Immune interferon produced to high levels by antigenic stimulation of human lymphocytes with influenza virus
Identifieur interne : 001170 ( Ncbi/Checkpoint ); précédent : 001169; suivant : 001171Immune interferon produced to high levels by antigenic stimulation of human lymphocytes with influenza virus
Auteurs :Source :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 1981.
Abstract
Influenza virus stimulation of human lymphocytes induced high levels of immune interferon in lymphocyte cultures. The lymphocytes of normal adults produced approximately 1,000 U/10(6) cells, which was in large part gamma interferon. The lymphocytes of individuals recently vaccinated yielded very high levels (10-50,000 U/10(6) cells) of interferon. The interferon was pH 2 labile, and was not neutralized by antisera to alpha or beta interferon. It did not bind to a monoclonal antibody to alpha interferon, and after partial purification it had characteristics identical to human gamma interferon induced by phytohemagglutinin. The highest yields were produced by treatment of stimulator cells with live virus. Stimulation by whole inactivated virus resulted in lower levels of interferon, and purified hemagglutinin did not induce interferon. The antigen responsible for stimulating the lymphocyte response and interferon induction is a cross- reactive determinant present on all human and non-human influenza viruses tested.
Url:
PubMed: 6170714
PubMed Central: 2186530
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A07
- to stream Pmc, to step Curation: 000A07
- to stream Pmc, to step Checkpoint: 000D72
- to stream Ncbi, to step Merge: 001170
- to stream Ncbi, to step Curation: 001170
Links to Exploration step
PMC:2186530Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immune interferon produced to high levels by antigenic stimulation of human lymphocytes with influenza virus</title>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">6170714</idno>
<idno type="pmc">2186530</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186530</idno>
<idno type="RBID">PMC:2186530</idno>
<date when="1981">1981</date>
<idno type="wicri:Area/Pmc/Corpus">000A07</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A07</idno>
<idno type="wicri:Area/Pmc/Curation">000A07</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A07</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000D72</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D72</idno>
<idno type="wicri:Area/Ncbi/Merge">001170</idno>
<idno type="wicri:Area/Ncbi/Curation">001170</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001170</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immune interferon produced to high levels by antigenic stimulation of human lymphocytes with influenza virus</title>
</analytic>
<series><title level="j">The Journal of Experimental Medicine</title>
<idno type="ISSN">0022-1007</idno>
<idno type="eISSN">1540-9538</idno>
<imprint><date when="1981">1981</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Influenza virus stimulation of human lymphocytes induced high levels of immune interferon in lymphocyte cultures. The lymphocytes of normal adults produced approximately 1,000 U/10(6) cells, which was in large part gamma interferon. The lymphocytes of individuals recently vaccinated yielded very high levels (10-50,000 U/10(6) cells) of interferon. The interferon was pH 2 labile, and was not neutralized by antisera to alpha or beta interferon. It did not bind to a monoclonal antibody to alpha interferon, and after partial purification it had characteristics identical to human gamma interferon induced by phytohemagglutinin. The highest yields were produced by treatment of stimulator cells with live virus. Stimulation by whole inactivated virus resulted in lower levels of interferon, and purified hemagglutinin did not induce interferon. The antigen responsible for stimulating the lymphocyte response and interferon induction is a cross- reactive determinant present on all human and non-human influenza viruses tested.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree></tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001170 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 001170 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= PMC:2186530 |texte= Immune interferon produced to high levels by antigenic stimulation of human lymphocytes with influenza virus }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:6170714" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
This area was generated with Dilib version V0.6.33. |