H2N2V1, Ncbi, Merge, bibRecord, 000E38

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

Identifieur interne : 000E38 ( Ncbi/Merge ); précédent : 000E37; suivant : 000E39

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

Auteurs : D. Korenkov [Russie, Australie] ; T. H. O. Nguyen [Australie] ; I. Isakova-Sivak [Russie] ; T. Smolonogina [Russie] ; L. E. Brown [Australie] ; K. Kedzierska [Australie] ; L. Rudenko [Russie]

Source :

Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2018.

RBID : PMC:5893192

Abstract

ABSTRACT

Live attenuated influenza vaccines (LAIV) induce CD8⁺ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8⁺ T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an in vitro model.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893192

DOI: 10.1080/21645515.2017.1417713
PubMed: 29252117
PubMed Central: 5893192

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PMC:5893192

Le document en format XML

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 T cells more relevant to current infections</title>
<author><name sortKey="Korenkov, D" sort="Korenkov, D" uniqKey="Korenkov D" first="D." last="Korenkov">D. Korenkov</name>
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<author><name sortKey="Nguyen, T H O" sort="Nguyen, T H O" uniqKey="Nguyen T" first="T. H. O." last="Nguyen">T. H. O. Nguyen</name>
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 T cells more relevant to current infections</title>
<author><name sortKey="Korenkov, D" sort="Korenkov, D" uniqKey="Korenkov D" first="D." last="Korenkov">D. Korenkov</name>
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<country xml:lang="fr">Russie</country>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Nguyen, T H O" sort="Nguyen, T H O" uniqKey="Nguyen T" first="T. H. O." last="Nguyen">T. H. O. Nguyen</name>
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, Melbourne, VIC,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Isakova Sivak, I" sort="Isakova Sivak, I" uniqKey="Isakova Sivak I" first="I." last="Isakova-Sivak">I. Isakova-Sivak</name>
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, Saint Petersburg,<country>Russia</country>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<country xml:lang="fr">Russie</country>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Kedzierska, K" sort="Kedzierska, K" uniqKey="Kedzierska K" first="K." last="Kedzierska">K. Kedzierska</name>
<affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Department of Microbiology & Immunology, University of Melbourne, at The Peter Doherty Institute for Infection & Immunity</institution>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Rudenko, L" sort="Rudenko, L" uniqKey="Rudenko L" first="L." last="Rudenko">L. Rudenko</name>
<affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Department of Virology, Institute of Experimental Medicine</institution>
, Saint Petersburg,<country>Russia</country>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<series><title level="j">Human Vaccines & Immunotherapeutics</title>
<idno type="ISSN">2164-5515</idno>
<idno type="eISSN">2164-554X</idno>
<imprint><date when="2018">2018</date>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>Live attenuated influenza vaccines (LAIV) induce CD8<sup>+</sup>
 T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8<sup>+</sup>
 T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an <italic>in vitro</italic>
 model.</p>
</div>
</front>
</TEI>
<pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Vaccin Immunother</journal-id>
<journal-id journal-id-type="iso-abbrev">Hum Vaccin Immunother</journal-id>
<journal-id journal-id-type="publisher-id">KHVI</journal-id>
<journal-id journal-id-type="publisher-id">khvi20</journal-id>
<journal-title-group><journal-title>Human Vaccines & Immunotherapeutics</journal-title>
</journal-title-group>
<issn pub-type="ppub">2164-5515</issn>
<issn pub-type="epub">2164-554X</issn>
<publisher><publisher-name>Taylor & Francis</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">29252117</article-id>
<article-id pub-id-type="pmc">5893192</article-id>
<article-id pub-id-type="publisher-id">1417713</article-id>
<article-id pub-id-type="doi">10.1080/21645515.2017.1417713</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Short Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8<sup>+</sup>
 T cells more relevant to current infections</article-title>
<alt-title alt-title-type="running-authors">D. KORENKOV ET AL.</alt-title>
<alt-title alt-title-type="running-title">HUMAN VACCINES & IMMUNOTHERAPEUTICS</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Korenkov</surname>
<given-names>D.</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>a</sup>
</xref>
<xref ref-type="aff" rid="af0002"><sup>b</sup>
</xref>
