Innate immune responses to influenza A H5N1: friend or foe?
Identifieur interne : 000431 ( Ncbi/Curation ); précédent : 000430; suivant : 000432Innate immune responses to influenza A H5N1: friend or foe?
Auteurs : Jsm Peiris [République populaire de Chine] ; Cy Cheung [République populaire de Chine] ; Cyh Leung [République populaire de Chine] ; Jm Nicholls [République populaire de Chine]Source :
- Trends in immunology [ 1471-4906 ] ; 2009.
Abstract
Avian influenza A H5N1 remains unusual in its virulence for humans. While infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia leading to acute respiratory distress syndrome and death but its pathogenesis remains an enigma. Comparisons in the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1) and H5N1 in patients, animal models and in relevant primary human cell cultures remains instructive. While the direct effects of viral replication and differences in the tropism of the virus for cells in the lower respiratory tract clearly contribute to the pathogenesis, we focus here on the possible contribution of the host innate immune response in the pathogenesis of this disease.
Url:
DOI: 10.1016/j.it.2009.09.004
PubMed: 19864182
PubMed Central: 5068224
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000807
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000807
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000A37
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000431
Links to Exploration step
PMC:5068224Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Innate immune responses to influenza A H5N1: friend or foe?</title><author><name sortKey="Peiris, Jsm" sort="Peiris, Jsm" uniqKey="Peiris J" first="Jsm" last="Peiris">Jsm Peiris</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">HKU-Pasteur Research Centre, Hong Kong Special Administrative Region, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>HKU-Pasteur Research Centre, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Cheung, Cy" sort="Cheung, Cy" uniqKey="Cheung C" first="Cy" last="Cheung">Cy Cheung</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Leung, Cyh" sort="Leung, Cyh" uniqKey="Leung C" first="Cyh" last="Leung">Cyh Leung</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Nicholls, Jm" sort="Nicholls, Jm" uniqKey="Nicholls J" first="Jm" last="Nicholls">Jm Nicholls</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Pathology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19864182</idno><idno type="pmc">5068224</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068224</idno><idno type="RBID">PMC:5068224</idno><idno type="doi">10.1016/j.it.2009.09.004</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000807</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000807</idno><idno type="wicri:Area/Pmc/Curation">000807</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000807</idno><idno type="wicri:Area/Pmc/Checkpoint">000A37</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A37</idno><idno type="wicri:Area/Ncbi/Merge">000431</idno><idno type="wicri:Area/Ncbi/Curation">000431</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Innate immune responses to influenza A H5N1: friend or foe?</title><author><name sortKey="Peiris, Jsm" sort="Peiris, Jsm" uniqKey="Peiris J" first="Jsm" last="Peiris">Jsm Peiris</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">HKU-Pasteur Research Centre, Hong Kong Special Administrative Region, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>HKU-Pasteur Research Centre, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Cheung, Cy" sort="Cheung, Cy" uniqKey="Cheung C" first="Cy" last="Cheung">Cy Cheung</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Leung, Cyh" sort="Leung, Cyh" uniqKey="Leung C" first="Cyh" last="Leung">Cyh Leung</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Nicholls, Jm" sort="Nicholls, Jm" uniqKey="Nicholls J" first="Jm" last="Nicholls">Jm Nicholls</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Pathology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author></analytic><series><title level="j">Trends in immunology</title><idno type="ISSN">1471-4906</idno><idno type="eISSN">1471-4981</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Avian influenza A H5N1 remains unusual in its virulence for humans. While infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia leading to acute respiratory distress syndrome and death but its pathogenesis remains an enigma. Comparisons in the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1) and H5N1 in patients, animal models and in relevant primary human cell cultures remains instructive. While the direct effects of viral replication and differences in the tropism of the virus for cells in the lower respiratory tract clearly contribute to the pathogenesis, we focus here on the possible contribution of the host innate immune response in the pathogenesis of this disease.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000431 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000431 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= PMC:5068224
|texte= Innate immune responses to influenza A H5N1: friend or foe?
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:19864182" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |