm09 vaccine elicited robust antibody responses in all groups of HCWs. We found that the more antigenically experienced individuals had higher pre-vaccination antibody-levels towards the stalk domain of the HA. We also demonstrated that despite their inferior pre-vaccination antibody levels, the younger individuals reached similar antibody levels as the older birth-cohorts after pandemic vaccination. Our findings are important for understanding the effect of AS03 adjuvant on the antibody response in individuals exposed to different influenza viruses during their early childhood years, which is crucial for developing vaccine strategies against influenza.</p></abstract><kwd-group id="kg005"><title>Keywords</title><kwd>Healthcare worker</kwd><kwd>Antigenic seniority</kwd><kwd>AS03</kwd><kwd>Pandemic vaccine</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Norvège</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="Norvège"><noRegion><name sortKey="Madsen, Anders" sort="Madsen, Anders" uniqKey="Madsen A" first="Anders" last="Madsen">Anders Madsen</name></noRegion><name sortKey="Azimi, Linda" sort="Azimi, Linda" uniqKey="Azimi L" first="Linda" last="Azimi">Linda Azimi</name><name sortKey="Cox, Rebecca Jane" sort="Cox, Rebecca Jane" uniqKey="Cox R" first="Rebecca Jane" last="Cox">Rebecca Jane Cox</name><name sortKey="Cox, Rebecca Jane" sort="Cox, Rebecca Jane" uniqKey="Cox R" first="Rebecca Jane" last="Cox">Rebecca Jane Cox</name><name sortKey="Cox, Rebecca Jane" sort="Cox, Rebecca Jane" uniqKey="Cox R" first="Rebecca Jane" last="Cox">Rebecca Jane Cox</name><name sortKey="Jul Larsen, Ne" sort="Jul Larsen, Ne" uniqKey="Jul Larsen " first=" Ne" last="Jul-Larsen"> Ne Jul-Larsen</name><name sortKey="Jul Larsen, Ne" sort="Jul Larsen, Ne" uniqKey="Jul Larsen " first=" Ne" last="Jul-Larsen"> Ne Jul-Larsen</name><name sortKey="Tete, Sarah" sort="Tete, Sarah" uniqKey="Tete S" first="Sarah" last="Tete">Sarah Tete</name><name sortKey="Tete, Sarah" sort="Tete, Sarah" uniqKey="Tete S" first="Sarah" last="Tete">Sarah Tete</name><name sortKey="Zhou, Fan" sort="Zhou, Fan" uniqKey="Zhou F" first="Fan" last="Zhou">Fan Zhou</name><name sortKey="Zhou, Fan" sort="Zhou, Fan" uniqKey="Zhou F" first="Fan" last="Zhou">Fan Zhou</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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