Studies with a cold-recombinant A/Victoria/3/75 (H3N2) virus. I. biologic, genetic, and biochemical characterization.
Identifieur interne : 001284 ( Ncbi/Checkpoint ); précédent : 001283; suivant : 001285Studies with a cold-recombinant A/Victoria/3/75 (H3N2) virus. I. biologic, genetic, and biochemical characterization.
Auteurs : P. Reeve ; J W Almond ; V. Felsenreich ; M. Pibermann ; H F MaassabSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 1980.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Antigènes viraux.
- génétique : ARN viral, Virus de la grippe A.
- immunologie : Vaccins antigrippaux, Virus de la grippe A.
- Animaux, Basse température, Embryon de poulet, Mutation, Recombinaison génétique, Sous-type H3N2 du virus de la grippe A, Variation génétique.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Antigens, Viral.
- genetics : Influenza A virus, RNA, Viral.
- immunology : Influenza A virus, Influenza Vaccines.
- Animals, Chick Embryo, Cold Temperature, Genetic Variation, Influenza A Virus, H3N2 Subtype, Mutation, Recombination, Genetic.
Abstract
A cold-recombinant virus CR 22, was derived from an attenuated cold-adapted parent strain. A/Ann Arbor/6/60 (H2N2), and a wild-type parent strain, A/Victoria/3/75 (H3N2). Antigenic analysis showed that CR 22 possesses the hemagglutinin and neruaminidase surface antigens derived from the A/Victoria/3/75 (H3N2) parent. From studies of virus-induced polypeptides using polyacrylamide gel electrophoresis, it was deduced that a polymerase protein, P1, is coded and by an RNA segment derived from the wild-type parent; all other genetic elements are derived from the attenuated parent. The attenuated parent and the recombinant CR 22 both possess temperature-sensitive (ts) lesions, evident by restriction of multiplication in fertile chicken eggs or in Madin-Darby canine kidney cell cultures at greater than or equal to 38 C. Genetic analysis of CR 22 by complementation tests using Hong Kong and Wilson Smith neurotropic ts mutants gave evidence for a ts lesion in the genetic elements coding for complementary RNA.
DOI: 10.1093/infdis/142.6.850
PubMed: 7462696
Affiliations:
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pubmed:7462696Le document en format XML
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<term>Chick Embryo</term>
<term>Cold Temperature</term>
<term>Genetic Variation</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Mutation</term>
<term>RNA, Viral (genetics)</term>
<term>Recombination, Genetic</term>
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<term>Animaux</term>
<term>Antigènes viraux (analyse)</term>
<term>Basse température</term>
<term>Embryon de poulet</term>
<term>Mutation</term>
<term>Recombinaison génétique</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Variation génétique</term>
<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (immunologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Viral</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term>
<term>RNA, Viral</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term>
<term>Virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
<term>Virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term>
<term>Influenza Vaccines</term>
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<term>Cold Temperature</term>
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<term>Influenza A Virus, H3N2 Subtype</term>
<term>Mutation</term>
<term>Recombination, Genetic</term>
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<term>Basse température</term>
<term>Embryon de poulet</term>
<term>Mutation</term>
<term>Recombinaison génétique</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Variation génétique</term>
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<front><div type="abstract" xml:lang="en">A cold-recombinant virus CR 22, was derived from an attenuated cold-adapted parent strain. A/Ann Arbor/6/60 (H2N2), and a wild-type parent strain, A/Victoria/3/75 (H3N2). Antigenic analysis showed that CR 22 possesses the hemagglutinin and neruaminidase surface antigens derived from the A/Victoria/3/75 (H3N2) parent. From studies of virus-induced polypeptides using polyacrylamide gel electrophoresis, it was deduced that a polymerase protein, P1, is coded and by an RNA segment derived from the wild-type parent; all other genetic elements are derived from the attenuated parent. The attenuated parent and the recombinant CR 22 both possess temperature-sensitive (ts) lesions, evident by restriction of multiplication in fertile chicken eggs or in Madin-Darby canine kidney cell cultures at greater than or equal to 38 C. Genetic analysis of CR 22 by complementation tests using Hong Kong and Wilson Smith neurotropic ts mutants gave evidence for a ts lesion in the genetic elements coding for complementary RNA.</div>
</front>
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<tree><noCountry><name sortKey="Almond, J W" sort="Almond, J W" uniqKey="Almond J" first="J W" last="Almond">J W Almond</name>
<name sortKey="Felsenreich, V" sort="Felsenreich, V" uniqKey="Felsenreich V" first="V" last="Felsenreich">V. Felsenreich</name>
<name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H F" last="Maassab">H F Maassab</name>
<name sortKey="Pibermann, M" sort="Pibermann, M" uniqKey="Pibermann M" first="M" last="Pibermann">M. Pibermann</name>
<name sortKey="Reeve, P" sort="Reeve, P" uniqKey="Reeve P" first="P" last="Reeve">P. Reeve</name>
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