Meeting the Challenge of Influenza Pandemic Preparedness in Developing Countries
Identifieur interne : 000350 ( Ncbi/Merge ); précédent : 000349; suivant : 000351Meeting the Challenge of Influenza Pandemic Preparedness in Developing Countries
Auteurs : David S. FedsonSource :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2009.
Abstract
One-sentence summary for table of contents: These countries should consider using inexpensive generic agents to confront the next pandemic.
Url:
DOI: 10.3201/eid1503.080857
PubMed: 19239746
PubMed Central: 2681116
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Emerg Infect Dis</journal-id><journal-id journal-id-type="publisher-id">EID</journal-id><journal-title>Emerging Infectious Diseases</journal-title><issn pub-type="ppub">1080-6040</issn><issn pub-type="epub">1080-6059</issn><publisher><publisher-name>Centers for Disease Control and Prevention</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19239746</article-id><article-id pub-id-type="pmc">2681116</article-id><article-id pub-id-type="publisher-id">08-0857</article-id><article-id pub-id-type="doi">10.3201/eid1503.080857</article-id><article-categories><subj-group subj-group-type="heading"><subject>Perspective</subject></subj-group></article-categories><title-group><article-title>Meeting the Challenge of Influenza Pandemic Preparedness in Developing Countries </article-title><alt-title alt-title-type="running-head">Pandemic Preparedness in Developing Countries</alt-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Fedson</surname><given-names>David S.</given-names></name></contrib><aff id="aff1">University of Virginia, Charlottesville, Virginia, USA (retired)</aff></contrib-group><author-notes><corresp id="cor1">Address for correspondence: David S. Fedson, 57 Chemin du Lavoir, 01630 Sergy Haut, France; email: <email xlink:href="dfedson@wanadoo.fr">dfedson@wanadoo.fr</email></corresp></author-notes><pub-date pub-type="ppub"><month>3</month><year>2009</year></pub-date><volume>15</volume><issue>3</issue><fpage>365</fpage><lpage>371</lpage><abstract abstract-type="toc"><p>One-sentence summary for table of contents: These countries should consider using inexpensive generic agents to confront the next pandemic.</p></abstract><abstract><p>Developing countries face unique difficulties preparing for an influenza pandemic. Our current top-down approach will not provide these countries with adequate supplies of vaccines and antiviral agents. Consequently, they will have to use a bottom-up approach based on inexpensive generic agents that either modify the host response to influenza virus or act as antiviral agents. Several of these agents have shown promise, and many are currently produced in developing countries. Investigators must primarily identify agents for managing infection in populations and not simply seek explanations for how they work. They must determine in which countries these agents are produced and define patterns of distribution and costs. Because prepandemic research cannot establish whether these agents will be effective in a pandemic, randomized controlled trials must begin immediately after a new pandemic virus has emerged. Without this research, industrialized and developing countries could face an unprecedented health crisis.</p></abstract><kwd-group kwd-group-type="author" xml:lang="EN"><title>Keywords: </title><kwd>Pandemic</kwd><kwd>influenza</kwd><kwd>developing countries</kwd><kwd>H5N1</kwd><kwd>generic agents</kwd><kwd>statins</kwd><kwd>PPAR agonists</kwd><kwd>World Health Organization</kwd><kwd>perspective</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Fedson, David S" sort="Fedson, David S" uniqKey="Fedson D" first="David S." last="Fedson">David S. Fedson</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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