DDX5 RNA Helicases: Emerging Roles in Viral Infection
Identifieur interne : 000E69 ( Ncbi/Merge ); précédent : 000E68; suivant : 000E70DDX5 RNA Helicases: Emerging Roles in Viral Infection
Auteurs : Wenyu Cheng ; Guohua Chen ; Huaijie Jia ; Xiaobing He ; Zhizhong JingSource :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2018.
Abstract
Asp-Glu-Ala-Asp (DEAD)-box polypeptide 5 (DDX5), also called p68, is a prototypical member of the large ATP-dependent RNA helicases family and is known to participate in all aspects of RNA metabolism ranging from transcription to translation, RNA decay, and miRNA processing. The roles of DDX5 in cell cycle regulation, tumorigenesis, apoptosis, cancer development, adipogenesis, Wnt-β-catenin signaling, and viral infection have been established. Several RNA viruses have been reported to hijack DDX5 to facilitate various steps of their replication cycles. Furthermore, DDX5 can be bounded by the viral proteins of some viruses with unknown functions. Interestingly, an antiviral function of DDX5 has been reported during hepatitis B virus and myxoma virus infection. Thus, the precise roles of this apparently multifaceted protein remain largely obscure. Here, we provide a rapid and critical overview of the structure and functions of DDX5 with a particular emphasis on its role during virus infection.
Url:
DOI: 10.3390/ijms19041122
PubMed: 29642538
PubMed Central: 5979547
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">DDX5 RNA Helicases: Emerging Roles in Viral Infection</title><author><name sortKey="Cheng, Wenyu" sort="Cheng, Wenyu" uniqKey="Cheng W" first="Wenyu" last="Cheng">Wenyu Cheng</name></author><author><name sortKey="Chen, Guohua" sort="Chen, Guohua" uniqKey="Chen G" first="Guohua" last="Chen">Guohua Chen</name></author><author><name sortKey="Jia, Huaijie" sort="Jia, Huaijie" uniqKey="Jia H" first="Huaijie" last="Jia">Huaijie Jia</name></author><author><name sortKey="He, Xiaobing" sort="He, Xiaobing" uniqKey="He X" first="Xiaobing" last="He">Xiaobing He</name></author><author><name sortKey="Jing, Zhizhong" sort="Jing, Zhizhong" uniqKey="Jing Z" first="Zhizhong" last="Jing">Zhizhong Jing</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29642538</idno><idno type="pmc">5979547</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979547</idno><idno type="RBID">PMC:5979547</idno><idno type="doi">10.3390/ijms19041122</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000D81</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D81</idno><idno type="wicri:Area/Pmc/Curation">000D81</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D81</idno><idno type="wicri:Area/Pmc/Checkpoint">000158</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000158</idno><idno type="wicri:Area/Ncbi/Merge">000E69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">DDX5 RNA Helicases: Emerging Roles in Viral Infection</title><author><name sortKey="Cheng, Wenyu" sort="Cheng, Wenyu" uniqKey="Cheng W" first="Wenyu" last="Cheng">Wenyu Cheng</name></author><author><name sortKey="Chen, Guohua" sort="Chen, Guohua" uniqKey="Chen G" first="Guohua" last="Chen">Guohua Chen</name></author><author><name sortKey="Jia, Huaijie" sort="Jia, Huaijie" uniqKey="Jia H" first="Huaijie" last="Jia">Huaijie Jia</name></author><author><name sortKey="He, Xiaobing" sort="He, Xiaobing" uniqKey="He X" first="Xiaobing" last="He">Xiaobing He</name></author><author><name sortKey="Jing, Zhizhong" sort="Jing, Zhizhong" uniqKey="Jing Z" first="Zhizhong" last="Jing">Zhizhong Jing</name></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Asp-Glu-Ala-Asp (DEAD)-box polypeptide 5 (DDX5), also called p68, is a prototypical member of the large ATP-dependent RNA helicases family and is known to participate in all aspects of RNA metabolism ranging from transcription to translation, RNA decay, and miRNA processing. The roles of DDX5 in cell cycle regulation, tumorigenesis, apoptosis, cancer development, adipogenesis, Wnt-β-catenin signaling, and viral infection have been established. Several RNA viruses have been reported to hijack DDX5 to facilitate various steps of their replication cycles. Furthermore, DDX5 can be bounded by the viral proteins of some viruses with unknown functions. Interestingly, an antiviral function of DDX5 has been reported during hepatitis B virus and myxoma virus infection. Thus, the precise roles of this apparently multifaceted protein remain largely obscure. Here, we provide a rapid and critical overview of the structure and functions of DDX5 with a particular emphasis on its role during virus infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lane, D P" uniqKey="Lane D">D.P. Lane</name></author><author><name sortKey="Hoeffler, W K" uniqKey="Hoeffler W">W.K. