The use of live attenuated influenza vaccine ts-1(E) in man.
Identifieur interne : 001297 ( Ncbi/Curation ); précédent : 001296; suivant : 001298The use of live attenuated influenza vaccine ts-1(E) in man.
Auteurs : J M GwaltneySource :
- Developments in biological standardization [ 0301-5149 ] ; 1976.
Descripteurs français
- KwdFr :
- Administration par voie nasale, Adulte, Anticorps antiviraux (analyse), Enfant, Essais cliniques comme sujet, Femelle, Grippe humaine (), Humains, Mâle, Sialidase (immunologie), Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (effets indésirables), Vaccins antigrippaux (usage thérapeutique), Vaccins atténués (administration et posologie), Vaccins atténués (effets indésirables), Virus de la grippe A (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués.
- analyse : Anticorps antiviraux.
- effets indésirables : Vaccins antigrippaux, Vaccins atténués.
- immunologie : Sialidase, Virus de la grippe A.
- usage thérapeutique : Vaccins antigrippaux.
- Administration par voie nasale, Adulte, Enfant, Essais cliniques comme sujet, Femelle, Grippe humaine, Humains, Mâle, Tests d'inhibition de l'hémagglutination.
English descriptors
- KwdEn :
- Administration, Intranasal, Adult, Antibodies, Viral (analysis), Child, Clinical Trials as Topic, Female, Hemagglutination Inhibition Tests, Humans, Influenza A virus (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (adverse effects), Influenza Vaccines (therapeutic use), Influenza, Human (prevention & control), Male, Neuraminidase (immunology), Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (adverse effects).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated.
- chemical , adverse effects : Influenza Vaccines, Vaccines, Attenuated.
- chemical , analysis : Antibodies, Viral.
- immunology : Influenza A virus, Neuraminidase.
- prevention & control : Influenza, Human.
- chemical , therapeutic use : Influenza Vaccines.
- Administration, Intranasal, Adult, Child, Clinical Trials as Topic, Female, Hemagglutination Inhibition Tests, Humans, Male.
Abstract
Live temperature-sensitive influenza virus vaccines were tested in two volunteer experiments. The vaccine virus was originally derived from a temperature-sensitive mutant of influenza A/Great Lakes/1965 (H2N2) produced by chemical mutagenesis with 5-fluorouracil. The ts lesions of this strain were subsequently transferred (HI) antibody. Only 9 men (13%) were infected, presumably as a result of over-attenuation of the virus and/or insufficient titer of the inoculum. In the second experiment (1974), 20 young adults were given 0.5 ml per nostril of vaccine containing a recombinant of influenza A/Udorn/307/72 clone 24 (10(5.5) TCID50/ml) with an in vitro shutoff temperature of 38 degree C. Virus was shed by seven volunteers (maximum titer, 10(2.5)TCID50/ml). None of 21 isolates contained revertant wild type virus. Serum HI and antieuraminidase (NI) and nasal wash neutralizing antibody responses occurred in 11 (55%), 7 (35%), and 8 (40%) volunteers, respectively. Post-vaccination serum HI and NI and nasal neutralizing antibody geometric mean titers were 3.0, 9.4, and 1.7 lob2, respectively. Seven volunteers judged they had colds (symptom scores 4-32). Rhinitis and mild pharyngeal discomfort were the only consistent complaints and fever was absent. The findings in the latter trial will be compared with results of volunteer experiments with Udorn/72 ts-1-(E) in other laboratories and to studies with standard inactivated influenza vaccines given parenterally.
PubMed: 782966
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pubmed:782966Le document en format XML
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<term>Clinical Trials as Topic</term>
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<term>Adulte</term>
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<term>Essais cliniques comme sujet</term>
<term>Femelle</term>
<term>Grippe humaine ()</term>
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<term>Virus de la grippe A (immunologie)</term>
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<term>Vaccines, Attenuated</term>
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<term>Vaccins atténués</term>
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<term>Virus de la grippe A</term>
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<term>Adult</term>
<term>Child</term>
<term>Clinical Trials as Topic</term>
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<term>Hemagglutination Inhibition Tests</term>
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<term>Adulte</term>
<term>Enfant</term>
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<term>Femelle</term>
<term>Grippe humaine</term>
<term>Humains</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en">Live temperature-sensitive influenza virus vaccines were tested in two volunteer experiments. The vaccine virus was originally derived from a temperature-sensitive mutant of influenza A/Great Lakes/1965 (H2N2) produced by chemical mutagenesis with 5-fluorouracil. The ts lesions of this strain were subsequently transferred (HI) antibody. Only 9 men (13%) were infected, presumably as a result of over-attenuation of the virus and/or insufficient titer of the inoculum. In the second experiment (1974), 20 young adults were given 0.5 ml per nostril of vaccine containing a recombinant of influenza A/Udorn/307/72 clone 24 (10(5.5) TCID50/ml) with an in vitro shutoff temperature of 38 degree C. Virus was shed by seven volunteers (maximum titer, 10(2.5)TCID50/ml). None of 21 isolates contained revertant wild type virus. Serum HI and antieuraminidase (NI) and nasal wash neutralizing antibody responses occurred in 11 (55%), 7 (35%), and 8 (40%) volunteers, respectively. Post-vaccination serum HI and NI and nasal neutralizing antibody geometric mean titers were 3.0, 9.4, and 1.7 lob2, respectively. Seven volunteers judged they had colds (symptom scores 4-32). Rhinitis and mild pharyngeal discomfort were the only consistent complaints and fever was absent. The findings in the latter trial will be compared with results of volunteer experiments with Udorn/72 ts-1-(E) in other laboratories and to studies with standard inactivated influenza vaccines given parenterally.</div>
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