OVX836 a recombinant nucleoprotein vaccine inducing cellular responses and protective efficacy against multiple influenza A subtypes
Identifieur interne : 000F61 ( Ncbi/Curation ); précédent : 000F60; suivant : 000F62OVX836 a recombinant nucleoprotein vaccine inducing cellular responses and protective efficacy against multiple influenza A subtypes
Auteurs : Judith Del Campo [France] ; Andres Pizzorno ; Sophia Djebali [France] ; Julien Bouley [France] ; Marjorie Haller [France] ; Jimena Pérez-Vargas [France] ; Bruno Lina [France] ; Guy Boivin [Canada] ; Marie-Eve Hamelin [Canada] ; Florence Nicolas [France] ; Alexandre Le Vert [France] ; Yann Leverrier [France] ; Manuel Rosa-Calatrava ; Jacqueline Marvel [France] ; Fergal Hill [France]Source :
- NPJ Vaccines [ 2059-0105 ] ; 2019.
Abstract
Inactivated influenza vaccines (IIVs) lack broad efficacy. Cellular immunity to a conserved internal antigen, the nucleoprotein (NP), has been correlated to protection against pandemic and seasonal influenza and thus could have the potential to broaden vaccine efficacy. We developed OVX836, a recombinant protein vaccine based on an oligomerized NP, which shows increased uptake by dendritic cells and immunogenicity compared with NP. Intramuscular immunization in mice with OVX836 induced strong NP-specific CD4+ and CD8+ T-cell systemic responses and established CD8+ tissue memory T cells in the lung parenchyma. Strikingly, OVX836 protected mice against viral challenge with three different influenza A subtypes, isolated several decades apart and induced a reduction in viral load. When co-administered with IIV, OVX836 was even more effective in reducing lung viral load.
Url:
DOI: 10.1038/s41541-019-0098-4
PubMed: 30701093
PubMed Central: 6344521
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<institution>Centre International de Recherche en Infectiologie, INSERM U1111, CNRS UMR5308, École Normale Supérieure de Lyon, Université Claude Bernard Lyon 1. Université de Lyon,</institution>
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Lyon, F- 69008 France</nlm:aff>
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Québec, Canada</nlm:aff>
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F-69007 Lyon, France</nlm:aff>
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<author><name sortKey="Rosa Calatrava, Manuel" sort="Rosa Calatrava, Manuel" uniqKey="Rosa Calatrava M" first="Manuel" last="Rosa-Calatrava">Manuel Rosa-Calatrava</name>
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<author><name sortKey="Marvel, Jacqueline" sort="Marvel, Jacqueline" uniqKey="Marvel J" first="Jacqueline" last="Marvel">Jacqueline Marvel</name>
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F-69007 Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
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</author>
<author><name sortKey="Hill, Fergal" sort="Hill, Fergal" uniqKey="Hill F" first="Fergal" last="Hill">Fergal Hill</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">Osivax, 99, rue de Gerland, 69007 Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Osivax, 99, rue de Gerland, 69007 Lyon</wicri:regionArea>
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</analytic>
<series><title level="j">NPJ Vaccines</title>
<idno type="eISSN">2059-0105</idno>
<imprint><date when="2019">2019</date>
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<front><div type="abstract" xml:lang="en"><p id="Par1">Inactivated influenza vaccines (IIVs) lack broad efficacy. Cellular immunity to a conserved internal antigen, the nucleoprotein (NP), has been correlated to protection against pandemic and seasonal influenza and thus could have the potential to broaden vaccine efficacy. We developed OVX836, a recombinant protein vaccine based on an oligomerized NP, which shows increased uptake by dendritic cells and immunogenicity compared with NP. Intramuscular immunization in mice with OVX836 induced strong NP-specific CD4+ and CD8+ T-cell systemic responses and established CD8+ tissue memory T cells in the lung parenchyma. Strikingly, OVX836 protected mice against viral challenge with three different influenza A subtypes, isolated several decades apart and induced a reduction in viral load. When co-administered with IIV, OVX836 was even more effective in reducing lung viral load.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Belongia, Ea" uniqKey="Belongia E">EA Belongia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xie, H" uniqKey="Xie H">H Xie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Flannery, B" uniqKey="Flannery B">B Flannery</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chambers, Bs" uniqKey="Chambers B">BS Chambers</name>
