Avian Influenza A Virus Pandemic Preparedness and Vaccine Development
Identifieur interne : 000F01 ( Ncbi/Merge ); précédent : 000F00; suivant : 000F02Avian Influenza A Virus Pandemic Preparedness and Vaccine Development
Auteurs : Rory D. De Vries ; Sander Herfst ; Mathilde RichardSource :
- Vaccines [ 2076-393X ] ; 2018.
Abstract
Influenza A viruses can infect a wide range of hosts, creating opportunities for zoonotic transmission, i.e., transmission from animals to humans, and placing the human population at constant risk of potential pandemics. In the last hundred years, four influenza A virus pandemics have had a devastating effect, especially the 1918 influenza pandemic that took the lives of at least 40 million people. There is a constant risk that currently circulating avian influenza A viruses (e.g., H5N1, H7N9) will cause a new pandemic. Vaccines are the cornerstone in preparing for and combating potential pandemics. Despite exceptional advances in the design and development of (pre-)pandemic vaccines, there are still serious challenges to overcome, mainly caused by intrinsic characteristics of influenza A viruses: Rapid evolution and a broad host range combined with maintenance in animal reservoirs, making it near impossible to predict the nature and source of the next pandemic virus. Here, recent advances in the development of vaccination strategies to prepare against a pandemic virus coming from the avian reservoir will be discussed. Furthermore, remaining challenges will be addressed, setting the agenda for future research in the development of new vaccination strategies against potentially pandemic influenza A viruses.
Url:
DOI: 10.3390/vaccines6030046
PubMed: 30044370
PubMed Central: 6161001
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Avian Influenza A Virus Pandemic Preparedness and Vaccine Development</title><author><name sortKey="De Vries, Rory D" sort="De Vries, Rory D" uniqKey="De Vries R" first="Rory D." last="De Vries">Rory D. De Vries</name></author><author><name sortKey="Herfst, Sander" sort="Herfst, Sander" uniqKey="Herfst S" first="Sander" last="Herfst">Sander Herfst</name></author><author><name sortKey="Richard, Mathilde" sort="Richard, Mathilde" uniqKey="Richard M" first="Mathilde" last="Richard">Mathilde Richard</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30044370</idno><idno type="pmc">6161001</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161001</idno><idno type="RBID">PMC:6161001</idno><idno type="doi">10.3390/vaccines6030046</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000E23</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E23</idno><idno type="wicri:Area/Pmc/Curation">000E23</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E23</idno><idno type="wicri:Area/Pmc/Checkpoint">000167</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000167</idno><idno type="wicri:Area/Ncbi/Merge">000F01</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Avian Influenza A Virus Pandemic Preparedness and Vaccine Development</title><author><name sortKey="De Vries, Rory D" sort="De Vries, Rory D" uniqKey="De Vries R" first="Rory D." last="De Vries">Rory D. De Vries</name></author><author><name sortKey="Herfst, Sander" sort="Herfst, Sander" uniqKey="Herfst S" first="Sander" last="Herfst">Sander Herfst</name></author><author><name sortKey="Richard, Mathilde" sort="Richard, Mathilde" uniqKey="Richard M" first="Mathilde" last="Richard">Mathilde Richard</name></author></analytic><series><title level="j">Vaccines</title><idno type="eISSN">2076-393X</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza A viruses can infect a wide range of hosts, creating opportunities for zoonotic transmission, i.e., transmission from animals to humans, and placing the human population at constant risk of potential pandemics. In the last hundred years, four influenza A virus pandemics have had a devastating effect, especially the 1918 influenza pandemic that took the lives of at least 40 million people. There is a constant risk that currently circulating avian influenza A viruses (e.g., H5N1, H7N9) will cause a new pandemic. Vaccines are the cornerstone in preparing for and combating potential pandemics. Despite exceptional advances in the design and development of (pre-)pandemic vaccines, there are still serious challenges to overcome, mainly caused by intrinsic characteristics of influenza A viruses: Rapid evolution and a broad host range combined with maintenance in animal reservoirs, making it near impossible to predict the nature and source of the next pandemic virus. Here, recent advances in the development of vaccination strategies to prepare against a pandemic virus coming from the avian reservoir will be discussed. