H2N2V1, Ncbi, Curation, bibRecord, 000129

The influenza virus neuraminidase contributes to secondary bacterial pneumonia

Identifieur interne : 000129 ( Ncbi/Curation ); précédent : 000128; suivant : 000130

The influenza virus neuraminidase contributes to secondary bacterial pneumonia

Auteurs : Ville T. Peltola [États-Unis] ; K. Gopal Murti [États-Unis] ; Jonathan A. Mccullers [États-Unis]

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 2005.

RBID : PMC:2715995

Abstract

Secondary bacterial pneumonia is a common cause of death during influenza epidemics. We hypothesized that virus-specific factors could contribute to differences in annual excess mortality. A set of recombinant viruses with neuraminidases from representative influenza virus strains from the last 50 years was created and characterized. Their specific neuraminidase activities correlated with their ability to support secondary bacterial infections. Recombinant viruses with the 1957 and 1997 neuraminidases had the highest activities, while a virus with the 1968 neuraminidase had the lowest activity. The high activity of the 1957 neuraminidase, when compared to other neuraminidases, more strongly supported bacterial adherence in vitro and secondary pneumococcal pneumonia in a mouse model. These data lend support to our hypothesis that the neuraminidase of influenza viruses contributes to secondary bacterial infections and subsequent excess mortality.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715995

DOI: 10.1086/430954
PubMed: 15962219
PubMed Central: 2715995

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PMC:2715995

Le document en format XML

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<affiliation wicri:level="2"><nlm:aff id="A1">Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p id="P2">Secondary bacterial pneumonia is a common cause of death during influenza epidemics. We hypothesized that virus-specific factors could contribute to differences in annual excess mortality. A set of recombinant viruses with neuraminidases from representative influenza virus strains from the last 50 years was created and characterized. Their specific neuraminidase activities correlated with their ability to support secondary bacterial infections. Recombinant viruses with the 1957 and 1997 neuraminidases had the highest activities, while a virus with the 1968 neuraminidase had the lowest activity. The high activity of the 1957 neuraminidase, when compared to other neuraminidases, more strongly supported bacterial adherence in vitro and secondary pneumococcal pneumonia in a mouse model. These data lend support to our hypothesis that the neuraminidase of influenza viruses contributes to secondary bacterial infections and subsequent excess mortality.</p>
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The influenza virus neuraminidase contributes to secondary bacterial pneumonia

The influenza virus neuraminidase contributes to secondary bacterial pneumonia

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki