Novel Viral Vectored Vaccines for the Prevention of Influenza
Identifieur interne : 000784 ( Ncbi/Merge ); précédent : 000783; suivant : 000785Novel Viral Vectored Vaccines for the Prevention of Influenza
Auteurs : Teresa LambeSource :
- Molecular Medicine [ 1076-1551 ] ; 2012.
Abstract
Influenza represents a substantial global healthcare burden, with annual epidemics resulting in 3–5 million cases of severe illness with a significant associated mortality. In addition, the risk of a virulent and lethal influenza pandemic has generated widespread and warranted concern. Currently licensed influenza vaccines are limited in their ability to induce efficacious and long-lasting herd immunity. In addition, and as evidenced by the H1N1 pandemic in 2009, there can be a significant delay between the emergence of a pandemic influenza and an effective, antibody-inducing vaccine. There is, therefore, a continued need for new, efficacious vaccines conferring cross-clade protection—obviating the need for biannual reformulation of seasonal influenza vaccines. Development of such a vaccine would yield enormous health benefits to society and also greatly reduce the associated global healthcare burden. There are a number of alternative influenza vaccine technologies being assessed both preclinically and clinically. In this review we discuss viral vectored vaccines, either recombinant live-attenuated or replication-deficient viruses, which are current lead candidates for inducing efficacious and long-lasting immunity toward influenza viruses. These alternate influenza vaccines offer real promise to deliver viable alternatives to currently deployed vaccines and more importantly may confer long-lasting and universal protection against influenza viral infection.
Url:
DOI: 10.2119/molmed.2012.00147
PubMed: 22735755
PubMed Central: 3510293
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Novel Viral Vectored Vaccines for the Prevention of
Influenza</title><author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22735755</idno><idno type="pmc">3510293</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510293</idno><idno type="RBID">PMC:3510293</idno><idno type="doi">10.2119/molmed.2012.00147</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000236</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000236</idno><idno type="wicri:Area/Pmc/Curation">000236</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000236</idno><idno type="wicri:Area/Pmc/Checkpoint">000700</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000700</idno><idno type="wicri:Area/Ncbi/Merge">000784</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Novel Viral Vectored Vaccines for the Prevention of
Influenza</title><author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Molecular Medicine</title><idno type="ISSN">1076-1551</idno><idno type="eISSN">1528-3658</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza represents a substantial global healthcare burden, with annual
epidemics resulting in 3–5 million cases of severe illness with a significant
associated mortality. In addition, the risk of a virulent and lethal influenza
pandemic has generated widespread and warranted concern. Currently licensed
influenza vaccines are limited in their ability to induce efficacious and
long-lasting herd immunity. In addition, and as evidenced by the H1N1 pandemic in
2009, there can be a significant delay between the emergence of a pandemic influenza
and an effective, antibody-inducing vaccine. There is, therefore, a continued need
for new, efficacious vaccines conferring cross-clade protection—obviating the need
for biannual reformulation of seasonal influenza vaccines. Development of such a
vaccine would yield enormous health benefits to society and also greatly reduce the
associated global healthcare burden. There are a number of alternative influenza
vaccine technologies being assessed both preclinically and clinically. In this
review we discuss viral vectored vaccines, either recombinant live-attenuated or
replication-deficient viruses, which are current lead candidates for inducing
efficacious and long-lasting immunity toward influenza viruses. These alternate
influenza vaccines offer real promise to deliver viable alternatives to currently
deployed vaccines and more importantly may confer long-lasting and universal
protection against influenza viral infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Molinari, Na" uniqKey="Molinari N">NA Molinari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lambert, Lc" uniqKey="Lambert L">LC Lambert</name></author><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Np" uniqKey="Johnson N">NP Johnson</name></author><author><name sortKey="Mueller, J" uniqKey="Mueller J">J Mueller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Normile, D" uniqKey="Normile D">D Normile</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kovacova, A" uniqKey="Kovacova A">A Kovacova</name></author><author><name sortKey="Ruttkay Nedecky, G" uniqKey="Ruttkay Nedecky G">G Ruttkay-Nedecky</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Mol Med</journal-id><journal-id journal-id-type="iso-abbrev">Mol. Med</journal-id><journal-title-group><journal-title>Molecular Medicine</journal-title></journal-title-group><issn pub-type="ppub">1076-1551</issn><issn pub-type="epub">1528-3658</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22735755</article-id><article-id pub-id-type="pmc">3510293</article-id><article-id pub-id-type="publisher-id">18081153</article-id><article-id pub-id-type="doi">10.2119/molmed.2012.00147</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Novel Viral Vectored Vaccines for the Prevention of
Influenza</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Lambe</surname><given-names>Teresa</given-names></name><address><phone>+44-1865-617621</phone><fax>+44-1865-617608</fax><email>teresa.lambe@ndm.ox.ac.uk</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution>Jenner Institute,</institution><institution>University of Oxford,</institution></institution-wrap>Oxford, UK</aff></contrib-group><pub-date pub-type="epub"><day>19</day><month>6</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>19</day><month>6</month><year>2012</year></pub-date><pub-date pub-type="ppub"><year>2012</year></pub-date><volume>18</volume><fpage>1153</fpage><lpage>1160</lpage><history><date date-type="received"><day>29</day><month>3</month><year>2012</year></date><date date-type="accepted"><day>19</day><month>6</month><year>2012</year></date></history><permissions><copyright-statement>© The Author(s) 2012</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold> This article is licensed
under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
License, which permits any non-commercial use, sharing, distribution and
reproduction in any medium or format, as long as you give appropriate credit to
the original author(s) and the source, and provide a link to the Creative Commons
license. You do not have permission under this license to share adapted material
derived from this article or parts of it.</license-p><license-p>The images or other third party material in this article are included in
the article’s Creative Commons license, unless indicated otherwise in a credit
line to the material. If material is not included in the article’s Creative
Commons license and your intended use is not permitted by statutory regulation or
exceeds the permitted use, you will need to obtain permission directly from the
copyright holder.</license-p><license-p>To view a copy of this license, visit (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc-nd/4.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ext-link>)</license-p></license></permissions><abstract id="Abs1"><p>Influenza represents a substantial global healthcare burden, with annual
epidemics resulting in 3–5 million cases of severe illness with a significant
associated mortality. In addition, the risk of a virulent and lethal influenza
pandemic has generated widespread and warranted concern. Currently licensed
influenza vaccines are limited in their ability to induce efficacious and
long-lasting herd immunity. In addition, and as evidenced by the H1N1 pandemic in
2009, there can be a significant delay between the emergence of a pandemic influenza
and an effective, antibody-inducing vaccine. There is, therefore, a continued need
for new, efficacious vaccines conferring cross-clade protection—obviating the need
for biannual reformulation of seasonal influenza vaccines. Development of such a
vaccine would yield enormous health benefits to society and also greatly reduce the
associated global healthcare burden. There are a number of alternative influenza
vaccine technologies being assessed both preclinically and clinically. In this
review we discuss viral vectored vaccines, either recombinant live-attenuated or
replication-deficient viruses, which are current lead candidates for inducing
efficacious and long-lasting immunity toward influenza viruses. These alternate
influenza vaccines offer real promise to deliver viable alternatives to currently
deployed vaccines and more importantly may confer long-lasting and universal
protection against influenza viral infection.</p></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2012</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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