Pathogenicity and transmission of a swine influenza A(H6N6) virus
Identifieur interne : 000D67 ( Ncbi/Curation ); précédent : 000D66; suivant : 000D68Pathogenicity and transmission of a swine influenza A(H6N6) virus
Auteurs : Hailiang Sun [États-Unis] ; Bryan S. Kaplan [États-Unis] ; Minhui Guan [États-Unis] ; Guihong Zhang [République populaire de Chine] ; Jianqiang Ye [États-Unis] ; Li-Ping Long [États-Unis] ; Sherry Blackmon [États-Unis] ; Chun-Kai Yang [États-Unis] ; Meng-Jung Chiang [États-Unis] ; Hang Xie [États-Unis] ; Nan Zhao [États-Unis] ; Jim Cooley [États-Unis] ; David F. Smith [États-Unis] ; Ming Liao [République populaire de Chine] ; Carol Cardona [États-Unis] ; Lei Li [États-Unis] ; George Peng Wang [États-Unis] ; Richard Webby [États-Unis] ; Xiu-Feng Wan [États-Unis]Source :
- Emerging Microbes & Infections [ 2222-1751 ] ; 2017.
Abstract
Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets. The internal genes of the influenza A(H1N1)pdm09 virus, which is prevalent in swine worldwide, increases the replication efficiency of H6N6 IAV in the lower respiratory tract of ferrets but not its transmissibility between ferrets. These findings suggest H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its evolution and spread should be closely monitored.
Url:
DOI: 10.1038/emi.2017.3
PubMed: 28400591
PubMed Central: 5457681
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PMC:5457681Le document en format XML
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<author><name sortKey="Chiang, Meng Jung" sort="Chiang, Meng Jung" uniqKey="Chiang M" first="Meng-Jung" last="Chiang">Meng-Jung Chiang</name>
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<author><name sortKey="Smith, David F" sort="Smith, David F" uniqKey="Smith D" first="David F" last="Smith">David F. Smith</name>
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, Atlanta 30322, GA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Liao, Ming" sort="Liao, Ming" uniqKey="Liao M" first="Ming" last="Liao">Ming Liao</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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, St Paul, MN 30322,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Wang, George Peng" sort="Wang, George Peng" uniqKey="Wang G" first="George Peng" last="Wang">George Peng Wang</name>
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<author><name sortKey="Webby, Richard" sort="Webby, Richard" uniqKey="Webby R" first="Richard" last="Webby">Richard Webby</name>
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, Memphis, TN 38105,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Wan, Xiu Feng" sort="Wan, Xiu Feng" uniqKey="Wan X" first="Xiu-Feng" last="Wan">Xiu-Feng Wan</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University</institution>
, Mississippi State, MS 39759,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<series><title level="j">Emerging Microbes & Infections</title>
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<front><div type="abstract" xml:lang="en"><p>Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets. The internal genes of the influenza A(H1N1)pdm09 virus, which is prevalent in swine worldwide, increases the replication efficiency of H6N6 IAV in the lower respiratory tract of ferrets but not its transmissibility between ferrets. These findings suggest H6N6 swine IAV (SIV) currently poses a moderate risk to public health, but its evolution and spread should be closely monitored.</p>
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