[Sensitivity of various influenza virus strains to arbidol. Influence of arbidol combination with different antiviral drugs on reproduction of influenza virus A].
Identifieur interne : 000137 ( Ncbi/Merge ); précédent : 000136; suivant : 000138[Sensitivity of various influenza virus strains to arbidol. Influence of arbidol combination with different antiviral drugs on reproduction of influenza virus A].
Auteurs : I A Leneva ; I T Fediakina ; T A Gus'Kova ; R G GlushkovSource :
- Terapevticheskii arkhiv [ 0040-3660 ] ; 2005.
Descripteurs français
- KwdFr :
- Amantadine (pharmacologie), Amantadine (usage thérapeutique), Animaux, Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Association de médicaments, Chiens, Embryon de mammifère, Grippe humaine (traitement médicamenteux), Indoles (pharmacologie), Indoles (usage thérapeutique), Ribavirine (pharmacologie), Ribavirine (usage thérapeutique), Réplication virale (), Tests de sensibilité microbienne, Virus de la grippe A (), Virus influenza B ().
- MESH :
- pharmacologie : Amantadine, Antiviraux, Indoles, Ribavirine.
- traitement médicamenteux : Grippe humaine.
- usage thérapeutique : Amantadine, Antiviraux, Indoles, Ribavirine.
- Animaux, Association de médicaments, Chiens, Embryon de mammifère, Réplication virale, Tests de sensibilité microbienne, Virus de la grippe A, Virus influenza B.
English descriptors
- KwdEn :
- Amantadine (pharmacology), Amantadine (therapeutic use), Animals, Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Dogs, Drug Therapy, Combination, Embryo, Mammalian, Indoles (pharmacology), Indoles (therapeutic use), Influenza A virus (drug effects), Influenza B virus (drug effects), Influenza, Human (drug therapy), Microbial Sensitivity Tests, Ribavirin (pharmacology), Ribavirin (therapeutic use), Virus Replication (drug effects).
- MESH :
- chemical , pharmacology : Amantadine, Antiviral Agents, Indoles, Ribavirin.
- chemical , therapeutic use : Amantadine, Antiviral Agents, Indoles, Ribavirin.
- drug effects : Influenza A virus, Influenza B virus, Virus Replication.
- drug therapy : Influenza, Human.
- Animals, Dogs, Drug Therapy, Combination, Embryo, Mammalian, Microbial Sensitivity Tests.
Abstract
To study antiviral activity of arbidol in relation to various antigenic subtypes of influenza virus isolated from humans; efficacy of arbidol action in combination with adamantanic antiviral drugs, ribavirin and ribamidil on reproduction of influenza virus A (IVA) in cell culture.
PubMed: 16206613
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pubmed:16206613Le document en format XML
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Influence of arbidol combination with different antiviral drugs on reproduction of influenza virus A].</title><author><name sortKey="Leneva, I A" sort="Leneva, I A" uniqKey="Leneva I" first="I A" last="Leneva">I A Leneva</name></author><author><name sortKey="Fediakina, I T" sort="Fediakina, I T" uniqKey="Fediakina I" first="I T" last="Fediakina">I T Fediakina</name></author><author><name sortKey="Gus Kova, T A" sort="Gus Kova, T A" uniqKey="Gus Kova T" first="T A" last="Gus'Kova">T A Gus'Kova</name></author><author><name sortKey="Glushkov, R G" sort="Glushkov, R G" uniqKey="Glushkov R" first="R G" last="Glushkov">R G Glushkov</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16206613</idno><idno type="pmid">16206613</idno><idno type="wicri:Area/PubMed/Corpus">000316</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000316</idno><idno type="wicri:Area/PubMed/Curation">000316</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000316</idno><idno type="wicri:Area/PubMed/Checkpoint">000286</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000286</idno><idno type="wicri:Area/Ncbi/Merge">000137</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Sensitivity of various influenza virus strains to arbidol. Influence of arbidol combination with different antiviral drugs on reproduction of influenza virus A].</title><author><name sortKey="Leneva, I A" sort="Leneva, I A" uniqKey="Leneva I" first="I A" last="Leneva">I A Leneva</name></author><author><name sortKey="Fediakina, I T" sort="Fediakina, I T" uniqKey="Fediakina I" first="I T" last="Fediakina">I T Fediakina</name></author><author><name sortKey="Gus Kova, T A" sort="Gus Kova, T A" uniqKey="Gus Kova T" first="T A" last="Gus'Kova">T A Gus'Kova</name></author><author><name sortKey="Glushkov, R G" sort="Glushkov, R G" uniqKey="Glushkov R" first="R G" last="Glushkov">R G Glushkov</name></author></analytic><series><title level="j">Terapevticheskii arkhiv</title><idno type="ISSN">0040-3660</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amantadine (pharmacology)</term><term>Amantadine (therapeutic use)</term><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Dogs</term><term>Drug Therapy, Combination</term><term>Embryo, Mammalian</term><term>Indoles (pharmacology)</term><term>Indoles (therapeutic use)</term><term>Influenza A virus (drug effects)</term><term>Influenza B virus (drug effects)</term><term>Influenza, Human (drug therapy)</term><term>Microbial Sensitivity Tests</term><term>Ribavirin (pharmacology)</term><term>Ribavirin (therapeutic use)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amantadine (pharmacologie)</term><term>Amantadine (usage thérapeutique)</term><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Association de médicaments</term><term>Chiens</term><term>Embryon de mammifère</term><term>Grippe humaine (traitement médicamenteux)</term><term>Indoles (pharmacologie)</term><term>Indoles (usage thérapeutique)</term><term>Ribavirine (pharmacologie)</term><term>Ribavirine (usage thérapeutique)</term><term>Réplication virale ()</term><term>Tests de sensibilité microbienne</term><term>Virus de la