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Vaccines (Basel)</journal-id><journal-id journal-id-type="iso-abbrev">Vaccines (Basel)</journal-id><journal-id journal-id-type="publisher-id">vaccines</journal-id><journal-title-group><journal-title>Vaccines</journal-title></journal-title-group><issn pub-type="epub">2076-393X</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">30044370</article-id><article-id pub-id-type="pmc">6161001</article-id><article-id pub-id-type="doi">10.3390/vaccines6030046</article-id><article-id pub-id-type="publisher-id">vaccines-06-00046</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Avian Influenza A Virus Pandemic Preparedness and Vaccine Development</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-2817-0127</contrib-id><name><surname>de Vries</surname><given-names>Rory D.</given-names></name></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-9866-8903</contrib-id><name><surname>Herfst</surname><given-names>Sander</given-names></name><xref rid="c1-vaccines-06-00046" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Richard</surname><given-names>Mathilde</given-names></name></contrib></contrib-group><aff id="af1-vaccines-06-00046">Department of Viroscience, Erasmus MC, P.O. Box 2040, 3000CA Rotterdam, The Netherlands;<email>r.d.devries@erasmusmc.nl</email> (R.D.d.V.);<email>m.richard@erasmusmc.nl</email> (M.R.)</aff><author-notes><corresp id="c1-vaccines-06-00046"><label>*</label>Correspondence: <email>s.herfst@erasmusmc.nl</email>; Tel.: +31-10-7043161</corresp></author-notes><pub-date pub-type="epub"><day>25</day><month>7</month><year>2018</year></pub-date><pub-date pub-type="collection"><month>9</month><year>2018</year></pub-date><volume>6</volume><issue>3</issue><elocation-id>46</elocation-id><history><date date-type="received"><day>25</day><month>6</month><year>2018</year></date><date date-type="accepted"><day>21</day><month>7</month><year>2018</year></date></history><permissions><copyright-statement>© 2018 by the authors.</copyright-statement><copyright-year>2018</copyright-year><license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>Influenza A viruses can infect a wide range of hosts, creating opportunities for zoonotic transmission, i.e., transmission from animals to humans, and placing the human population at constant risk of potential pandemics. In the last hundred years, four influenza A virus pandemics have had a devastating effect, especially the 1918 influenza pandemic that took the lives of at least 40 million people. There is a constant risk that currently circulating avian influenza A viruses (e.g., H5N1, H7N9) will cause a new pandemic. Vaccines are the cornerstone in preparing for and combating potential pandemics. Despite exceptional advances in the design and development of (pre-)pandemic vaccines, there are still serious challenges to overcome, mainly caused by intrinsic characteristics of influenza A viruses: Rapid evolution and a broad host range combined with maintenance in animal reservoirs, making it near impossible to predict the nature and source of the next pandemic virus. Here, recent advances in the development of vaccination strategies to prepare against a pandemic virus coming from the avian reservoir will be discussed. Furthermore, remaining challenges will be addressed, setting the agenda for future research in the development of new vaccination strategies against potentially pandemic influenza A viruses.</p></abstract><kwd-group><kwd>avian influenza A virus</kwd><kwd>zoonosis</kwd><kwd>pandemic</kwd><kwd>vaccination</kwd></kwd-group></article-meta></front><floats-group><table-wrap id="vaccines-06-00046-t001" orientation="portrait" position="float"><object-id pub-id-type="pii">vaccines-06-00046-t001_Table 1</object-id><label>Table 1</label><caption><p>Advantages and disadvantages of various vaccination strategies.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Vaccine Platform</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Advantages</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Disadvantages</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">References</th></tr></thead><tbody><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Inactivated vaccines</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><list list-type="bullet"><list-item><p>Safe</p></list-item></list></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><list list-type="bullet"><list-item><p>Limited immunogenicity</p></list-item><list-item><p>Short-lasting immunity</p></list-item><list-item><p>Often multiple doses required</p></list-item><list-item><p>Poor induction cellular immunity</p></list-item></list></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B21-vaccines-06-00046" ref-type="bibr">21</xref>,<xref rid="B22-vaccines-06-00046" ref-type="bibr">22</xref>,<xref rid="B24-vaccines-06-00046" ref-type="bibr">24</xref>,<xref