[MECHANISMS OF ATTENUATION OF COLD-ADAPTED STRAIN A/KRASNO- DAR/101/35/59 (H2N2)].
Identifieur interne : 000C80 ( Ncbi/Merge ); précédent : 000C79; suivant : 000C81[MECHANISMS OF ATTENUATION OF COLD-ADAPTED STRAIN A/KRASNO- DAR/101/35/59 (H2N2)].
Auteurs : S G Markushin ; O A Svitich ; A R Kinkulkina ; I B Koptyaeva ; K V LisovskayaSource :
- Zhurnal mikrobiologii, epidemiologii, i immunobiologii [ 0372-9311 ]
Descripteurs français
- KwdFr :
- Adaptation physiologique (génétique), Animaux, Basse température, Embryon de poulet, Génotype, Humains, Interférons (biosynthèse), Mutation, Phénotype, Protéines virales non structurales (biosynthèse), Protéines virales non structurales (génétique), Réplication virale (génétique), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (pathogénicité), Sous-type H1N1 du virus de la grippe A (physiologie), Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (pathogénicité), Sous-type H2N2 du virus de la grippe A (physiologie).
- MESH :
- biosynthèse : Interférons, Protéines virales non structurales.
- génétique : Adaptation physiologique, Protéines virales non structurales, Réplication virale, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A.
- pathogénicité : Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A.
- physiologie : Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A.
- Animaux, Basse température, Embryon de poulet, Génotype, Humains, Mutation, Phénotype.
English descriptors
- KwdEn :
- Adaptation, Physiological (genetics), Animals, Chick Embryo, Cold Temperature, Genotype, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza A Virus, H1N1 Subtype (physiology), Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (pathogenicity), Influenza A Virus, H2N2 Subtype (physiology), Interferons (biosynthesis), Mutation, Phenotype, Viral Nonstructural Proteins (biosynthesis), Viral Nonstructural Proteins (genetics), Virus Replication (genetics).
- MESH :
- chemical , biosynthesis : Interferons, Viral Nonstructural Proteins.
- genetics : Adaptation, Physiological, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Viral Nonstructural Proteins, Virus Replication.
- pathogenicity : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype.
- physiology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype.
- Animals, Chick Embryo, Cold Temperature, Genotype, Humans, Mutation, Phenotype.
Abstract
Study of mechanisms of attenuation of cold-adapted (ca) influenza virus strain A/ Krasnodar/101/35/59 (H2N2), associated with disruption of NS1 protein functions.
PubMed: 27228671
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pubmed:27228671Le document en format XML
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last="Svitich">O A Svitich</name></author><author><name sortKey="Kinkulkina, A R" sort="Kinkulkina, A R" uniqKey="Kinkulkina A" first="A R" last="Kinkulkina">A R Kinkulkina</name></author><author><name sortKey="Koptyaeva, I B" sort="Koptyaeva, I B" uniqKey="Koptyaeva I" first="I B" last="Koptyaeva">I B Koptyaeva</name></author><author><name sortKey="Lisovskaya, K V" sort="Lisovskaya, K V" uniqKey="Lisovskaya K" first="K V" last="Lisovskaya">K V Lisovskaya</name></author></analytic><series><title level="j">Zhurnal mikrobiologii, epidemiologii, i immunobiologii</title><idno type="ISSN">0372-9311</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (genetics)</term><term>Animals</term><term>Chick Embryo</term><term>Cold Temperature</term><term>Genotype</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term><term>Influenza A Virus, H1N1 Subtype (physiology)</term><term>Influenza A Virus, H2N2 Subtype (genetics)</term><term>Influenza A Virus, H2N2 Subtype (pathogenicity)</term><term>Influenza A Virus, H2N2 Subtype (physiology)</term><term>Interferons (biosynthesis)</term><term>Mutation</term><term>Phenotype</term><term>Viral Nonstructural Proteins (biosynthesis)</term><term>Viral Nonstructural Proteins (genetics)</term><term>Virus Replication (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation physiologique (génétique)</term><term>Animaux</term><term>Basse température</term><term>Embryon de poulet</term><term>Génotype</term><term>Humains</term><term>Interférons (biosynthèse)</term><term>Mutation</term><term>Phénotype</term><term>Protéines virales non structurales (biosynthèse)</term><term>Protéines virales non structurales (génétique)</term><term>Réplication virale (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term><term>Sous-type H1N1 du virus de la grippe A (physiologie)</term><term>Sous-type H2N2 du virus de la grippe A (génétique)</term><term>Sous-type H2N2 du virus de la grippe A (pathogénicité)</term><term>Sous-type H2N2 du virus de la grippe A (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferons</term><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interférons</term><term>Protéines virales non structurales</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adaptation, Physiological</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Viral Nonstructural Proteins</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adaptation physiologique</term><term>Protéines virales non structurales</term><term>Réplication virale</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chick Embryo</term><term>Cold Temperature</term><term>Genotype</term><term>Humans</term><term>Mutation</term><term>Phenotype</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Basse température</term><term>Embryon de poulet</term><term>Génotype</term><term>Humains</term><term>Mutation</term><term>Phénotype</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Study of mechanisms of attenuation of cold-adapted (ca) influenza virus strain A/ Krasnodar/101/35/59 (H2N2), associated with disruption of NS1 protein functions.