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Mol Sci</journal-id><journal-id journal-id-type="iso-abbrev">Int J Mol Sci</journal-id><journal-id journal-id-type="publisher-id">ijms</journal-id><journal-title-group><journal-title>International Journal of Molecular Sciences</journal-title></journal-title-group><issn pub-type="epub">1422-0067</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29642538</article-id><article-id pub-id-type="pmc">5979547</article-id><article-id pub-id-type="doi">10.3390/ijms19041122</article-id><article-id pub-id-type="publisher-id">ijms-19-01122</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>DDX5 RNA Helicases: Emerging Roles in Viral Infection</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Wenyu</given-names></name></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Guohua</given-names></name></contrib><contrib contrib-type="author"><name><surname>Jia</surname><given-names>Huaijie</given-names></name></contrib><contrib contrib-type="author"><name><surname>He</surname><given-names>Xiaobing</given-names></name></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-1171-7931</contrib-id><name><surname>Jing</surname><given-names>Zhizhong</given-names></name><xref rid="c1-ijms-19-01122" ref-type="corresp">*</xref></contrib></contrib-group><aff id="af1-ijms-19-01122">State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Agriculture Ministry, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China;<email>wenyucheng1989@163.com</email> (W.C.);<email>chengguohua78@163.com</email> (G.C.);<email>huaijiejia@163.com</email> (H.J.);<email>hexb835@163.com</email> (X.H.)</aff><author-notes><corresp id="c1-ijms-19-01122"><label>*</label>Correspondence: <email>jingzhizhong@caas.cn</email>; Tel.: +86-931-834-1979</corresp></author-notes><pub-date pub-type="epub"><day>09</day><month>4</month><year>2018</year></pub-date><pub-date pub-type="collection"><month>4</month><year>2018</year></pub-date><volume>19</volume><issue>4</issue><elocation-id>1122</elocation-id><history><date date-type="received"><day>17</day><month>2</month><year>2018</year></date><date date-type="accepted"><day>02</day><month>4</month><year>2018</year></date></history><permissions><copyright-statement>© 2018 by the authors.</copyright-statement><copyright-year>2018</copyright-year><license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>Asp-Glu-Ala-Asp (DEAD)-box polypeptide 5 (DDX5), also called p68, is a prototypical member of the large ATP-dependent RNA helicases family and is known to participate in all aspects of RNA metabolism ranging from transcription to translation, RNA decay, and miRNA processing. The roles of DDX5 in cell cycle regulation, tumorigenesis, apoptosis, cancer development, adipogenesis, Wnt-β-catenin signaling, and viral infection have been established. Several RNA viruses have been reported to hijack DDX5 to facilitate various steps of their replication cycles. Furthermore, DDX5 can be bounded by the viral proteins of some viruses with unknown functions. Interestingly, an antiviral function of DDX5 has been reported during hepatitis B virus and myxoma virus infection. Thus, the precise roles of this apparently multifaceted protein remain largely obscure. Here, we provide a rapid and critical overview of the structure and functions of DDX5 with a particular emphasis on its role during virus infection.