</author>
<author><name sortKey="Parkhouse, K" uniqKey="Parkhouse K">K Parkhouse</name>
</author>
<author><name sortKey="Ross, Tm" uniqKey="Ross T">TM Ross</name>
</author>
<author><name sortKey="Alby, K" uniqKey="Alby K">K Alby</name>
</author>
<author><name sortKey="Hensley, Se" uniqKey="Hensley S">SE Hensley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tricco, Ac" uniqKey="Tricco A">AC Tricco</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sridhar, S" uniqKey="Sridhar S">S Sridhar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilkinson, Tm" uniqKey="Wilkinson T">TM Wilkinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hayward, Ac" uniqKey="Hayward A">AC Hayward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gorman, Ot" uniqKey="Gorman O">OT Gorman</name>
</author>
<author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name>
</author>
<author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Machkovech, Hm" uniqKey="Machkovech H">HM Machkovech</name>
</author>
<author><name sortKey="Bedford, T" uniqKey="Bedford T">T Bedford</name>
</author>
<author><name sortKey="Suchard, Ma" uniqKey="Suchard M">MA Suchard</name>
</author>
<author><name sortKey="Bloom, Jd" uniqKey="Bloom J">JD Bloom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hessel, A" uniqKey="Hessel A">A Hessel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, C" uniqKey="Wu C">C Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grant, E" uniqKey="Grant E">E Grant</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Renfrey, S" uniqKey="Renfrey S">S Renfrey</name>
</author>
<author><name sortKey="Watts, A" uniqKey="Watts A">A Watts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garcia Ca As, V" uniqKey="Garcia Ca As V">V García-Cañas</name>
</author>
<author><name sortKey="Lorbetskie, B" uniqKey="Lorbetskie B">B Lorbetskie</name>
</author>
<author><name sortKey="Bertrand, D" uniqKey="Bertrand D">D Bertrand</name>
</author>
<author><name sortKey="Cyr, Td" uniqKey="Cyr T">TD Cyr</name>
</author>
<author><name sortKey="Girard, M" uniqKey="Girard M">M Girard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mbawuike, I" uniqKey="Mbawuike I">I Mbawuike</name>
</author>
<author><name sortKey="Zang, Y" uniqKey="Zang Y">Y Zang</name>
</author>
<author><name sortKey="Couch, Rb" uniqKey="Couch R">RB Couch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lamere, M" uniqKey="Lamere M">M LaMere</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rudra, Js" uniqKey="Rudra J">JS Rudra</name>
</author>
<author><name sortKey="Tripathi, Pk" uniqKey="Tripathi P">PK Tripathi</name>
</author>
<author><name sortKey="Hildeman, Da" uniqKey="Hildeman D">DA Hildeman</name>
</author>
<author><name sortKey="Jung, Jp" uniqKey="Jung J">JP Jung</name>
</author>
<author><name sortKey="Collier, Jh" uniqKey="Collier J">JH Collier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ogun, Sa" uniqKey="Ogun S">SA Ogun</name>
</author>
<author><name sortKey="Dumon Seignovert, L" uniqKey="Dumon Seignovert L">L Dumon-Seignovert</name>
</author>
<author><name sortKey="Marchand, Jb" uniqKey="Marchand J">JB Marchand</name>
</author>
<author><name sortKey="Holder, Aa" uniqKey="Holder A">AA Holder</name>
</author>
<author><name sortKey="Hill, F" uniqKey="Hill F">F Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hofmeyer, T" uniqKey="Hofmeyer T">T Hofmeyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forbes, Ek" uniqKey="Forbes E">EK Forbes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spencer, Aj" uniqKey="Spencer A">AJ Spencer</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, W" uniqKey="Smith W">W Smith</name>
</author>
<author><name sortKey="Andrewes, Ch" uniqKey="Andrewes C">CH Andrewes</name>
</author>
<author><name sortKey="Laidlaw, Pp" uniqKey="Laidlaw P">PP Laidlaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gallagher, Jr" uniqKey="Gallagher J">JR Gallagher</name>
</author>
<author><name sortKey="Torian, U" uniqKey="Torian U">U Torian</name>
</author>
