Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice.
Identifieur interne : 001356 ( Ncbi/Curation ); précédent : 001355; suivant : 001357Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice.
Auteurs : K. Sato [Japon] ; M. Suga ; T. Akaike ; S. Fujii ; H. Muranaka ; T. Doi ; H. Maeda ; M. AndoSource :
- American journal of respiratory and critical care medicine [ 1073-449X ] ; 1998.
Descripteurs français
- KwdFr :
- Animaux, Anti-inflammatoires (administration et posologie), Anti-inflammatoires (usage thérapeutique), Antibactériens (administration et posologie), Antibactériens (usage thérapeutique), Cause de décès, Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (enzymologie), Infections à Orthomyxoviridae (traitement médicamenteux), Injections péritoneales, Interféron gamma (), Interféron gamma (biosynthèse), Lignées consanguines de souris, Liquide de lavage bronchoalvéolaire (cytologie), Lymphocytes (), Lymphocytes (anatomopathologie), Macrophages (), Macrophages (anatomopathologie), Monocytes (), Monocytes (anatomopathologie), Monoxyde d'azote (biosynthèse), Monoxyde d'azote (effets indésirables), Mâle, Nitrates (sang), Nitric oxide synthase (), Nitrites (sang), Pneumopathie virale (anatomopathologie), Pneumopathie virale (enzymologie), Pneumopathie virale (traitement médicamenteux), Poids du corps, Poumon (), Poumon (anatomopathologie), Poumon (enzymologie), Poumon (virologie), Radicaux libres (effets indésirables), Relation dose-effet des médicaments, Souris, Superoxydes (effets indésirables), Taux de survie, Virus de la grippe A (), Érythromycine (administration et posologie), Érythromycine (usage thérapeutique).
- MESH :
- administration et posologie : Anti-inflammatoires, Antibactériens, Érythromycine.
- anatomopathologie : Infections à Orthomyxoviridae, Lymphocytes, Macrophages, Monocytes, Pneumopathie virale, Poumon.
- biosynthèse : Interféron gamma, Monoxyde d'azote.
- cytologie : Liquide de lavage bronchoalvéolaire.
- effets indésirables : Monoxyde d'azote, Radicaux libres, Superoxydes.
- enzymologie : Infections à Orthomyxoviridae, Pneumopathie virale, Poumon.
- sang : Nitrates, Nitrites.
- traitement médicamenteux : Infections à Orthomyxoviridae, Pneumopathie virale.
- usage thérapeutique : Anti-inflammatoires, Antibactériens, Érythromycine.
- virologie : Poumon.
- Animaux, Cause de décès, Injections péritoneales, Interféron gamma, Lignées consanguines de souris, Lymphocytes, Macrophages, Monocytes, Mâle, Nitric oxide synthase, Poids du corps, Poumon, Relation dose-effet des médicaments, Souris, Taux de survie, Virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Anti-Bacterial Agents (administration & dosage), Anti-Bacterial Agents (therapeutic use), Anti-Inflammatory Agents (administration & dosage), Anti-Inflammatory Agents (therapeutic use), Body Weight, Bronchoalveolar Lavage Fluid (cytology), Cause of Death, Dose-Response Relationship, Drug, Erythromycin (administration & dosage), Erythromycin (therapeutic use), Free Radicals (adverse effects), Influenza A virus (drug effects), Injections, Intraperitoneal, Interferon-gamma (biosynthesis), Interferon-gamma (drug effects), Lung (drug effects), Lung (enzymology), Lung (pathology), Lung (virology), Lymphocytes (drug effects), Lymphocytes (pathology), Macrophages (drug effects), Macrophages (pathology), Male, Mice, Mice, Inbred Strains, Monocytes (drug effects), Monocytes (pathology), Nitrates (blood), Nitric Oxide (adverse effects), Nitric Oxide (biosynthesis), Nitric Oxide Synthase (drug effects), Nitrites (blood), Orthomyxoviridae Infections (drug therapy), Orthomyxoviridae Infections (enzymology), Orthomyxoviridae Infections (pathology), Pneumonia, Viral (drug therapy), Pneumonia, Viral (enzymology), Pneumonia, Viral (pathology), Superoxides (adverse effects), Survival Rate.
- MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Anti-Inflammatory Agents, Erythromycin.
- chemical , adverse effects : Free Radicals, Nitric Oxide, Superoxides.
- chemical , biosynthesis : Interferon-gamma, Nitric Oxide.
