H2N2V1, Ncbi, Merge, bibRecord, 000A78

Characterization of an H4N2 Influenza Virus from Quails with a Multibasic Motif in the Hemagglutinin Cleavage Site

Identifieur interne : 000A78 ( Ncbi/Merge ); précédent : 000A77; suivant : 000A79

Characterization of an H4N2 Influenza Virus from Quails with a Multibasic Motif in the Hemagglutinin Cleavage Site

Auteurs : Sook-San Wong ; Sun-Woo Yoon [Corée du Sud] ; Mark Zanin ; Min-Suk Song ; Christine Oshansky ; Hassan Zaraket [Liban] ; Stephanie Sonnberg ; Adam Rubrum ; Patrick Seiler ; Angela Ferguson ; Scott Krauss ; Carol Cardona ; Richard J. Webby ; Beate Crossley

Source :

Virology [ 0042-6822 ] ; 2014.

RBID : PMC:4253870

Abstract

The cleavage motif in the hemagglutinin (HA) protein of highly pathogenic H5 and H7 subtypes of avian influenza viruses is characterized by a peptide insertion or a multibasic cleavage site (MBCS). Here, we isolated an H4N2 virus from quails (Quail/CA12) with two additional arginines in the HA cleavage site, PEKRRTR/G, forming an MBCS-like motif. Quail/CA12 is a reassortant virus with the HA and neuraminidase (NA) gene most similar to a duck-isolated H4N2 virus, PD/CA06 with a monobasic HA cleavage site. Quail/CA12 required exogenous trypsin for efficient growth in culture and caused no clinical illness in infected chickens. Quail/CA12 had high binding preference for α2,6-linked sialic acids and showed higher replication and transmission ability in chickens and quails than PD/CA06. Although the H4N2 virus remained low pathogenic, these data suggests that the acquisition of MBCS in the field is not restricted to H5 or H7 subtypes.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253870

DOI: 10.1016/j.virol.2014.07.048
PubMed: 25151061
PubMed Central: 4253870

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: 000785
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PMC:4253870