rid="B30-vaccines-06-00046" ref-type="bibr">30</xref>]</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Subunit vaccines</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><list list-type="bullet"><list-item><p>Safe</p></list-item><list-item><p>Selection of antigen possible</p></list-item></list></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><list list-type="bullet"><list-item><p>Limited immunogenicity</p></list-item><list-item><p>Short-lasting immunity</p></list-item><list-item><p>Poor induction cellular immunity</p></list-item></list></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B27-vaccines-06-00046" ref-type="bibr">27</xref>,<xref rid="B40-vaccines-06-00046" ref-type="bibr">40</xref>,<xref rid="B41-vaccines-06-00046" ref-type="bibr">41</xref>]</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Live attenuated vaccines</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><list list-type="bullet"><list-item><p>Present conformational epitopes</p></list-item><list-item><p>Single dose sufficient</p></list-item><list-item><p>Induction cellular immunity</p></list-item></list></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><list list-type="bullet"><list-item><p>Safety risk in immunocompromized</p></list-item><list-item><p>Reversion to wildtype possible</p></list-item><list-item><p>Interference by maternal antibodies</p></list-item></list></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B26-vaccines-06-00046" ref-type="bibr">26</xref>,<xref rid="B64-vaccines-06-00046" ref-type="bibr">64</xref>,<xref rid="B85-vaccines-06-00046" ref-type="bibr">85</xref>,<xref rid="B86-vaccines-06-00046" ref-type="bibr">86</xref>,<xref rid="B88-vaccines-06-00046" ref-type="bibr">88</xref>]</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Virus-like particles</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><list list-type="bullet"><list-item><p>Safe</p></list-item><list-item><p>Present conformational epitopes</p></list-item></list></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><list list-type="bullet"><list-item><p>Complicated production process</p></list-item></list></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B53-vaccines-06-00046" ref-type="bibr">53</xref>,<xref rid="B54-vaccines-06-00046" ref-type="bibr">54</xref>,<xref rid="B91-vaccines-06-00046" ref-type="bibr">91</xref>]</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">DNA vaccines</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><list list-type="bullet"><list-item><p>Present conformational epitopes</p></list-item><list-item><p>Selection of antigen possible</p></list-item><list-item><p>Induction cellular immunity</p></list-item><list-item><p>Effective in heterologous prime-boost</p></list-item></list></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><list list-type="bullet"><list-item><p>Often poorly protective when used exclusively</p></list-item></list></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B38-vaccines-06-00046" ref-type="bibr">38</xref>,<xref rid="B50-vaccines-06-00046" ref-type="bibr">50</xref>,<xref rid="B51-vaccines-06-00046" ref-type="bibr">51</xref>,<xref rid="B52-vaccines-06-00046" ref-type="bibr">52</xref>,<xref rid="B92-vaccines-06-00046" ref-type="bibr">92</xref>]</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Vector-based vaccines</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><list list-type="bullet"><list-item><p>Safe</p></list-item><list-item><p>Present conformational epitopes</p></list-item><list-item><p>Selection of antigen possible</p></list-item><list-item><p>Induction humoral and cellular immunity</p></list-item><list-item><p>Effective in heterologous prime-boost</p></list-item></list></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><list list-type="bullet"><list-item><p>Often multiple doses required</p></list-item><list-item><p>Interference by vector-specific immunity</p></list-item></list></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B55-vaccines-06-00046" ref-type="bibr">55</xref>,<xref rid="B94-vaccines-06-00046" ref-type="bibr">94</xref>,<xref rid="B96-vaccines-06-00046" ref-type="bibr">96</xref>,<xref rid="B99-vaccines-06-00046" ref-type="bibr">99</xref>,<xref rid="B101-vaccines-06-00046" ref-type="bibr">101</xref>]</td></tr></tbody></table></table-wrap></floats-group></pmc><affiliations><list></list><tree><noCountry><name sortKey="De Vries, Rory D" sort="De Vries, Rory D" uniqKey="De Vries R" first="Rory D." last="De Vries">Rory D. De Vries</name><name sortKey="Herfst, Sander" sort="Herfst, Sander" uniqKey="Herfst S" first="Sander" last="Herfst">Sander Herfst</name><name sortKey="Richard, Mathilde" sort="Richard, Mathilde" uniqKey="Richard M" first="Mathilde" last="Richard">Mathilde Richard</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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