- chemical , blood : Nitrates, Nitrites.
- chemical , drug effects : Interferon-gamma, Nitric Oxide Synthase.
- chemical , therapeutic use : Anti-Bacterial Agents, Anti-Inflammatory Agents, Erythromycin.
- cytology : Bronchoalveolar Lavage Fluid.
- drug effects : Influenza A virus, Lung, Lymphocytes, Macrophages, Monocytes.
- drug therapy : Orthomyxoviridae Infections, Pneumonia, Viral.
- enzymology : Lung, Orthomyxoviridae Infections, Pneumonia, Viral.
- pathology : Lung, Lymphocytes, Macrophages, Monocytes, Orthomyxoviridae Infections, Pneumonia, Viral.
- virology : Lung.
- Animals, Body Weight, Cause of Death, Dose-Response Relationship, Drug, Injections, Intraperitoneal, Male, Mice, Mice, Inbred Strains, Survival Rate.
Abstract
Erythromycin (EM) is an antibiotic with potent antiinflammatory effects that is used for treating chronic lower respiratory tract infections. It has been shown that free radicals, such as the superoxide anion and nitric oxide (NO), are pathogenic molecules in viral disease. Much attention has been given to a critical role of NO in the pathologic events of various inflammatory diseases. In the present study, we evaluated the effects of EM on influenza-virus-induced pneumonia in mice infected with a lethal dose of influenza virus A/Kumamoto/Y5/67 (H2N2). The administration of EM at a dose of 3.3 mg/kg/d (intraperitoneally, from Days 1 to 6 after infection), significantly improved the survival rate of mice infected with influenza virus, and the survival rate of the virus-infected mice at Day 20 after infection increased in a dose-dependent fashion with EM administered to the animals, from 14% among controls to 42% among animals given EM at 1.0 mg/kg/d and 57% among those given EM at 3.3 mg/kg/d. The induction of interferon-gamma (IFN-gamma) in the mouse lung was inhibited by EM treatment on Day 6 after infection. Simultaneously, the number of inflammatory cells recovered in lung lavage fluid 6 d after virus infection was significantly reduced by the treatment with EM. The EM treatment resulted in a dose-dependent decrease in the level of nitrite/nitrate (metabolites of NO) in the serum and the NO synthase (NOS)-inducting potential in the lungs of the virus-infected mice. These results indicate that EM may have substantial therapeutic value for various acute inflammatory disorders such as influenza-virus-induced pneumonia, by inhibiting inflammatory-cell responses and suppressing NO overproduction in the lung.
DOI: 10.1164/ajrccm.157.3.9703098
PubMed: 9517602
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice.</title><author><name sortKey="Sato, K" sort="Sato, K" uniqKey="Sato K" first="K" last="Sato">K. Sato</name><affiliation wicri:level="1"><nlm:affiliation>First Department of Internal Medicine, Kumamoto University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>First Department of Internal Medicine, Kumamoto University School of Medicine</wicri:regionArea><wicri:noRegion>Kumamoto University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Suga, M" sort="Suga, M" uniqKey="Suga M" first="M" last="Suga">M. Suga</name></author><author><name sortKey="Akaike, T" sort="Akaike, T" uniqKey="Akaike T" first="T" last="Akaike">T. Akaike</name></author><author><name sortKey="Fujii, S" sort="Fujii, S" uniqKey="Fujii S" first="S" last="Fujii">S. Fujii</name></author><author><name sortKey="Muranaka, H" sort="Muranaka, H" uniqKey="Muranaka H" first="H" last="Muranaka">H. Muranaka</name></author><author><name sortKey="Doi, T" sort="Doi, T" uniqKey="Doi T" first="T" last="Doi">T. Doi</name></author><author><name sortKey="Maeda, H" sort="Maeda, H" uniqKey="Maeda H" first="H" last="Maeda">H. Maeda</name></author><author><name sortKey="Ando, M" sort="Ando, M" uniqKey="Ando M" first="M" last="Ando">M. Ando</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9517602</idno><idno type="pmid">9517602</idno><idno type="doi">10.1164/ajrccm.157.3.9703098</idno><idno type="wicri:Area/PubMed/Corpus">000386</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000386</idno><idno type="wicri:Area/PubMed/Curation">000386</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000386</idno><idno type="wicri:Area/PubMed/Checkpoint">000345</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000345</idno><idno type="wicri:Area/Ncbi/Merge">001356</idno><idno type="wicri:Area/Ncbi/Curation">001356</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Therapeutic effect of erythromycin on influenza virus-induced lung injury in mice.