Characterization of cells infiltrating the lungs of x-irradiated and nude mice after influenza virus infection.
Identifieur interne : 001234 ( Ncbi/Checkpoint ); précédent : 001233; suivant : 001235Characterization of cells infiltrating the lungs of x-irradiated and nude mice after influenza virus infection.
Auteurs : E. Shimomura ; F. Suzuki ; N. IshidaSource :
- Microbiology and immunology [ 0385-5600 ] ; 1982.
Descripteurs français
- KwdFr :
- Animaux, Cellules tueuses naturelles (physiologie), Cinétique, Infections à Orthomyxoviridae (anatomopathologie), Lymphocytes (cytologie), Lymphocytes (physiologie), Lymphocytes T (physiologie), Pneumopathie virale (anatomopathologie), Poumon (anatomopathologie), Souris, Souris de lignée BALB C, Souris de lignée C3H, Souris nude.
- MESH :
- anatomopathologie : Infections à Orthomyxoviridae, Pneumopathie virale, Poumon.
- cytologie : Lymphocytes.
- physiologie : Cellules tueuses naturelles, Lymphocytes, Lymphocytes T.
- Animaux, Cinétique, Souris, Souris de lignée BALB C, Souris de lignée C3H, Souris nude.
English descriptors
- KwdEn :
- MESH :
- cytology : Lymphocytes.
- pathology : Lung, Orthomyxoviridae Infections, Pneumonia, Viral.
- physiology : Killer Cells, Natural, Lymphocytes, T-Lymphocytes.
- Animals, Kinetics, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Nude.
Abstract
After X-irradiated and nonirradiated mice (C3H/He) as well as athymic nude mice and haired littermates (BALB/c) were infected with influenza A virus (Kumamoto strain, H2N2), they were examined for survival period, the development of consolidation in the lungs and the characteristics of the cells infiltrating the lung tissues. In two different T-cell deficient groups, there was a definite delay in the development of consolidation compared with their respective controls and this was reflected in prolonged survival periods: 5 days longer for irradiated mice and 6 days longer for nude mice. In both T-cell deficient and normal groups, about 70% of the cells obtained from consolidated lung tissues after virus infection were found to be small lymphoid cells and there were no morphological differences between the T-cell deficient and normal groups. None of these small lymphoid cells from the peripheral blood or the spleen of T-cell deficient mice responded to concanavalin A. In the lungs of both X-irradiated mice and nude mice, however, a definite increase in cells having natural killer activity was found at the late stages of the influenza infection, suggesting their participation in the development of consolidation.
DOI: 10.1111/j.1348-0421.1982.tb00162.x
PubMed: 6979669
Affiliations:
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Ishida</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1982">1982</date><idno type="RBID">pubmed:6979669</idno><idno type="pmid">6979669</idno><idno type="doi">10.1111/j.1348-0421.1982.tb00162.x</idno><idno type="wicri:Area/PubMed/Corpus">000567</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000567</idno><idno type="wicri:Area/PubMed/Curation">000567</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000567</idno><idno type="wicri:Area/PubMed/Checkpoint">000490</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000490</idno><idno type="wicri:Area/Ncbi/Merge">001234</idno><idno type="wicri:Area/Ncbi/Curation">001234</idno><idno type="wicri:Area/Ncbi/Checkpoint">001234</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characterization of cells infiltrating the lungs of x-irradiated and nude mice after influenza virus infection.</title><author><name sortKey="Shimomura, E" sort="Shimomura, E" uniqKey="Shimomura E" first="E" last="Shimomura">E. Shimomura</name></author><author><name sortKey="Suzuki, F" sort="Suzuki, F" uniqKey="Suzuki F" first="F" last="Suzuki">F. Suzuki</name></author><author><name sortKey="Ishida, N" sort="Ishida, N" uniqKey="Ishida N" first="N" last="Ishida">N. Ishida</name></author></analytic><series><title level="j">Microbiology and immunology</title><idno type="ISSN">0385-5600</idno><imprint><date when="1982" type="published">1982</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Killer Cells, Natural (physiology)</term><term>Kinetics</term><term>Lung (pathology)</term><term>Lymphocytes (cytology)</term><term>Lymphocytes (physiology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C3H</term><term>Mice, Nude</term><term>Orthomyxoviridae Infections (pathology)</term><term>Pneumonia, Viral (pathology)</term><term>T-Lymphocytes (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules tueuses naturelles (physiologie)</term><term>Cinétique</term><term>Infections à Orthomyxoviridae (anatomopathologie)</term><term>Lymphocytes (cytologie)</term><term>Lymphocytes (physiologie)</term><term>Lymphocytes T (physiologie)</term><term>Pneumopathie virale (anatomopathologie)</term><term>Poumon (anatomopathologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C3H</term><term>Souris nude</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Pneumopathie virale</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Orthomyxoviridae Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules tueuses naturelles</term><term>Lymphocytes</term><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Killer Cells, Natural</term><term>Lymphocytes</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Kinetics</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C3H</term><term>Mice, Nude</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cinétique</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C3H</term><term>Souris nude</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">After X-irradiated and nonirradiated mice (C3H/He) as well as athymic nude mice and haired littermates (BALB/c) were infected with influenza A virus (Kumamoto strain, H2N2), they were examined for survival period, the development of consolidation in the lungs and the characteristics of the cells infiltrating the lung tissues. In two different T-cell deficient groups, there was a definite delay in the development of consolidation compared with their respective controls and this was reflected in prolonged survival periods: 5 days longer for irradiated mice and 6 days longer for nude mice. In both T-cell deficient and normal groups, about 70% of the cells obtained from consolidated lung tissues after virus infection were found to be small lymphoid cells and there were no morphological differences between the T-cell deficient and normal groups. None of these small lymphoid cells from the peripheral blood or the spleen of T-cell deficient mice responded to concanavalin A. In the lungs of both X-irradiated mice and nude mice, however, a definite increase in cells having natural killer activity was found at the late stages of the influenza infection, suggesting their participation in the development of consolidation.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ishida, N" sort="Ishida, N" uniqKey="Ishida N" first="N" last="Ishida">N. Ishida</name><name sortKey="Shimomura, E" sort="Shimomura, E" uniqKey="Shimomura E" first="E" last="Shimomura">E. Shimomura</name><name sortKey="Suzuki, F" sort="Suzuki, F" uniqKey="Suzuki F" first="F" last="Suzuki">F. Suzuki</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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