Avian Influenza Virus (H5N1): a Threat to Human Health
Identifieur interne : 000217 ( Ncbi/Merge ); précédent : 000216; suivant : 000218Avian Influenza Virus (H5N1): a Threat to Human Health
Auteurs : J. S. Malik Peiris ; Menno D. De Jong ; Yi GuanSource :
- Clinical Microbiology Reviews [ 0893-8512 ] ; 2007.
Abstract
Pandemic influenza virus has its origins in avian influenza viruses. The highly pathogenic avian influenza virus subtype H5N1 is already panzootic in poultry, with attendant economic consequences. It continues to cross species barriers to infect humans and other mammals, often with fatal outcomes. Therefore, H5N1 virus has rightly received attention as a potential pandemic threat. However, it is noted that the pandemics of 1957 and 1968 did not arise from highly pathogenic influenza viruses, and the next pandemic may well arise from a low-pathogenicity virus. The rationale for particular concern about an H5N1 pandemic is not its inevitability but its potential severity. An H5N1 pandemic is an event of low probability but one of high human health impact and poses a predicament for public health. Here, we review the ecology and evolution of highly pathogenic avian influenza H5N1 viruses, assess the pandemic risk, and address aspects of human H5N1 disease in relation to its epidemiology, clinical presentation, pathogenesis, diagnosis, and management.
Url:
DOI: 10.1128/CMR.00037-06
PubMed: 17428885
PubMed Central: 1865597
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Microbiol Rev</journal-id><journal-id journal-id-type="publisher-id">cmr</journal-id><journal-title>Clinical Microbiology Reviews</journal-title><issn pub-type="ppub">0893-8512</issn><issn pub-type="epub">1098-6618</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17428885</article-id><article-id pub-id-type="pmc">1865597</article-id><article-id pub-id-type="publisher-id">0037-06</article-id><article-id pub-id-type="doi">10.1128/CMR.00037-06</article-id><article-categories><subj-group subj-group-type="heading"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Avian Influenza Virus (H5N1): a Threat to Human Health</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Peiris</surname><given-names>J. S. Malik</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>de Jong</surname><given-names>Menno D.</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Guan</surname><given-names>Yi</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1">Department of Microbiology, University Pathology Building, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, SAR, People's Republic of China,<label>1</label> Hong Kong University—Pasteur Research Centre, Sassoon Rd., Pokfulam, Hong Kong, SAR, People's Republic of China,<label>2</label> Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam<label>3</label></aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address: Department of Microbiology, University Pathology Building, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, SAR, People's Republic of China. Phone: (852) 2855-4888. Fax: (852) 2855-1241. E-mail: <email>malik@hkucc.hku.hk</email></p></fn></author-notes><pub-date pub-type="ppub"><month>4</month><year>2007</year></pub-date><volume>20</volume><issue>2</issue><fpage>243</fpage><lpage>267</lpage><copyright-statement>Copyright © 2007, American Society for Microbiology</copyright-statement><copyright-year>2007</copyright-year><self-uri xlink:title="pdf" xlink:href="zcm00207000243.pdf"></self-uri><abstract><p>Pandemic influenza virus has its origins in avian influenza viruses. The highly pathogenic avian influenza virus subtype H5N1 is already panzootic in poultry, with attendant economic consequences. It continues to cross species barriers to infect humans and other mammals, often with fatal outcomes. Therefore, H5N1 virus has rightly received attention as a potential pandemic threat. However, it is noted that the pandemics of 1957 and 1968 did not arise from highly pathogenic influenza viruses, and the next pandemic may well arise from a low-pathogenicity virus. The rationale for particular concern about an H5N1 pandemic is not its inevitability but its potential severity. An H5N1 pandemic is an event of low probability but one of high human health impact and poses a predicament for public health. Here, we review the ecology and evolution of highly pathogenic avian influenza H5N1 viruses, assess the pandemic risk, and address aspects of human H5N1 disease in relation to its epidemiology, clinical presentation, pathogenesis, diagnosis, and management.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="De Jong, Menno D" sort="De Jong, Menno D" uniqKey="De Jong M" first="Menno D." last="De Jong">Menno D. De Jong</name><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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