</title><author><name sortKey="Sato, K" sort="Sato, K" uniqKey="Sato K" first="K" last="Sato">K. Sato</name><affiliation wicri:level="1"><nlm:affiliation>First Department of Internal Medicine, Kumamoto University School of Medicine, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>First Department of Internal Medicine, Kumamoto University School of Medicine</wicri:regionArea><wicri:noRegion>Kumamoto University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Suga, M" sort="Suga, M" uniqKey="Suga M" first="M" last="Suga">M. Suga</name></author><author><name sortKey="Akaike, T" sort="Akaike, T" uniqKey="Akaike T" first="T" last="Akaike">T. Akaike</name></author><author><name sortKey="Fujii, S" sort="Fujii, S" uniqKey="Fujii S" first="S" last="Fujii">S. Fujii</name></author><author><name sortKey="Muranaka, H" sort="Muranaka, H" uniqKey="Muranaka H" first="H" last="Muranaka">H. Muranaka</name></author><author><name sortKey="Doi, T" sort="Doi, T" uniqKey="Doi T" first="T" last="Doi">T. 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(biosynthesis)</term><term>Interferon-gamma (drug effects)</term><term>Lung (drug effects)</term><term>Lung (enzymology)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Lymphocytes (drug effects)</term><term>Lymphocytes (pathology)</term><term>Macrophages (drug effects)</term><term>Macrophages (pathology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Monocytes (drug effects)</term><term>Monocytes (pathology)</term><term>Nitrates (blood)</term><term>Nitric Oxide (adverse effects)</term><term>Nitric Oxide (biosynthesis)</term><term>Nitric Oxide Synthase (drug effects)</term><term>Nitrites (blood)</term><term>Orthomyxoviridae Infections (drug therapy)</term><term>Orthomyxoviridae Infections (enzymology)</term><term>Orthomyxoviridae Infections (pathology)</term><term>Pneumonia, Viral (drug therapy)</term><term>Pneumonia, Viral (enzymology)</term><term>Pneumonia, Viral (pathology)</term><term>Superoxides (adverse 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Orthomyxoviridae</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anti-inflammatoires</term><term>Antibactériens</term><term>Érythromycine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Body Weight</term><term>Cause of Death</term><term>Dose-Response Relationship, Drug</term><term>Injections, Intraperitoneal</term><term>Male</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cause de décès</term><term>Injections péritoneales</term><term>Interféron gamma</term><term>Lignées consanguines de souris</term><term>Lymphocytes</term><term>Macrophages</term><term>Monocytes</term><term>Mâle</term><term>Nitric oxide synthase</term><term>Poids du corps</term><term>Poumon</term><term>Relation dose-effet des médicaments</term><term>Souris</term><term>Taux de survie</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Erythromycin (EM) is an antibiotic with potent antiinflammatory effects that is used for treating chronic lower respiratory tract infections. It has been shown that free radicals, such as the superoxide anion and nitric oxide (NO), are pathogenic molecules in viral disease. Much attention has been given to a critical role of NO in the pathologic events of various inflammatory diseases. In the present study, we evaluated the effects of EM on influenza-virus-induced pneumonia in mice infected with a lethal dose of influenza virus A/Kumamoto/Y5/67 (H2N2). The administration of EM at a dose of 3.3 mg/kg/d (intraperitoneally, from Days 1 to 6 after infection), significantly improved the survival rate of mice infected with influenza virus, and the survival rate of the virus-infected mice at Day 20 after infection increased in a dose-dependent fashion with EM administered to the animals, from 14% among controls to 42% among animals given EM at 1.0 mg/kg/d and 57% among those given EM at 3.3 mg/kg/d. The induction of interferon-gamma (IFN-gamma) in the mouse lung was inhibited by EM treatment on Day 6 after infection. Simultaneously, the number of inflammatory cells recovered in lung lavage fluid 6 d after virus infection was significantly reduced by the treatment with EM. The EM treatment resulted in a dose-dependent decrease in the level of nitrite/nitrate (metabolites of NO) in the serum and the NO synthase (NOS)-inducting potential in the lungs of the virus-infected mice. These results indicate that EM may have substantial therapeutic value for various acute inflammatory disorders such as influenza-virus-induced pneumonia, by inhibiting inflammatory-cell responses and suppressing NO overproduction in the lung.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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