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characterization of an H4N2 Influenza Virus from Quails with a Multibasic Motif in the Hemagglutinin Cleavage Site</title>
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<wicri:noCountry code="subfield">Memphis TN</wicri:noCountry>
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<wicri:noCountry code="subfield">Memphis TN</wicri:noCountry>
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<author><name sortKey="Ferguson, Angela" sort="Ferguson, Angela" uniqKey="Ferguson A" first="Angela" last="Ferguson">Angela Ferguson</name>
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<wicri:noCountry code="subfield">Memphis TN</wicri:noCountry>
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<wicri:noCountry code="subfield">Memphis TN</wicri:noCountry>
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<author><name sortKey="Cardona, Carol" sort="Cardona, Carol" uniqKey="Cardona C" first="Carol" last="Cardona">Carol Cardona</name>
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<wicri:noCountry code="subfield">Memphis TN</wicri:noCountry>
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<author><name sortKey="Crossley, Beate" sort="Crossley, Beate" uniqKey="Crossley B" first="Beate" last="Crossley">Beate Crossley</name>
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<wicri:noCountry code="subfield">Davis</wicri:noCountry>
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<series><title level="j">Virology</title>
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<front><div type="abstract" xml:lang="en"><p id="P2">The cleavage motif in the hemagglutinin (HA) protein of highly pathogenic H5 and H7 subtypes of avian influenza viruses is characterized by a peptide insertion or a multibasic cleavage site (MBCS). Here, we isolated an H4N2 virus from quails (Quail/CA12) with two additional arginines in the HA cleavage site, PEK<bold>RR</bold>
TR/G, forming an MBCS-like motif. Quail/CA12 is a reassortant virus with the HA and neuraminidase (NA) gene most similar to a duck-isolated H4N2 virus, PD/CA06 with a monobasic HA cleavage site. Quail/CA12 required exogenous trypsin for efficient growth in culture and caused no clinical illness in infected chickens. Quail/CA12 had high binding preference for α2,6-linked sialic acids and showed higher replication and transmission ability in chickens and quails than PD/CA06. Although the H4N2 virus remained low pathogenic, these data suggests that the acquisition of MBCS in the field is not restricted to H5 or H7 subtypes.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">0110674</journal-id>
<journal-id journal-id-type="pubmed-jr-id">8015</journal-id>
<journal-id journal-id-type="nlm-ta">Virology</journal-id>
<journal-id journal-id-type="iso-abbrev">Virology</journal-id>
<journal-title-group><journal-title>Virology</journal-title>
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<article-id pub-id-type="manuscript">NIHMS619264</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Characterization of an H4N2 Influenza Virus from Quails with a Multibasic Motif in the Hemagglutinin Cleavage Site</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Wong</surname>
<given-names>Sook-San</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yoon</surname>
<given-names>Sun-Woo</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zanin</surname>
<given-names>Mark</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Song</surname>
<given-names>Min-Suk</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oshansky</surname>
<given-names>Christine</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zaraket</surname>
<given-names>Hassan</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sonnberg</surname>
<given-names>Stephanie</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rubrum</surname>
<given-names>Adam</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Seiler</surname>
<given-names>Patrick</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ferguson</surname>
<given-names>Angela</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Krauss</surname>
<given-names>Scott</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cardona</surname>
<given-names>Carol</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Webby</surname>
<given-names>Richard J.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Crossley</surname>
<given-names>Beate</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
St. Jude Children’s Research Hospital, Memphis TN</aff>
<aff id="A2"><label>2</label>
University of Minnesota</aff>
<aff id="A3"><label>3</label>
School of Veterinary Medicine, University of California, Davis</aff>
<aff id="A4"><label>4</label>
Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea</aff>
<aff id="A5"><label>5</label>
American University of Beirut, Lebanon</aff>
<author-notes><corresp id="FN1">Address correspondence to <email>Bcrossle@cahfs.ucdavis.edu</email>
, Tel: +1-530-752-8700, Fax: +1-530-752-6253</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>20</day>
<month>8</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>8</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>11</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>11</month>
<year>2015</year>
</pub-date>
<volume>0</volume>
<fpage>72</fpage>
<lpage>80</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.virol.2014.07.048</pmc-comment>
      <permissions><copyright-statement>© 2014 Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><p id="P2">The cleavage motif in the hemagglutinin (HA) protein of highly pathogenic H5 and H7 subtypes of avian influenza viruses is characterized by a peptide insertion or a multibasic cleavage site (MBCS). Here, we isolated an H4N2 virus from quails (Quail/CA12) with two additional arginines in the HA cleavage site, PEK<bold>RR</bold>
TR/G, forming an MBCS-like motif. Quail/CA12 is a reassortant virus with the HA and neuraminidase (NA) gene most similar to a duck-isolated H4N2 virus, PD/CA06 with a monobasic HA cleavage site. Quail/CA12 required exogenous trypsin for efficient growth in culture and caused no clinical illness in infected chickens. Quail/CA12 had high binding preference for α2,6-linked sialic acids and showed higher replication and transmission ability in chickens and quails than PD/CA06. Although the H4N2 virus remained low pathogenic, these data suggests that the acquisition of MBCS in the field is not restricted to H5 or H7 subtypes.</p>
</abstract>
<kwd-group><kwd>H4N2</kwd>
<kwd>low pathogenic avian influenza</kwd>
<kwd>outbreak</kwd>
<kwd>quail</kwd>
<kwd>multibasic cleavage site</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Corée du Sud</li>
<li>Liban</li>
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<name sortKey="Ferguson, Angela" sort="Ferguson, Angela" uniqKey="Ferguson A" first="Angela" last="Ferguson">Angela Ferguson</name>
<name sortKey="Krauss, Scott" sort="Krauss, Scott" uniqKey="Krauss S" first="Scott" last="Krauss">Scott Krauss</name>
<name sortKey="Oshansky, Christine" sort="Oshansky, Christine" uniqKey="Oshansky C" first="Christine" last="Oshansky">Christine Oshansky</name>
<name sortKey="Rubrum, Adam" sort="Rubrum, Adam" uniqKey="Rubrum A" first="Adam" last="Rubrum">Adam Rubrum</name>
<name sortKey="Seiler, Patrick" sort="Seiler, Patrick" uniqKey="Seiler P" first="Patrick" last="Seiler">Patrick Seiler</name>
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<name sortKey="Wong, Sook San" sort="Wong, Sook San" uniqKey="Wong S" first="Sook-San" last="Wong">Sook-San Wong</name>
<name sortKey="Zanin, Mark" sort="Zanin, Mark" uniqKey="Zanin M" first="Mark" last="Zanin">Mark Zanin</name>
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<country name="Corée du Sud"><noRegion><name sortKey="Yoon, Sun Woo" sort="Yoon, Sun Woo" uniqKey="Yoon S" first="Sun-Woo" last="Yoon">Sun-Woo Yoon</name>
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<country name="Liban"><noRegion><name sortKey="Zaraket, Hassan" sort="Zaraket, Hassan" uniqKey="Zaraket H" first="Hassan" last="Zaraket">Hassan Zaraket</name>
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{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     PMC:4253870
   |texte=   Characterization of an H4N2 Influenza Virus from Quails with a Multibasic Motif in the Hemagglutinin Cleavage Site
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:25151061" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration H2N2

Characterization of an H4N2 Influenza Virus from Quails with a Multibasic Motif in the Hemagglutinin Cleavage Site

Characterization of an H4N2 Influenza Virus from Quails with a Multibasic Motif in the Hemagglutinin Cleavage Site

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