<author><name sortKey="Mccraw, Dm" uniqKey="Mccraw D">DM McCraw</name>
</author>
<author><name sortKey="Harris, Ak" uniqKey="Harris A">AK Harris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ye, Q" uniqKey="Ye Q">Q Ye</name>
</author>
<author><name sortKey="Krug, Rm" uniqKey="Krug R">RM Krug</name>
</author>
<author><name sortKey="Tao, Yj" uniqKey="Tao Y">YJ Tao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naik, Sh" uniqKey="Naik S">SH Naik</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Berthoud, Tk" uniqKey="Berthoud T">TK Berthoud</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thomas, Pg" uniqKey="Thomas P">PG Thomas</name>
</author>
<author><name sortKey="Keating, R" uniqKey="Keating R">R Keating</name>
</author>
<author><name sortKey="Hulse Post, Dj" uniqKey="Hulse Post D">DJ Hulse-Post</name>
</author>
<author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gilbert, Sc" uniqKey="Gilbert S">SC Gilbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nachbagauer, R" uniqKey="Nachbagauer R">R Nachbagauer</name>
</author>
<author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fiore, Ae" uniqKey="Fiore A">AE Fiore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Usonis, V" uniqKey="Usonis V">V Usonis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bodewes, R" uniqKey="Bodewes R">R Bodewes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ulmer, Jb" uniqKey="Ulmer J">JB Ulmer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ulmer, Jb" uniqKey="Ulmer J">JB Ulmer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fu, Tm" uniqKey="Fu T">TM Fu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name>
</author>
<author><name sortKey="Price, Ge" uniqKey="Price G">GE Price</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rangel Moreno, J" uniqKey="Rangel Moreno J">J Rangel-Moreno</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wraith, Dc" uniqKey="Wraith D">DC Wraith</name>
</author>
<author><name sortKey="Vessey, Ae" uniqKey="Vessey A">AE Vessey</name>
</author>
<author><name sortKey="Askonas, Ba" uniqKey="Askonas B">BA Askonas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wraith, Dc" uniqKey="Wraith D">DC Wraith</name>
</author>
<author><name sortKey="Askonas, Ba" uniqKey="Askonas B">BA Askonas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guo, L" uniqKey="Guo L">L Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, B" uniqKey="Huang B">B Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zheng, M" uniqKey="Zheng M">M Zheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hutchings, Cl" uniqKey="Hutchings C">CL Hutchings</name>
</author>
<author><name sortKey="Gilbert, Sc" uniqKey="Gilbert S">SC Gilbert</name>
</author>
<author><name sortKey="Hill, Av" uniqKey="Hill A">AV Hill</name>
</author>
<author><name sortKey="Moore, Ac" uniqKey="Moore A">AC Moore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kreijtz, Jh" uniqKey="Kreijtz J">JH Kreijtz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lambe, T" uniqKey="Lambe T">T Lambe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hillaire, Ml" uniqKey="Hillaire M">ML Hillaire</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
<author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Antrobus, Rd" uniqKey="Antrobus R">RD Antrobus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lambe, T" uniqKey="Lambe T">T Lambe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Su, F" uniqKey="Su F">F Su</name>
</author>
<author><name sortKey="Patela, Gb" uniqKey="Patela G">GB Patela</name>
</author>
<author><name sortKey="Hua, S" uniqKey="Hua S">S Hua</name>
</author>
<author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Babar, Mm" uniqKey="Babar M">MM Babar</name>
</author>
<author><name sortKey="Zaidi, Nu" uniqKey="Zaidi N">NU Zaidi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luo, M" uniqKey="Luo M">M Luo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fodor, E" uniqKey="Fodor E">E Fodor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Brito, C" uniqKey="De Brito C">C de Brito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brinza, L" uniqKey="Brinza L">L Brinza</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Townsend, Ar" uniqKey="Townsend A">AR Townsend</name>
</author>
</analytic>
</biblStruct>
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