</p></abstract><kwd-group><kwd>DDX5</kwd><kwd>RNA helicases</kwd><kwd>modular domain structure</kwd><kwd>viral replication</kwd><kwd>antiviral ability</kwd></kwd-group></article-meta></front><floats-group><fig id="ijms-19-01122-f001" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Scheme of DEAD-box polypeptide 5 (DDX5) core architecture and conserved motifs. A schematic representation of DDX5 showing its nine conserved motifs (Q, I, Ia, Ib, II, III, IV, V, and VI) and the corresponding conserved amino acid sequences of motifs are presented. RGS-RGG: Arg-Gly-Ser-Arg-Gly-Gly.</p></caption><graphic xlink:href="ijms-19-01122-g001"></graphic></fig><fig id="ijms-19-01122-f002" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Role of DDX5 and other cellular helicases in the HIV-1 gene expression. DDX5 interacts with HIV Rev and participates in splicing or export of Rev-dependent mRNAs. Other cellular helicases with known functions are involved in HIV mRNA transcription, nuclear export, and translation.</p></caption><graphic xlink:href="ijms-19-01122-g002"></graphic></fig><table-wrap id="ijms-19-01122-t001" orientation="portrait" position="float"><object-id pub-id-type="pii">ijms-19-01122-t001_Table 1</object-id><label>Table 1</label><caption><p>Overview of the role of DEAD box polypeptide 5 (DDX5) in virus infection.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Virus</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Viral Binding Protein</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Effect of DDX5 on Viral Replication</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Ref.</th></tr></thead><tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">SARS-CoV</td><td align="center" valign="middle" rowspan="1" colspan="1">nsp13</td><td align="center" valign="middle" rowspan="1" colspan="1">Enhances virus proliferation</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B16-ijms-19-01122" ref-type="bibr">16</xref>]</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">IBV-CoV</td><td align="center" valign="middle" rowspan="1" colspan="1">nsp13</td><td align="center" valign="middle" rowspan="1" colspan="1">Enhances virus proliferation</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B16-ijms-19-01122" ref-type="bibr">16</xref>]</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">HIV-1</td><td align="center" valign="middle" rowspan="1" colspan="1">Rev</td><td align="center" valign="middle" rowspan="1" colspan="1">Enhances the Rev-dependent RNA export</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B17-ijms-19-01122" ref-type="bibr">17</xref>]</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">HCV</td><td align="center" valign="middle" rowspan="1" colspan="1">NS5B</td><td align="center" valign="middle" rowspan="1" colspan="1">Required for transcription of viral RNA</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B18-ijms-19-01122" ref-type="bibr">18</xref>]</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">JEV</td><td align="center" valign="middle" rowspan="1" colspan="1">C, NS3 and NS5</td><td align="center" valign="middle" rowspan="1" colspan="1">Required for viral RNA replication</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B19-ijms-19-01122" ref-type="bibr">19</xref>]</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">PRRSV</td><td align="center" valign="middle" rowspan="1" colspan="1">nsp9</td><td align="center" valign="middle" rowspan="1" colspan="1">Required for viral replication</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B20-ijms-19-01122" ref-type="bibr">20</xref>]</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Influenza virus</td><td align="center" valign="middle" rowspan="1" colspan="1">NP</td><td align="center" valign="middle" rowspan="1" colspan="1">Required for viral replication</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B21-ijms-19-01122" ref-type="bibr">21</xref>]</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">EBV</td><td align="center" valign="middle" rowspan="1" colspan="1">EBNA2</td><td align="center" valign="middle" rowspan="1" colspan="1">Unknown</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B24-ijms-19-01122" ref-type="bibr">24</xref>]</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"><italic>Pestivirus</italic></td><td align="center" valign="middle" rowspan="1" colspan="1">N<sup>pro</sup></td><td