Characterization of the M protein and nucleoprotein genes of an avian influenza A virus which are involved in host range restriction in monkeys.
Identifieur interne : 000B90 ( Ncbi/Curation ); précédent : 000B89; suivant : 000B91Characterization of the M protein and nucleoprotein genes of an avian influenza A virus which are involved in host range restriction in monkeys.
Auteurs : B R Murphy [États-Unis] ; A J Buckler-White ; W T London ; M H SnyderSource :
- Vaccine [ 0264-410X ] ; 1989.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Animaux, Gènes viraux, Nucléoprotéines (génétique), Protéines de la matrice virale (génétique), Protéines de liaison à l'ARN, Protéines du core viral, Protéines virales (génétique), Réplication virale, Saimiri, Séquence d'acides aminés, Séquence nucléotidique, Virus de la grippe A (génétique).
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : RNA, Viral.
- chemical , genetics : Nucleoproteins, Viral Matrix Proteins, Viral Proteins.
- genetics : Influenza A virus.
- Amino Acid Sequence, Animals, Base Sequence, Genes, Viral, RNA-Binding Proteins, Saimiri, Viral Core Proteins, Virus Replication.
Abstract
A reassortant virus possessing RNA segment 7, which codes for the M1 and M2 proteins, of the avian influenza A/Mallard/New York/6750/78 (H2N2) virus and the other seven RNA segments of the human influenza A/Udorn/307/72 (H3N2) virus had been shown previously to be markedly restricted in replication in the respiratory tract of squirrel monkeys. In contrast, a reassortant possessing segment 7 of another avian influenza virus, A/Pintail/Alberta/119/79 (H4N6), and the seven other RNA segments from the A/Udorn/72 virus was not restricted. The nucleotide and deduced amino acid sequence of the RNA segment 7 of each virus was determined to identify the structural basis for the attenuation phenotype specified by RNA segment 7 of the A/Mallard/78 virus. Analysis of the deduced amino acid sequences revealed only two amino acid differences in the M1 protein and one difference in the M2 protein, suggesting that the attenuation phenotype of a reassortant virus possessing segment 7 of the A/Mallard/78 virus may be specified by one to three amino acids. Reassortant viruses possessing RNA segment 6, which codes for the nucleoprotein, of either avian influenza virus and the other seven RNA segments of a human influenza virus were also restricted in replication in squirrel monkeys. A comparison of the deduced amino acid sequences of the two avian nucleopeoteins demonstrated only three amino acid differences indicating that these two avian viruses possess NP genes that are highly related. The high degree of relatedness of both the NP and M proteins of these two avian viruses contrasts with their divergent surface antigens.(ABSTRACT TRUNCATED AT 250 WORDS)
DOI: 10.1016/0264-410x(89)90283-1
PubMed: 2609730
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of the M protein and nucleoprotein genes of an avian influenza A virus which are involved in host range restriction in monkeys.</title><author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Buckler White, A J" sort="Buckler White, A J" uniqKey="Buckler White A" first="A J" last="Buckler-White">A J Buckler-White</name></author><author><name sortKey="London, W T" sort="London, W T" uniqKey="London W" first="W T" last="London">W T London</name></author><author><name sortKey="Snyder, M H" sort="Snyder, M H" uniqKey="Snyder M" first="M H" last="Snyder">M H Snyder</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2609730</idno><idno type="pmid">2609730</idno><idno type="doi">10.1016/0264-410x(89)90283-1</idno><idno type="wicri:Area/PubMed/Corpus">000458</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000458</idno><idno type="wicri:Area/PubMed/Curation">000458</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000458</idno><idno type="wicri:Area/PubMed/Checkpoint">000413</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000413</idno><idno type="wicri:Area/Ncbi/Merge">000B90</idno><idno type="wicri:Area/Ncbi/Curation">000B90</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characterization of the M protein and nucleoprotein genes of an avian influenza A virus which are involved in host range restriction in monkeys.</title><author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Buckler White, A J" sort="Buckler White, A J" uniqKey="Buckler White A" first="A J" last="Buckler-White">A J Buckler-White</name></author><author><name sortKey="London, W T" sort="London, W T" uniqKey="London W" first="W T" last="London">W T London</name></author><author><name sortKey="Snyder, M H" sort="Snyder, M H" uniqKey="Snyder M" first="M H" last="Snyder">M H Snyder</name></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Genes, Viral</term><term>Influenza A virus (genetics)</term><term>Nucleoproteins (genetics)</term><term>RNA, Viral (analysis)</term><term>RNA-Binding Proteins</term><term>Saimiri</term><term>Viral Core Proteins</term><term>Viral Matrix Proteins (genetics)</term><term>Viral Proteins (genetics)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Animaux</term><term>Gènes viraux</term><term>Nucléoprotéines (génétique)</term><term>Protéines de la matrice virale (génétique)</term><term>Protéines de liaison à l'ARN</term><term>Protéines du core viral</term><term>Protéines virales (génétique)</term><term>Réplication virale</term><term>Saimiri</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Virus de la grippe A (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nucleoproteins</term><term>Viral Matrix Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Nucléoprotéines</term><term>Protéines de la matrice virale</term><term>Protéines virales</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Genes, Viral</term><term>RNA-Binding Proteins</term><term>Saimiri</term><term>Viral Core Proteins</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Gènes viraux</term><term>Protéines de liaison à l'ARN</term><term>Protéines du core viral</term><term>Réplication virale</term><term>Saimiri</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A reassortant virus possessing RNA segment 7, which codes for the M1 and M2 proteins, of the avian influenza A/Mallard/New York/6750/78 (H2N2) virus and the other seven RNA segments of the human influenza A/Udorn/307/72 (H3N2) virus had been shown previously to be markedly restricted in replication in the respiratory tract of squirrel monkeys. In contrast, a reassortant possessing segment 7 of another avian influenza virus, A/Pintail/Alberta/119/79 (H4N6), and the seven other RNA segments from the A/Udorn/72 virus was not restricted. The nucleotide and deduced amino acid sequence of the RNA segment 7 of each virus was determined to identify the structural basis for the attenuation phenotype specified by RNA segment 7 of the A/Mallard/78 virus. Analysis of the deduced amino acid sequences revealed only two amino acid differences in the M1 protein and one difference in the M2 protein, suggesting that the attenuation phenotype of a reassortant virus possessing segment 7 of the A/Mallard/78 virus may be specified by one to three amino acids. Reassortant viruses possessing RNA segment 6, which codes for the nucleoprotein, of either avian influenza virus and the other seven RNA segments of a human influenza virus were also restricted in replication in squirrel monkeys. A comparison of the deduced amino acid sequences of the two avian nucleopeoteins demonstrated only three amino acid differences indicating that these two avian viruses possess NP genes that are highly related. The high degree of relatedness of both the NP and M proteins of these two avian viruses contrasts with their divergent surface antigens.(ABSTRACT TRUNCATED AT 250 WORDS)</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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