Dysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus
Identifieur interne : 000E15 ( Ncbi/Curation ); précédent : 000E14; suivant : 000E16Dysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus
Auteurs : Sun-Woo Yoon [États-Unis, Corée du Sud] ; Sook-San Wong [États-Unis] ; Huachen Zhu [République populaire de Chine] ; Rirong Chen ; Long Li ; Yu Zhang ; Yi Guan [République populaire de Chine] ; Richard J. Webby [États-Unis]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2017.
Abstract
Infection with 2009 pandemic influenza A(H1N1) virus during pregnancy induces more-severe disease as a consequence of elevated viral loads and innate responses combined with a diminished adaptive response. These factors likely contributed to the increased morbidity and mortality observed in pregnant women during the 2009 pandemic.
Url:
DOI: 10.1093/infdis/jix328
PubMed: 28973317
PubMed Central: 5853788
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Huachen Zhu<affiliation><nlm:aff id="AF0003">Joint Influenza Research Centre, Shantou University Medical College, Shantou</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p>Infection with 2009 pandemic influenza A(H1N1) virus during pregnancy induces more-severe disease as a consequence of elevated viral loads and innate responses combined with a diminished adaptive response. These factors likely contributed to the increased morbidity and mortality observed in pregnant women during the 2009 pandemic.</p>
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