align="center" valign="middle" rowspan="1" colspan="1">Unknown</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B25-ijms-19-01122" ref-type="bibr">25</xref>]</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Myxoma virus</td><td align="center" valign="middle" rowspan="1" colspan="1">Unknown</td><td align="center" valign="middle" rowspan="1" colspan="1">Inhibits viral replication</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B22-ijms-19-01122" ref-type="bibr">22</xref>]</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">HBV</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Unknown</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Inhibits viral replication</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B23-ijms-19-01122" ref-type="bibr">23</xref>]</td></tr></tbody></table><table-wrap-foot><fn><p>SARS-CoV: severe acute respiratory syndrome coronavirus; IBV-CoV: infectious bronchitis virus coronavirus; HIV-1: human immunodeficiency virus 1; HBV: hepatitis B virus; HCV: hepatitis C virus; JEV: japanese encephalitis virus; PRRSV: porcine reproductive and respiratory syndrome virus; EBV: Epstein-Barr virus; nsp: nonstructural protein; NP: nucleoprotein; EBNA2: Epstein–Barr virus nuclear antigen 2; N<sup>pro</sup>: N-terminal protease.</p></fn></table-wrap-foot></table-wrap><table-wrap id="ijms-19-01122-t002" orientation="portrait" position="float"><object-id pub-id-type="pii">ijms-19-01122-t002_Table 2</object-id><label>Table 2</label><caption><p>The effects on HCV RNA and particles after the knockdown of DDX5 in different cell lines.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Cell Lines</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">HCV Strains</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Effect on HCV RNA</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Effect on HCV Particles</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Ref.</th></tr></thead><tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">293</td><td align="center" valign="middle" rowspan="1" colspan="1">HCV-S1</td><td align="center" valign="middle" rowspan="1" colspan="1">Reduced</td><td align="center" valign="middle" rowspan="1" colspan="1">Unknown</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B18-ijms-19-01122" ref-type="bibr">18</xref>]</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Huh7.5</td><td align="center" valign="middle" rowspan="1" colspan="1">J6/JFH-1</td><td align="center" valign="middle" rowspan="1" colspan="1">Increased</td><td align="center" valign="middle" rowspan="1" colspan="1">Promotes a late step in viral replication</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B81-ijms-19-01122" ref-type="bibr">81</xref>]</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Huh-7-NS3-3′</td><td align="center" valign="middle" rowspan="1" colspan="1">Unknown</td><td align="center" valign="middle" rowspan="1" colspan="1">Reduced</td><td align="center" valign="middle" rowspan="1" colspan="1">Unknown</td><td align="center" valign="middle" rowspan="1" colspan="1">[<xref rid="B80-ijms-19-01122" ref-type="bibr">80</xref>]</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">RSc cells</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">HCV-JFH1</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Reduced</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Suppressed</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B78-ijms-19-01122" ref-type="bibr">78</xref>]</td></tr></tbody></table></table-wrap></floats-group></pmc><affiliations><list></list><tree><noCountry><name sortKey="Chen, Guohua" sort="Chen, Guohua" uniqKey="Chen G" first="Guohua" last="Chen">Guohua Chen</name><name sortKey="Cheng, Wenyu" sort="Cheng, Wenyu" uniqKey="Cheng W" first="Wenyu" last="Cheng">Wenyu Cheng</name><name sortKey="He, Xiaobing" sort="He, Xiaobing" uniqKey="He X" first="Xiaobing" last="He">Xiaobing He</name><name sortKey="Jia, Huaijie" sort="Jia, Huaijie" uniqKey="Jia H" first="Huaijie" last="Jia">Huaijie Jia</name><name sortKey="Jing, Zhizhong" sort="Jing, Zhizhong" uniqKey="Jing Z" first="Zhizhong" last="Jing">Zhizhong Jing</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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