Novel vaccines against influenza viruses
Identifieur interne : 000694 ( Ncbi/Merge ); précédent : 000693; suivant : 000695Novel vaccines against influenza viruses
Auteurs : Sang-Moo Kang [États-Unis] ; Jae-Min Song ; Richard W. CompansSource :
- Virus Research [ 0168-1702 ] ; 2011.
Abstract
Killed and live attenuated influenza virus vaccines are effective in preventing and curbing the spread of influenza epidemics when the strains present in the vaccines are closely matched with the predicted epidemic strains. These vaccines are primarily targeted to induce immunity to the variable major target antigen, hemagglutinin (HA) of influenza virus. However, current vaccines are not effective in preventing the emergence of new pandemic or highly virulent viruses. New approaches are being investigated to develop universal influenza virus vaccines as well as to apply more effective vaccine delivery methods. Conserved vaccine targets including the influenza M2 ion channel protein and HA stalk domains are being developed using recombinant technologies to improve the level of cross protection. In addition, recent studies provide evidence that vaccine supplements can provide avenues to further improve current vaccination.
Url:
DOI: 10.1016/j.virusres.2011.09.037
PubMed: 21968298
PubMed Central: 3401575
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PMC:3401575Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P2">Killed and live attenuated influenza virus vaccines are effective in preventing and curbing the spread of influenza epidemics when the strains present in the vaccines are closely matched with the predicted epidemic strains. These vaccines are primarily targeted to induce immunity to the variable major target antigen, hemagglutinin (HA) of influenza virus. However, current vaccines are not effective in preventing the emergence of new pandemic or highly virulent viruses. New approaches are being investigated to develop universal influenza virus vaccines as well as to apply more effective vaccine delivery methods. Conserved vaccine targets including the influenza M2 ion channel protein and HA stalk domains are being developed using recombinant technologies to improve the level of cross protection. In addition, recent studies provide evidence that vaccine supplements can provide avenues to further improve current vaccination.</p>
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<contrib-group><contrib contrib-type="author"><name><surname>Kang</surname>
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<xref ref-type="aff" rid="A1">1</xref>
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<aff id="A1"><label>1</label>
Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, Georgia 30303</aff>
<aff id="A2"><label>2</label>
Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, 30322</aff>
<author-notes><corresp id="FN1"><label>*</label>
Corresponding authors: Center for Inflammation, Immunity & Infection (S.M.K.), Department of Biology, Georgia State University, 100 Piedmont Avenue, 7th Floor 718, Atlanta, Georgia 30303. Phone: 404-413-3588. Fax: 404-413-3580; <email>skang24@gsu.edu</email>
. Department of Microbiology and Immunology (R.W.C), Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322. Phone: 404-727-2015; Fax, 404-727-3295; <email>rcompan@emory.edu</email>
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<volume>162</volume>
<issue>1-2</issue>
<fpage>31</fpage>
<lpage>38</lpage>
<permissions><copyright-statement>© 2011 Elsevier B.V. All rights reserved.</copyright-statement>
<copyright-year>2011</copyright-year>
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<abstract><p id="P2">Killed and live attenuated influenza virus vaccines are effective in preventing and curbing the spread of influenza epidemics when the strains present in the vaccines are closely matched with the predicted epidemic strains. These vaccines are primarily targeted to induce immunity to the variable major target antigen, hemagglutinin (HA) of influenza virus. However, current vaccines are not effective in preventing the emergence of new pandemic or highly virulent viruses. New approaches are being investigated to develop universal influenza virus vaccines as well as to apply more effective vaccine delivery methods. Conserved vaccine targets including the influenza M2 ion channel protein and HA stalk domains are being developed using recombinant technologies to improve the level of cross protection. In addition, recent studies provide evidence that vaccine supplements can provide avenues to further improve current vaccination.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>R01 AI068003-05 || AI</award-id>
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<affiliations><list><country><li>États-Unis</li>
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