Mechanisms of sex disparities in influenza pathogenesis
Identifieur interne : 000716 ( Ncbi/Merge ); précédent : 000715; suivant : 000717Mechanisms of sex disparities in influenza pathogenesis
Auteurs : Sabra L. Klein [États-Unis] ; Andrea Hodgson ; Dionne P. RobinsonSource :
- Journal of Leukocyte Biology [ 0741-5400 ] ; 2012.
Abstract
Review on gender-associated immune responses to influenza viruses, which though protective following vaccination, can cause immunopathology following exposure to pathogenic viruses.
Url:
DOI: 10.1189/jlb.0811427
PubMed: 22131346
PubMed Central: 4046247
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Leukoc Biol</journal-id><journal-id journal-id-type="iso-abbrev">J. Leukoc. Biol</journal-id><journal-id journal-id-type="hwp">jleub</journal-id><journal-id journal-id-type="pmc">jleub</journal-id><journal-id journal-id-type="publisher-id">JLB</journal-id><journal-title-group><journal-title>Journal of Leukocyte Biology</journal-title></journal-title-group><issn pub-type="ppub">0741-5400</issn><issn pub-type="epub">1938-3673</issn><publisher><publisher-name>Society for Leukocyte Biology</publisher-name><publisher-loc>Bethesda, MD, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22131346</article-id><article-id pub-id-type="pmc">4046247</article-id><article-id pub-id-type="publisher-id">0811-427</article-id><article-id pub-id-type="doi">10.1189/jlb.0811427</article-id><article-categories><subj-group subj-group-type="heading"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Mechanisms of sex disparities in influenza pathogenesis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Klein</surname><given-names>Sabra L.</given-names></name><xref ref-type="aff" rid="aff1">*</xref><xref ref-type="aff" rid="aff2"><sup>†</sup></xref><xref ref-type="corresp" rid="cor1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hodgson</surname><given-names>Andrea</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Robinson</surname><given-names>Dionne P.</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><aff id="aff1"><label>*</label>The W. Harry Feinstone Department of Molecular Microbiology and Immunology and</aff><aff id="aff2"><label>†</label>Department of Biochemistry and Molecular Biology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</aff></contrib-group><author-notes><corresp id="cor1"><label>1.</label>Correspondence: <addr-line>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD 21205, USA.</addr-line> E-mail: <email>saklein@jhsph.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>7</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>92</volume><issue>1</issue><fpage>67</fpage><lpage>73</lpage><history><date date-type="received"><day>23</day><month>8</month><year>2011</year></date><date date-type="rev-recd"><day>4</day><month>10</month><year>2011</year></date><date date-type="accepted"><day>25</day><month>10</month><year>2011</year></date></history><permissions><copyright-statement>© 2012 Society for Leukocyte Biology</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zgb00712000067.pdf"></self-uri><abstract abstract-type="precis"><p>Review on gender-associated immune responses to influenza viruses, which though protective following vaccination, can cause immunopathology following exposure to pathogenic viruses.</p></abstract><abstract><p>Epidemiological evidence from influenza outbreaks and pandemics reveals that morbidity and mortality are often higher for women than men. Sex differences in the outcome of influenza are age-dependent, often being most pronounced among adults of reproductive ages (18–49 years of age) and sometimes reflecting the unique state of pregnancy in females, which is a risk factor for severe disease. Small animal models of influenza virus infection illustrate that inflammatory immune responses also differ between the sexes and impact the outcome of infection, with females generating higher proinflammatory cytokine and chemokine responses and experiencing greater morbidity and mortality than males. Males and females also respond differently to influenza vaccines, with women initiating higher humoral immune responses but experiencing more adverse reactions to seasonal influenza vaccines than men. Small animal models further show that elevated immunity following vaccination in females leads to greater cross-protection against novel influenza viruses in females compared with males. Sex steroid hormones, including estradiol and testosterone, as well as genetic differences between the sexes may play roles in modulating sex differences in immune responses to influenza virus infection and vaccination. Future studies must elucidate the pathways and cellular responses that differ between the sexes and determine how best to use this knowledge to inform public health policy-makers about prophylaxis and therapeutic treatments of influenza virus infections to ensure adequate protection in both males and females.</p></abstract><kwd-group><kwd>CCL2</kwd><kwd>estradiol</kwd><kwd>sex chromosome</kwd><kwd>sex difference</kwd><kwd>testosterone</kwd><kwd>TNF-α</kwd><kwd>vaccine</kwd></kwd-group><funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source><award-id rid="CS100">AI089034</award-id><award-id rid="CS100">AI079342</award-id><award-id rid="CS100">AI090344</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Hodgson, Andrea" sort="Hodgson, Andrea" uniqKey="Hodgson A" first="Andrea" last="Hodgson">Andrea Hodgson</name><name sortKey="Robinson, Dionne P" sort="Robinson, Dionne P" uniqKey="Robinson D" first="Dionne P." last="Robinson">Dionne P. Robinson</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Klein, Sabra L" sort="Klein, Sabra L" uniqKey="Klein S" first="Sabra L." last="Klein">Sabra L. Klein</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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