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Structural insights into key sites of vulnerability on HIV-1 Env and Influenza HA

Identifieur interne : 000820 ( Ncbi/Curation ); précédent : 000819; suivant : 000821

Structural insights into key sites of vulnerability on HIV-1 Env and Influenza HA

Auteurs : Jean-Philippe Julien [États-Unis] ; Peter S. Lee [États-Unis] ; Ian A. Wilson [États-Unis]

Source :

Immunological reviews [ 0105-2896 ] ; 2012.

RBID : PMC:3479221

Abstract

Summary

Human immunodeficiency virus-1 (HIV-1) envelope protein (Env) and influenza hemagglutinin (HA) are the surface glycoproteins responsible for viral entry into host cells, the first step in the virus life cycle necessary to initiate infection. These glycoproteins exhibit a high degree of sequence variability and glycosylation, which are used as strategies to escape host immune responses. Nonetheless, antibodies with broadly neutralizing activity against these viruses have been isolated that have managed to overcome these barriers. Here, we review recent advances in the structural characterization of these antibodies with their viral antigens that defines a few sites of vulnerability on these viral spikes. These broadly neutralizing antibodies tend to focus their recognition on the sites of similar function between the two viruses: the receptor binding site and membrane fusion machinery. However, some sites of recognition are unique to the virus neutralized, such as the dense shield of oligomannose carbohydrates on HIV-1 Env. These observations are discussed in the context of structure-based design strategies to aid in vaccine design or development of antivirals.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479221

DOI: 10.1111/imr.12005
PubMed: 23046130
PubMed Central: 3479221

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PMC:3479221

Le document en format XML

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Structural insights into key sites of vulnerability on HIV-1 Env and Influenza HA

Structural insights into key sites of vulnerability on HIV-1 Env and Influenza HA

Source :

Abstract

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Le document en format XML

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Pour générer des pages wiki