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27228671</PMID><DateCompleted><Year>2016</Year><Month>06</Month><Day>17</Day></DateCompleted><DateRevised><Year>2016</Year><Month>05</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0372-9311</ISSN><JournalIssue CitedMedium="Print"><Issue>2</Issue><PubDate><MedlineDate>2016 Mar-Apr</MedlineDate></PubDate></JournalIssue><Title>Zhurnal mikrobiologii, epidemiologii, i immunobiologii</Title><ISOAbbreviation>Zh. Mikrobiol. Epidemiol. Immunobiol.</ISOAbbreviation></Journal><ArticleTitle>[MECHANISMS OF ATTENUATION OF COLD-ADAPTED STRAIN A/KRASNO- DAR/101/35/59 (H2N2)].</ArticleTitle><Pagination><MedlinePgn>49-56</MedlinePgn></Pagination><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">Study of mechanisms of attenuation of cold-adapted (ca) influenza virus strain A/ Krasnodar/101/35/59 (H2N2), associated with disruption of NS1 protein functions.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Study of interferonogenic activity of ca strain A/Krasnodar/101/35/59 (H2N2), its parent variant A/Krasnodar/101/59 (H2N2), virulent strain A/WSN/33 (H1N1) and a number of single gene and multiple gene reassortants between these strains, obtained using reverse genetics, was carried out. Study of dynamics of IFNβ gene expression was carried out by using a methodical approach of RT-PCR in real time mode.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Inclusion of PB-1 gene of ca strain A/ Krasnodar/101/35/59 (H2N2) with reversion to wild type into genome composition of virulent strain A/WSN/33 (H1N1) does not result in a sharp change of interferonogenic activity of the reassortant. At the same time, similar inclusion of PB-1 gene of ca strain resulted in an incredible growth of interferonogenic activity of the reassortant. On the other hand, inclusion of NP-gene of wild type strain A/Krasnodar/101/59 (H2N2) into genome composition of the wild type strain A/WSN/33 did not differ by effect on interferonogenicity of the reassortant from inclusion of NP-gene of ca strain.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Both constellations of genes of parent variants and mutations localized in these genes could affect formation of attenuation phenotype of reassortants. The data obtained allow to assume possible mechanisms of attenuation of ca strains, associated with disruption.of NS gene function.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Markushin</LastName><ForeName>S G</ForeName><Initials>SG</Initials></Author><Author ValidYN="Y"><LastName>Svitich</LastName><ForeName>O A</ForeName><Initials>OA</Initials></Author><Author ValidYN="Y"><LastName>Kinkulkina</LastName><ForeName>A R</ForeName><Initials>AR</Initials></Author><Author ValidYN="Y"><LastName>Koptyaeva</LastName><ForeName>I B</ForeName><Initials>IB</Initials></Author><Author ValidYN="Y"><LastName>Lisovskaya</LastName><ForeName>K V</ForeName><Initials>KV</Initials></Author></AuthorList><Language>rus</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Zh Mikrobiol Epidemiol Immunobiol</MedlineTA><NlmUniqueID>0415217</NlmUniqueID><ISSNLinking>0372-9311</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C108309">NS protein, influenza virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017361">Viral Nonstructural Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>9008-11-1</RegistryNumber><NameOfSubstance UI="D007372">Interferons</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000222" MajorTopicYN="N">Adaptation, Physiological</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002642" MajorTopicYN="N">Chick Embryo</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003080" MajorTopicYN="N">Cold Temperature</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="Y">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053121" MajorTopicYN="N">Influenza A Virus, H2N2 Subtype</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007372" MajorTopicYN="N">Interferons</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017361" MajorTopicYN="N">Viral Nonstructural Proteins</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>5</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>5</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27228671</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Kinkulkina, A R" sort="Kinkulkina, A R" uniqKey="Kinkulkina A" first="A R" last="Kinkulkina">A R Kinkulkina</name><name sortKey="Koptyaeva, I B" sort="Koptyaeva, I B" uniqKey="Koptyaeva I" first="I B" last="Koptyaeva">I B Koptyaeva</name><name sortKey="Lisovskaya, K V" sort="Lisovskaya, K V" uniqKey="Lisovskaya K" first="K V" last="Lisovskaya">K V Lisovskaya</name><name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S G" last="Markushin">S G Markushin</name><name sortKey="Svitich, O A" sort="Svitich, O A" uniqKey="Svitich O" first="O A" last="Svitich">O A Svitich</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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