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Emergence of a C-Terminal Seven-Amino-Acid Elongation of NS1 in Around 1950 Conferred a Minor Growth Advantage to Former Seasonal Influenza A Viruses

Identifieur interne : 000935 ( Ncbi/Merge ); précédent : 000934; suivant : 000936

Emergence of a C-Terminal Seven-Amino-Acid Elongation of NS1 in Around 1950 Conferred a Minor Growth Advantage to Former Seasonal Influenza A Viruses

Auteurs : Florens Lohrmann ; Ronald Dijkman ; Silke Stertz ; Volker Thiel ; Otto Haller ; Peter Staeheli ; Georg Kochs

Source :

Journal of Virology [ 0022-538X ] ; 2013.

RBID : PMC:3807286

Abstract

Influenza A viruses circulating in humans from ∼1950 to ∼1987 featured a nonstructural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation remained elusive. We observed that replication kinetics of the wild-type virus A/Hong Kong/01/68 (H3N2) and a mutant encoding a truncated NS1 were indistinguishable in most experimental systems. However, wild-type virus outcompeted the mutant during mixed infections, suggesting that the NS1 extension conferred minor growth advantages.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807286

DOI: 10.1128/JVI.01271-13
PubMed: 23926347
PubMed Central: 3807286

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PMC:3807286

Le document en format XML

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<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
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<front><div type="abstract" xml:lang="en"><p>Influenza A viruses circulating in humans from ∼1950 to ∼1987 featured a nonstructural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation remained elusive. We observed that replication kinetics of the wild-type virus A/Hong Kong/01/68 (H3N2) and a mutant encoding a truncated NS1 were indistinguishable in most experimental systems. However, wild-type virus outcompeted the mutant during mixed infections, suggesting that the NS1 extension conferred minor growth advantages.</p>
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<pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Virol</journal-id>
<journal-id journal-id-type="hwp">jvi</journal-id>
<journal-id journal-id-type="pmc">jvi</journal-id>
<journal-id journal-id-type="publisher-id">JVI</journal-id>
<journal-title-group><journal-title>Journal of Virology</journal-title>
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<issn pub-type="ppub">0022-538X</issn>
<issn pub-type="epub">1098-5514</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
<publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc>
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<article-id pub-id-type="pmc">3807286</article-id>
<article-id pub-id-type="publisher-id">01271-13</article-id>
<article-id pub-id-type="doi">10.1128/JVI.01271-13</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject>
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</article-categories>
<title-group><article-title>Emergence of a C-Terminal Seven-Amino-Acid Elongation of NS1 in Around 1950 Conferred a Minor Growth Advantage to Former Seasonal Influenza A Viruses</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lohrmann</surname>
<given-names>Florens</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
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<contrib contrib-type="author"><name><surname>Dijkman</surname>
<given-names>Ronald</given-names>
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<xref ref-type="aff" rid="aff2"><sup>b</sup>
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<contrib contrib-type="author"><name><surname>Stertz</surname>
<given-names>Silke</given-names>
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<xref ref-type="aff" rid="aff3"><sup>c</sup>
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<contrib contrib-type="author"><name><surname>Thiel</surname>
<given-names>Volker</given-names>
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<xref ref-type="aff" rid="aff2"><sup>b</sup>
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<contrib contrib-type="author"><name><surname>Haller</surname>
<given-names>Otto</given-names>
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<xref ref-type="aff" rid="aff1"><sup>a</sup>
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<contrib contrib-type="author"><name><surname>Staeheli</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
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</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Kochs</surname>
<given-names>Georg</given-names>
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<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
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<aff id="aff1">Institute for Virology, University Medical Center Freiburg, Freiburg, Germany<label>a</label>
</aff>
<aff id="aff2">Institute of Immunobiology, Kantonal Hospital St. Gallen, St. Gallen, Switzerland<label>b</label>
</aff>
<aff id="aff3">Institute of Medical Virology, University of Zurich, Zurich, Switzerland<label>c</label>
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<author-notes><corresp id="cor1">Address correspondence to Georg Kochs, <email>georg.kochs@uniklinik-freiburg.de</email>
.</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>10</month>
<year>2013</year>
</pub-date>
<volume>87</volume>
<issue>20</issue>
<fpage>11300</fpage>
<lpage>11303</lpage>
<history><date date-type="received"><day>10</day>
<month>5</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>31</day>
<month>7</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2013, American Society for Microbiology. All Rights Reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>American Society for Microbiology</copyright-holder>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zjv02013011300.pdf"></self-uri>
<abstract><p>Influenza A viruses circulating in humans from ∼1950 to ∼1987 featured a nonstructural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation remained elusive. We observed that replication kinetics of the wild-type virus A/Hong Kong/01/68 (H3N2) and a mutant encoding a truncated NS1 were indistinguishable in most experimental systems. However, wild-type virus outcompeted the mutant during mixed infections, suggesting that the NS1 extension conferred minor growth advantages.</p>
</abstract>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Dijkman, Ronald" sort="Dijkman, Ronald" uniqKey="Dijkman R" first="Ronald" last="Dijkman">Ronald Dijkman</name>
<name sortKey="Haller, Otto" sort="Haller, Otto" uniqKey="Haller O" first="Otto" last="Haller">Otto Haller</name>
<name sortKey="Kochs, Georg" sort="Kochs, Georg" uniqKey="Kochs G" first="Georg" last="Kochs">Georg Kochs</name>
<name sortKey="Lohrmann, Florens" sort="Lohrmann, Florens" uniqKey="Lohrmann F" first="Florens" last="Lohrmann">Florens Lohrmann</name>
<name sortKey="Staeheli, Peter" sort="Staeheli, Peter" uniqKey="Staeheli P" first="Peter" last="Staeheli">Peter Staeheli</name>
<name sortKey="Stertz, Silke" sort="Stertz, Silke" uniqKey="Stertz S" first="Silke" last="Stertz">Silke Stertz</name>
<name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name>
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Emergence of a C-Terminal Seven-Amino-Acid Elongation of NS1 in Around 1950 Conferred a Minor Growth Advantage to Former Seasonal Influenza A Viruses

Emergence of a C-Terminal Seven-Amino-Acid Elongation of NS1 in Around 1950 Conferred a Minor Growth Advantage to Former Seasonal Influenza A Viruses

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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