<xref ref-type="corresp" rid="an0001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nguyen</surname>
<given-names>T. H. O.</given-names>
</name>
<xref ref-type="aff" rid="af0002"><sup>b</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="ORCID">0000-0002-2801-1508</contrib-id>
<name><surname>Isakova-Sivak</surname>
<given-names>I.</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smolonogina</surname>
<given-names>T.</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brown</surname>
<given-names>L. E.</given-names>
</name>
<xref ref-type="aff" rid="af0002"><sup>b</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kedzierska</surname>
<given-names>K.</given-names>
</name>
<xref ref-type="aff" rid="af0002"><sup>b</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rudenko</surname>
<given-names>L.</given-names>
</name>
<xref ref-type="aff" rid="af0001"><sup>a</sup>
</xref>
</contrib>
<aff id="af0001"><label>a</label>
<institution>Department of Virology, Institute of Experimental Medicine</institution>
, Saint Petersburg,<country>Russia</country>
</aff>
<aff id="af0002"><label>b</label>
<institution>Department of Microbiology & Immunology, University of Melbourne, at The Peter Doherty Institute for Infection & Immunity</institution>
, Melbourne, VIC,<country>Australia</country>
</aff>
</contrib-group>
<author-notes><corresp id="an0001"><bold>CONTACT</bold>
 D. Korenkov <email xlink:href="d.korenkov@gmail.com">d.korenkov@gmail.com</email>
</corresp>
<fn><p>Supplemental data for this article can be accessed on the <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1080/21645515.2017.1417713">publisher's website</ext-link>
.</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2018</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>1</month>
<year>2018</year>
</pub-date>
<volume>14</volume>
<issue>4</issue>
<fpage seq="22">941</fpage>
<lpage>946</lpage>
<history><date date-type="received"><day>18</day>
<month>10</month>
<year>2017</year>
</date>
<date date-type="rev-recd"><day>20</day>
<month>11</month>
<year>2017</year>
</date>
<date date-type="accepted"><day>8</day>
<month>12</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© 2018 Taylor & Francis</copyright-statement>
<copyright-year>2018</copyright-year>
<copyright-holder>Taylor & Francis</copyright-holder>
</permissions>
<self-uri content-type="pdf" xlink:href="khvi-14-04-1417713.pdf"></self-uri>
<abstract><title>ABSTRACT</title>
<p>Live attenuated influenza vaccines (LAIV) induce CD8<sup>+</sup>
 T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8<sup>+</sup>
 T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8+ T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an <italic>in vitro</italic>
 model.</p>
</abstract>
<kwd-group kwd-group-type="author"><title>KEYWORDS</title>
<kwd>Antigenic escape</kwd>
<kwd>influenza</kwd>
<kwd>LAIV</kwd>
<kwd>nucleoprotein</kwd>
<kwd>T cell epitope</kwd>
</kwd-group>
<funding-group><award-group><funding-source><named-content content-type="funder-name">Russian Science Foundation Grant</named-content>
</funding-source>
<award-id>14-15-00034</award-id>
</award-group>
<funding-statement>The study was supported by Russian Science Foundation Grant №14–15–00034.</funding-statement>
</funding-group>
<counts><fig-count count="2"></fig-count>
<table-count count="1"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="27"></ref-count>
<page-count count="6"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Australie</li>
<li>Russie</li>
</country>
</list>
<tree><country name="Russie"><noRegion><name sortKey="Korenkov, D" sort="Korenkov, D" uniqKey="Korenkov D" first="D." last="Korenkov">D. Korenkov</name>
</noRegion>
<name sortKey="Isakova Sivak, I" sort="Isakova Sivak, I" uniqKey="Isakova Sivak I" first="I." last="Isakova-Sivak">I. Isakova-Sivak</name>
<name sortKey="Rudenko, L" sort="Rudenko, L" uniqKey="Rudenko L" first="L." last="Rudenko">L. Rudenko</name>
<name sortKey="Smolonogina, T" sort="Smolonogina, T" uniqKey="Smolonogina T" first="T." last="Smolonogina">T. Smolonogina</name>
</country>
<country name="Australie"><noRegion><name sortKey="Korenkov, D" sort="Korenkov, D" uniqKey="Korenkov D" first="D." last="Korenkov">D. Korenkov</name>
</noRegion>
<name sortKey="Brown, L E" sort="Brown, L E" uniqKey="Brown L" first="L. E." last="Brown">L. E. Brown</name>
<name sortKey="Kedzierska, K" sort="Kedzierska, K" uniqKey="Kedzierska K" first="K." last="Kedzierska">K. Kedzierska</name>
<name sortKey="Nguyen, T H O" sort="Nguyen, T H O" uniqKey="Nguyen T" first="T. H. O." last="Nguyen">T. H. O. Nguyen</name>
</country>
</tree>
</affiliations>
</record>

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Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

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Abstract

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