grippe A ()</term><term>Virus influenza B ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Amantadine</term><term>Antiviral Agents</term><term>Indoles</term><term>Ribavirin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Amantadine</term><term>Antiviral Agents</term><term>Indoles</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Influenza A virus</term><term>Influenza B virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Amantadine</term><term>Antiviraux</term><term>Indoles</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Amantadine</term><term>Antiviraux</term><term>Indoles</term><term>Ribavirine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dogs</term><term>Drug Therapy, Combination</term><term>Embryo, Mammalian</term><term>Microbial Sensitivity Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Association de médicaments</term><term>Chiens</term><term>Embryon de mammifère</term><term>Réplication virale</term><term>Tests de sensibilité microbienne</term><term>Virus de la grippe A</term><term>Virus influenza B</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To study antiviral activity of arbidol in relation to various antigenic subtypes of influenza virus isolated from humans; efficacy of arbidol action in combination with adamantanic antiviral drugs, ribavirin and ribamidil on reproduction of influenza virus A (IVA) in cell culture.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16206613</PMID><DateCompleted><Year>2005</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0040-3660</ISSN><JournalIssue CitedMedium="Print"><Volume>77</Volume><Issue>8</Issue><PubDate><Year>2005</Year></PubDate></JournalIssue><Title>Terapevticheskii arkhiv</Title><ISOAbbreviation>Ter. Arkh.</ISOAbbreviation></Journal><ArticleTitle>[Sensitivity of various influenza virus strains to arbidol. Influence of arbidol combination with different antiviral drugs on reproduction of influenza virus A].</ArticleTitle><Pagination><MedlinePgn>84-8</MedlinePgn></Pagination><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">To study antiviral activity of arbidol in relation to various antigenic subtypes of influenza virus isolated from humans; efficacy of arbidol action in combination with adamantanic antiviral drugs, ribavirin and ribamidil on reproduction of influenza virus A (IVA) in cell culture.</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">The activity of the drugs against viral reproduction was assessed by inhibition of viral antigens expression detected in virus-infected cells using enzyme immunoassay (EIA).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Arbidol is not inferior to adamantanic drugs, neuraminidase inhibitors, ribavirin and ribamidil by its inhibiting activity in relation to influenza viruses A and B. Arbidol inhibits reproduction of human IVA antigenic strains H1N1, H2N2, H3N2 and remantadin-sensitive and remantadin-resistant strains of influenza virus. Arbidol inhibits reproduction of pathogenic for humans strains of avian influenza virus H5N1 and H9N2, strains H6N1 and H9N2 having internal genes common with H5N1 and H9N2. The inhibiting activity of arbidolin on cell culture viral reproduction enhanced if arbidol was used in combination with amantadine, remantadin, ribavirin and ribamidil.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Arbidol has a wide spectrum antiviral activity and inhibits reproduction of various antigenic subtypes and remantadin-resistent human IVA, avian viruses H5N1 and H9N2, influenza viruses B and C.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Leneva</LastName><ForeName>I A</ForeName><Initials>IA</Initials></Author><Author ValidYN="Y"><LastName>Fediakina</LastName><ForeName>I T</ForeName><Initials>IT</Initials></Author><Author ValidYN="Y"><LastName>Gus'kova</LastName><ForeName>T A</ForeName><Initials>TA</Initials></Author><Author ValidYN="Y"><LastName>Glushkov</LastName><ForeName>R G</ForeName><Initials>RG</Initials></Author></AuthorList><Language>rus</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Russia (Federation)</Country><MedlineTA>Ter Arkh</MedlineTA><NlmUniqueID>2984818R</NlmUniqueID><ISSNLinking>0040-3660</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007211">Indoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>49717AWG6K</RegistryNumber><NameOfSubstance UI="D012254">Ribavirin</NameOfSubstance></Chemical><Chemical><RegistryNumber>93M09WW4RU</RegistryNumber><NameOfSubstance UI="C086979">arbidol</NameOfSubstance></Chemical><Chemical><RegistryNumber>BF4C9Z1J53</RegistryNumber><NameOfSubstance 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Mammalian</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007211" MajorTopicYN="N">Indoles</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009981" MajorTopicYN="N">Influenza B virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012254" MajorTopicYN="N">Ribavirin</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>10</Month><Day>7</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>12</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>10</Month><Day>7</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16206613</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Fediakina, I T" sort="Fediakina, I T" uniqKey="Fediakina I" first="I T" last="Fediakina">I T Fediakina</name><name sortKey="Glushkov, R G" sort="Glushkov, R G" uniqKey="Glushkov R" first="R G" last="Glushkov">R G Glushkov</name><name sortKey="Gus Kova, T A" sort="Gus Kova, T A" uniqKey="Gus Kova T" first="T A" last="Gus'Kova">T A Gus'Kova</name><name sortKey="Leneva, I A" sort="Leneva, I A" uniqKey="Leneva I" first="I A" last="Leneva">I A Leneva</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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